PECAM-1 and gelatinase B coexist in vascular cuffs of multiple sclerosis lesions

In multiple sclerosis (MS), the matrix metalloprotease (MMP) gelatinase B/MMP‐9 and platelet endothelial cell adhesion molecule (PECAM)‐1 have both been implicated in trans‐endothelial infiltration of leucocytes into the brain, but their functional connection has not yet been investigated. We invest...

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Bibliographic Details
Published in:	Neuropathology and applied neurobiology Vol. 32; no. 1; pp. 15 - 22
Main Authors:	Nelissen, I., Gveric, D., Van Noort, J. M., Cuzner, M. L., Opdenakker, G.
Format:	Journal Article
Language:	English
Published:	Oxford, UK Blackwell Publishing Ltd 01.02.2006 Blackwell Science
Subjects:	Biological and medical sciences Blotting, Western Brain - blood supply Brain - metabolism Brain - pathology Cell Movement - physiology Cells, Cultured Endothelial Cells - metabolism Flow Cytometry Human viral diseases Humans Immunohistochemistry Infectious diseases Leukocytes, Mononuclear - metabolism Malformations of the nervous system Matrix Metalloproteinase 9 - metabolism Medical sciences MMP-7 MMP-9 multiple sclerosis Multiple Sclerosis - metabolism Multiple Sclerosis - pathology Neurology PECAM-1 Platelet Endothelial Cell Adhesion Molecule-1 - metabolism Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Immunohistochemistry PECAM-1 Multiple sclerosis Nervous system diseases Enzyme Metalloendopeptidases Gelatinase B Inflammatory disease Peptidases Cuff Central nervous system disease Hydrolases Lesion MMP-7 MMP-9
ISSN:	0305-1846, 1365-2990
Online Access:	Get full text
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