No bidirectional relationship between depression and periodontitis: A genetic correlation and Mendelian randomization study
Observational and research suggested a bidirectional relationship between depression and periodontitis. We estimated the genetic correlation and examined directionality of causation. The study used summary statistics from published genome wide association studies, with sample sizes ranging from 45,5...
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| Published in: | Frontiers in immunology Vol. 13; p. 918404 |
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| Main Authors: | , , , , , , , |
| Format: | Journal Article |
| Language: | English |
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Frontiers Media S.A
22.07.2022
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| ISSN: | 1664-3224, 1664-3224 |
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| Abstract | Observational and
research suggested a bidirectional relationship between depression and periodontitis. We estimated the genetic correlation and examined directionality of causation.
The study used summary statistics from published genome wide association studies, with sample sizes ranging from 45,563 to 797,563 individuals of European ancestry. We performed linkage disequilibrium score regression (LDSC) to estimate global correlation and used Heritability Estimation from Summary Statistics (ρ-HESS) to further examine local genetic correlation. Latent Heritable Confounder Mendelian randomization (LHC-MR), Causal Analysis using Summary Effect estimates (CAUSE), and conventional MR approaches assessed bidirectional causation.
LDSC observed only weak genetic correlation (r
= 0.06, P-Value = 0.619) between depression and periodontitis. Analysis of local genetic correlation using ρ-HESS did not reveal loci of significant local genetic covariance. LHC-MR, CAUSE and conventional MR models provided no support for bidirectional causation between depression and periodontitis, with odds ratios ranging from 1.00 to 1.06 in either direction.
Results do not support shared heritability or a causal connection between depression and periodontitis. |
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| AbstractList | Observational and in-vivo research suggested a bidirectional relationship between depression and periodontitis. We estimated the genetic correlation and examined directionality of causation.BackgroundObservational and in-vivo research suggested a bidirectional relationship between depression and periodontitis. We estimated the genetic correlation and examined directionality of causation.The study used summary statistics from published genome wide association studies, with sample sizes ranging from 45,563 to 797,563 individuals of European ancestry. We performed linkage disequilibrium score regression (LDSC) to estimate global correlation and used Heritability Estimation from Summary Statistics (ρ-HESS) to further examine local genetic correlation. Latent Heritable Confounder Mendelian randomization (LHC-MR), Causal Analysis using Summary Effect estimates (CAUSE), and conventional MR approaches assessed bidirectional causation.MethodsThe study used summary statistics from published genome wide association studies, with sample sizes ranging from 45,563 to 797,563 individuals of European ancestry. We performed linkage disequilibrium score regression (LDSC) to estimate global correlation and used Heritability Estimation from Summary Statistics (ρ-HESS) to further examine local genetic correlation. Latent Heritable Confounder Mendelian randomization (LHC-MR), Causal Analysis using Summary Effect estimates (CAUSE), and conventional MR approaches assessed bidirectional causation.LDSC observed only weak genetic correlation (rg = 0.06, P-Value = 0.619) between depression and periodontitis. Analysis of local genetic correlation using ρ-HESS did not reveal loci of significant local genetic covariance. LHC-MR, CAUSE and conventional MR models provided no support for bidirectional causation between depression and periodontitis, with odds ratios ranging from 1.00 to 1.06 in either direction.ResultsLDSC observed only weak genetic correlation (rg = 0.06, P-Value = 0.619) between depression and periodontitis. Analysis of local genetic correlation using ρ-HESS did not reveal loci of significant local genetic covariance. LHC-MR, CAUSE and conventional MR models provided no support for bidirectional causation between depression and periodontitis, with odds ratios ranging from 1.00 to 1.06 in either direction.Results do not support shared heritability or a causal connection between depression and periodontitis.ConclusionsResults do not support shared heritability or a causal connection between depression and periodontitis. BackgroundObservational and in-vivo research suggested a bidirectional relationship between depression and periodontitis. We estimated the genetic correlation and examined directionality of causation.MethodsThe study used summary statistics from published genome wide association studies, with sample sizes ranging from 45,563 to 797,563 individuals of European ancestry. We performed linkage disequilibrium score regression (LDSC) to estimate global correlation and used Heritability Estimation from Summary Statistics (ρ-HESS) to further examine local genetic correlation. Latent Heritable Confounder Mendelian randomization (LHC-MR), Causal Analysis using Summary Effect estimates (CAUSE), and conventional MR approaches assessed bidirectional causation.ResultsLDSC observed only weak genetic correlation (rg = 0.06, P-Value = 0.619) between depression and periodontitis. Analysis of local genetic correlation using ρ-HESS did not reveal loci of significant local genetic covariance. LHC-MR, CAUSE and conventional MR models provided no support for bidirectional causation between depression and periodontitis, with odds ratios ranging from 1.00 to 1.06 in either direction.ConclusionsResults do not support shared heritability or a causal connection between depression and periodontitis. Observational and research suggested a bidirectional relationship between depression and periodontitis. We estimated the genetic correlation and examined directionality of causation. The study used summary statistics from published genome wide association studies, with sample sizes ranging from 45,563 to 797,563 individuals of European ancestry. We performed linkage disequilibrium score regression (LDSC) to estimate global correlation and used Heritability Estimation from Summary Statistics (ρ-HESS) to further examine local genetic correlation. Latent Heritable Confounder Mendelian randomization (LHC-MR), Causal Analysis using Summary Effect estimates (CAUSE), and conventional MR approaches assessed bidirectional causation. LDSC observed only weak genetic correlation (r = 0.06, P-Value = 0.619) between depression and periodontitis. Analysis of local genetic correlation using ρ-HESS did not reveal loci of significant local genetic covariance. LHC-MR, CAUSE and conventional MR models provided no support for bidirectional causation between depression and periodontitis, with odds ratios ranging from 1.00 to 1.06 in either direction. Results do not support shared heritability or a causal connection between depression and periodontitis. |
| Author | Alayash, Zoheir Ehmke, Benjamin Baurecht, Hansjörg Kocher, Thomas Baumeister, Sebastian-Edgar Reckelkamm, Stefan Lars Nolde, Michael Holtfreter, Birte |
| AuthorAffiliation | 3 Clinic for Periodontology and Conservative Dentistry, University of Münster , Münster , Germany 1 Institute of Health Services Research in Dentistry, University of Münster , Münster , Germany 4 Department of Epidemiology and Preventive Medicine, University of Regensburg , Regensburg , Germany 2 Department of Restorative Dentistry, Periodontology, Endodontology, and Preventive and Pediatric Dentistry, University Medicine Greifswald , Greifswald , Germany |
| AuthorAffiliation_xml | – name: 2 Department of Restorative Dentistry, Periodontology, Endodontology, and Preventive and Pediatric Dentistry, University Medicine Greifswald , Greifswald , Germany – name: 1 Institute of Health Services Research in Dentistry, University of Münster , Münster , Germany – name: 4 Department of Epidemiology and Preventive Medicine, University of Regensburg , Regensburg , Germany – name: 3 Clinic for Periodontology and Conservative Dentistry, University of Münster , Münster , Germany |
| Author_xml | – sequence: 1 givenname: Michael surname: Nolde fullname: Nolde, Michael – sequence: 2 givenname: Birte surname: Holtfreter fullname: Holtfreter, Birte – sequence: 3 givenname: Thomas surname: Kocher fullname: Kocher, Thomas – sequence: 4 givenname: Zoheir surname: Alayash fullname: Alayash, Zoheir – sequence: 5 givenname: Stefan Lars surname: Reckelkamm fullname: Reckelkamm, Stefan Lars – sequence: 6 givenname: Benjamin surname: Ehmke fullname: Ehmke, Benjamin – sequence: 7 givenname: Hansjörg surname: Baurecht fullname: Baurecht, Hansjörg – sequence: 8 givenname: Sebastian-Edgar surname: Baumeister fullname: Baumeister, Sebastian-Edgar |
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| Copyright | Copyright © 2022 Nolde, Holtfreter, Kocher, Alayash, Reckelkamm, Ehmke, Baurecht and Baumeister. Copyright © 2022 Nolde, Holtfreter, Kocher, Alayash, Reckelkamm, Ehmke, Baurecht and Baumeister 2022 Nolde, Holtfreter, Kocher, Alayash, Reckelkamm, Ehmke, Baurecht and Baumeister |
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| Keywords | genetic correlation analysis depression genetic correlation mendelian randomization analysis periodontitis |
| Language | English |
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| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 This article was submitted to Inflammation, a section of the journal Frontiers in Immunology Reviewed by: Mia Rakic, Complutense University of Madrid, Spain; Chunyu Li, West China Hospital, Sichuan University, China Edited by: Pedro Paulo Chaves Souza, Universidade Federal de Goiás, Brazil |
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research suggested a bidirectional relationship between depression and periodontitis. We estimated the genetic correlation and examined... Observational and in-vivo research suggested a bidirectional relationship between depression and periodontitis. We estimated the genetic correlation and... BackgroundObservational and in-vivo research suggested a bidirectional relationship between depression and periodontitis. We estimated the genetic correlation... |
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| SubjectTerms | depression Depression - genetics genetic correlation genetic correlation analysis Genome-Wide Association Study Humans Immunology Linkage Disequilibrium mendelian randomization analysis Mendelian Randomization Analysis - methods periodontitis Periodontitis - genetics |
| Title | No bidirectional relationship between depression and periodontitis: A genetic correlation and Mendelian randomization study |
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