Cognitive Impairment in Non-critical, Mild-to-Moderate COVID-19 Survivors

Previous studies of post-acute COVID-19 syndrome have focused on critical cases with severe disease. However, most cases are mild to moderate in disease severity. We aimed to examine cognitive outcomes in cases of non-critical, mild-to-moderate COVID-19. Design, Setting, and Participants: In this cr...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Frontiers in psychology Ročník 13; s. 770459
Hlavní autoři: Henneghan, Ashley M., Lewis, Kimberly A., Gill, Eliana, Kesler, Shelli R.
Médium: Journal Article
Jazyk:angličtina
Vydáno: Switzerland Frontiers Media S.A 17.02.2022
Témata:
anxiety
cognition
COVID-19
executive function
Psychology
psychosocial
COVID-19
anxiety
psychosocial
cognition
executive function
ISSN:1664-1078, 1664-1078
On-line přístup:Získat plný text
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
Popis
Shrnutí:Previous studies of post-acute COVID-19 syndrome have focused on critical cases with severe disease. However, most cases are mild to moderate in disease severity. We aimed to examine cognitive outcomes in cases of non-critical, mild-to-moderate COVID-19. Design, Setting, and Participants: In this cross-sectional study, we enrolled 72 adults aged 22 to 65 years in Central Texas who had non-critical, mild-to-moderate COVID-19 infection between 13 January 2021 and 20 April 2021. We remotely administered cognitive-behavioral testing to determine the frequency of cognitive impairment and examine demographic, clinical, and psychosocial contributors to impairment. The frequency of objective cognitive impairment was 40%. The largest number of participants (24%) showed impairment on a measure of executive functioning. Attention and processing speed was more impaired in males (  = 1.5, 95%CI = 0.23-2.9). Males endorsed lower adherence to social distancing guidelines (  = 590,  = 0.01), which was in turn associated with cognitive impairment across participants (  = -0.30,  = 0.01). Younger age was correlated with impairment (  = -0.26,  = 0.03) but was also associated with racial/ethnic minority status (  = -0.31,  = 0.01) and increased psychological symptoms (  < 0.04). Greater number of COVID-19 symptoms was correlated with lower subjective cognitive function (  = -0.38,  = 0.001) as well as psychosocial function (  > 0.24,  < 0.05). Moderate COVID-19 severity was associated with attention/processing speed impairment (  = 0.27,  = 0.03), increased pain (  = 0.31,  = 0.01), and higher number of COVID-19 symptoms (  = 0.32,  = 0.01). Mild or moderate COVID-19 infection may be associated with cognitive impairments, especially in the domain of executive functioning. A subgroup of younger individuals may be more vulnerable to cognitive and psychosocial effects of COVID-19. Question: How frequent is cognitive impairment among non-critical, mild-to-moderate COVID-19 survivors? In this cross-sectional study of 72 adults, 40% demonstrated cognitive impairment, particularly in executive function. Neurologic sequelae, such as cognitive impairment, may be common following COVID-19 infection.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Edited by: Valerio Santangelo, University of Perugia, Italy
This article was submitted to Cognition, a section of the journal Frontiers in Psychology
Reviewed by: Roberta Ferrucci, University of Milan, Italy; Leila Montaser-Kouhsari, Stanford University, United States
ISSN:1664-1078
1664-1078
DOI:10.3389/fpsyg.2022.770459