Glycosaminoglycans and syndecan-4 are involved in SDF-1/CXCL12-mediated invasion of human epitheloid carcinoma HeLa cells

In addition to their physiologic effects in inflammation and angiogenesis, chemokines are involved in cancer pathology. The CXC-chemokine stromal cell-derived factor-1 (SDF-1)/CXCL12 mediates its biological activities through activation of G protein-coupled receptor CXCR4 and binds to glycosaminogly...

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Vydáno v:	Biochimica et biophysica acta Ročník 1790; číslo 12; s. 1643 - 1650
Hlavní autoři:	Brule, Severine, Friand, Véronique, Sutton, Angela, Baleux, Françoise, Gattegno, Liliane, Charnaux, Nathalie
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Netherlands Elsevier B.V 01.12.2009 Elsevier
Témata:	Anthracenes - pharmacology Biochemistry, Molecular Biology Carcinoma in Situ - metabolism Carcinoma in Situ - pathology Cell Movement - drug effects Chemokine Chemokine CXCL12 - antagonists & inhibitors Chemokine CXCL12 - pharmacology Chemokine CXCL12 - physiology Dose-Response Relationship, Drug Enzyme Inhibitors - pharmacology Female Glycosaminoglycan Glycosaminoglycans - physiology HeLa Cells Heterocyclic Compounds - pharmacology Humans Invasion Life Sciences Matrix Metalloproteinase 9 - metabolism Matrix Metalloproteinase 9 - physiology Neoplasm Invasiveness Proteoglycan SDF-1/CXCL12 Signal Transduction - drug effects Syndecan Syndecan-4 - physiology Uterine Cervical Neoplasms - metabolism Uterine Cervical Neoplasms - pathology Chemokine Proteoglycan Glycosaminoglycan SDF-1/CXCL12 Invasion Syndecan
ISSN:	0304-4165, 0006-3002, 0167-4889, 1872-8006
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