No bidirectional relationship between depression and periodontitis: A genetic correlation and Mendelian randomization study

Observational and research suggested a bidirectional relationship between depression and periodontitis. We estimated the genetic correlation and examined directionality of causation. The study used summary statistics from published genome wide association studies, with sample sizes ranging from 45,5...

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Published in:Frontiers in immunology Vol. 13; p. 918404
Main Authors: Nolde, Michael, Holtfreter, Birte, Kocher, Thomas, Alayash, Zoheir, Reckelkamm, Stefan Lars, Ehmke, Benjamin, Baurecht, Hansjörg, Baumeister, Sebastian-Edgar
Format: Journal Article
Language:English
Published: Switzerland Frontiers Media S.A 22.07.2022
Subjects:
depression
Depression - genetics
genetic correlation
genetic correlation analysis
Genome-Wide Association Study
Humans
Immunology
Linkage Disequilibrium
mendelian randomization analysis
Mendelian Randomization Analysis - methods
periodontitis
Periodontitis - genetics
genetic correlation analysis
depression
genetic correlation
mendelian randomization analysis
periodontitis
ISSN:1664-3224, 1664-3224
Online Access:Get full text
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Summary:Observational and research suggested a bidirectional relationship between depression and periodontitis. We estimated the genetic correlation and examined directionality of causation. The study used summary statistics from published genome wide association studies, with sample sizes ranging from 45,563 to 797,563 individuals of European ancestry. We performed linkage disequilibrium score regression (LDSC) to estimate global correlation and used Heritability Estimation from Summary Statistics (ρ-HESS) to further examine local genetic correlation. Latent Heritable Confounder Mendelian randomization (LHC-MR), Causal Analysis using Summary Effect estimates (CAUSE), and conventional MR approaches assessed bidirectional causation. LDSC observed only weak genetic correlation (r = 0.06, P-Value = 0.619) between depression and periodontitis. Analysis of local genetic correlation using ρ-HESS did not reveal loci of significant local genetic covariance. LHC-MR, CAUSE and conventional MR models provided no support for bidirectional causation between depression and periodontitis, with odds ratios ranging from 1.00 to 1.06 in either direction. Results do not support shared heritability or a causal connection between depression and periodontitis.
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This article was submitted to Inflammation, a section of the journal Frontiers in Immunology
Reviewed by: Mia Rakic, Complutense University of Madrid, Spain; Chunyu Li, West China Hospital, Sichuan University, China
Edited by: Pedro Paulo Chaves Souza, Universidade Federal de Goiás, Brazil
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2022.918404