Alzheimer's disease: insights into pathology, molecular mechanisms, and therapy

Alzheimer's disease (AD), the leading cause of dementia, is characterized by the accumulation of amyloid plaques and neurofibrillary tangles in the brain. This condition casts a significant shadow on global health due to its complex and multifactorial nature. In addition to genetic predispositi...

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Vydáno v:Protein & cell Ročník 16; číslo 2; s. 83 - 120
Hlavní autoři: Zheng, Qiuyang, Wang, Xin
Médium: Journal Article
Jazyk:angličtina
Vydáno: Germany Higher Education Press 01.02.2025
Springer Nature B.V
Oxford University Press
Témata:
Alzheimer Disease - genetics
Alzheimer Disease - metabolism
Alzheimer Disease - pathology
Alzheimer Disease - therapy
Alzheimer's disease
Amyloid
Animals
Biomarkers
Cognitive ability
Dementia
Dementia disorders
Disease prevention
Genomes
Health risk assessment
Humans
Molecular modelling
Neurodegeneration
Neurodegenerative diseases
Neurofibrillary tangles
Pathology
Pathophysiology
Plaque, Amyloid - metabolism
Plaque, Amyloid - pathology
prevention
Public health
Review
Risk assessment
Risk Factors
Senile plaques
risk factors
Alzheimer’s disease
biomarkers
prevention
pathophysiology
ISSN:1674-800X, 1674-8018, 1674-8018
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Popis
Shrnutí:Alzheimer's disease (AD), the leading cause of dementia, is characterized by the accumulation of amyloid plaques and neurofibrillary tangles in the brain. This condition casts a significant shadow on global health due to its complex and multifactorial nature. In addition to genetic predispositions, the development of AD is influenced by a myriad of risk factors, including aging, systemic inflammation, chronic health conditions, lifestyle, and environmental exposures. Recent advancements in understanding the complex pathophysiology of AD are paving the way for enhanced diagnostic techniques, improved risk assessment, and potentially effective prevention strategies. These discoveries are crucial in the quest to unravel the complexities of AD, offering a beacon of hope for improved management and treatment options for the millions affected by this debilitating disease.
Bibliografie:Document accepted on :2024-05-06
risk factors
Document received on :2024-03-04
biomarkers
pathophysiology
Alzheimer's disease
prevention
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SourceType-Scholarly Journals-1
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ISSN:1674-800X
1674-8018
1674-8018
DOI:10.1093/procel/pwae026