Glycosaminoglycans and syndecan-4 are involved in SDF-1/CXCL12-mediated invasion of human epitheloid carcinoma HeLa cells

In addition to their physiologic effects in inflammation and angiogenesis, chemokines are involved in cancer pathology. The CXC-chemokine stromal cell-derived factor-1 (SDF-1)/CXCL12 mediates its biological activities through activation of G protein-coupled receptor CXCR4 and binds to glycosaminogly...

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Bibliographic Details
Published in:	Biochimica et biophysica acta Vol. 1790; no. 12; pp. 1643 - 1650
Main Authors:	Brule, Severine, Friand, Véronique, Sutton, Angela, Baleux, Françoise, Gattegno, Liliane, Charnaux, Nathalie
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01.12.2009 Elsevier
Subjects:	Anthracenes - pharmacology Biochemistry, Molecular Biology Carcinoma in Situ - metabolism Carcinoma in Situ - pathology Cell Movement - drug effects Chemokine Chemokine CXCL12 - antagonists & inhibitors Chemokine CXCL12 - pharmacology Chemokine CXCL12 - physiology Dose-Response Relationship, Drug Enzyme Inhibitors - pharmacology Female Glycosaminoglycan Glycosaminoglycans - physiology HeLa Cells Heterocyclic Compounds - pharmacology Humans Invasion Life Sciences Matrix Metalloproteinase 9 - metabolism Matrix Metalloproteinase 9 - physiology Neoplasm Invasiveness Proteoglycan SDF-1/CXCL12 Signal Transduction - drug effects Syndecan Syndecan-4 - physiology Uterine Cervical Neoplasms - metabolism Uterine Cervical Neoplasms - pathology Chemokine Proteoglycan Glycosaminoglycan SDF-1/CXCL12 Invasion Syndecan
ISSN:	0304-4165, 0006-3002, 0167-4889, 1872-8006
Online Access:	Get full text
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