Hallmarks of Severe COVID-19 Pathogenesis: A Pas de Deux Between Viral and Host Factors

Two years into Coronavirus Disease 2019 (COVID-19) pandemic, a comprehensive characterization of the pathogenesis of severe and critical forms of COVID-19 is still missing. While a deep dysregulation of both the magnitude and functionality of innate and adaptive immune responses have been described...

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Veröffentlicht in:Frontiers in immunology Jg. 13; S. 912336
Hauptverfasser: Rovito, Roberta, Augello, Matteo, Ben-Haim, Assaf, Bono, Valeria, d’Arminio Monforte, Antonella, Marchetti, Giulia
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Switzerland Frontiers Media S.A 10.06.2022
Schlagworte:
biomarker
COVID-19
Humans
immune dysregulation
immunity
Immunity, Humoral
Immunology
Pandemics
SARS-CoV-2
severity
COVID-19
microbiota
severity
SARS-CoV-2
gut-lung axis
immunity
biomarker
immune dysregulation
ISSN:1664-3224, 1664-3224
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Zusammenfassung:Two years into Coronavirus Disease 2019 (COVID-19) pandemic, a comprehensive characterization of the pathogenesis of severe and critical forms of COVID-19 is still missing. While a deep dysregulation of both the magnitude and functionality of innate and adaptive immune responses have been described in severe COVID-19, the mechanisms underlying such dysregulations are still a matter of scientific debate, in turn hampering the identification of new therapies and of subgroups of patients that would most benefit from individual clinical interventions. Here we review the current understanding of viral and host factors that contribute to immune dysregulation associated with COVID-19 severity in the attempt to unfold and broaden the comprehension of COVID-19 pathogenesis and to define correlates of protection to further inform strategies of targeted therapeutic interventions.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
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Edited by: Federica Pulvirenti, Accademic Hospital Policlinico Umberto, Italy
This article was submitted to Primary Immunodeficiencies, a section of the journal Frontiers in Immunology
Reviewed by: Sudipta Kumar Sinha, Indian Institute of Technology Ropar, India; Marcos Lopez-Hoyos, Marqués de Valdecilla Health Research Institute (IDIVAL), Spain
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2022.912336