No bidirectional relationship between depression and periodontitis: A genetic correlation and Mendelian randomization study

Observational and research suggested a bidirectional relationship between depression and periodontitis. We estimated the genetic correlation and examined directionality of causation. The study used summary statistics from published genome wide association studies, with sample sizes ranging from 45,5...

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Bibliographic Details
Published in:	Frontiers in immunology Vol. 13; p. 918404
Main Authors:	Nolde, Michael, Holtfreter, Birte, Kocher, Thomas, Alayash, Zoheir, Reckelkamm, Stefan Lars, Ehmke, Benjamin, Baurecht, Hansjörg, Baumeister, Sebastian-Edgar
Format:	Journal Article
Language:	English
Published:	Switzerland Frontiers Media S.A 22.07.2022
Subjects:	depression Depression - genetics genetic correlation genetic correlation analysis Genome-Wide Association Study Humans Immunology Linkage Disequilibrium mendelian randomization analysis Mendelian Randomization Analysis - methods periodontitis Periodontitis - genetics genetic correlation analysis depression genetic correlation mendelian randomization analysis periodontitis
ISSN:	1664-3224, 1664-3224
Online Access:	Get full text
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