The influence of sweet pepper pectin structural characteristics on cytokine secretion by THP-1 macrophages
Pectins can modulate the biological responses interacting directly with immune cells. The observed responses can strongly be affected by polysaccharide structural features. We analyzed the intrinsic activation capacity of native and modified sweet pepper pectin on cytokine secretion by THP-1 macroph...
Uloženo v:
| Vydáno v: | Food research international Ročník 102; s. 588 - 594 |
|---|---|
| Hlavní autoři: | , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
| Vydáno: |
Canada
Elsevier Ltd
01.12.2017
|
| Témata: | |
| ISSN: | 0963-9969, 1873-7145, 1873-7145 |
| On-line přístup: | Získat plný text |
| Tagy: |
Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
|
| Abstract | Pectins can modulate the biological responses interacting directly with immune cells. The observed responses can strongly be affected by polysaccharide structural features. We analyzed the intrinsic activation capacity of native and modified sweet pepper pectin on cytokine secretion by THP-1 macrophages as well as compare their effects in the presence of lipopolysaccharide. Modified pectin was obtained by partial acid hydrolysis which promoted the removal of side chains as well as the reduction of molecular weight and the degree of methyl esterification of native pectin. The results showed that both fractions had no effect on THP-1 viability. Native pectin at 300μg/mL increased TNF-α, IL-1β and IL-10 cytokine secretion by THP-1 macrophages. However, in the presence of lipopolysaccharide, it can attenuate the inflammatory response by reducing the production of the pro-inflammatory cytokines TNF-α and IL-1β and increasing the anti-inflammatory cytokine IL-10, as well as decreasing the TNF-α/IL-10 and IL-1β/IL-10 ratios. The structural modifications caused by acid hydrolysis affected the intrinsic activation capacity of native pectin to modulate the cytokines secretion. These results indicate that degree of methyl esterification, molecular weight and presence of side chains are important structural features of pectins involved in the modulation of cytokine secretion by THP-1 macrophages.
[Display omitted]
•The impact of structural differences of pectin on cytokine secretion was evaluated.•Removal of sweet pepper pectin side chains by partial acid hydrolysis was performed.•Sweet pepper pectins stimulated TNF-α, IL-1β and IL-10 secretion by THP-1 macrophage.•The removal of pectin side chains altered the cytokine secretion profile.•Both native and modified pectins attenuated the inflammatory response triggered by LPS stimulation. |
|---|---|
| AbstractList | Pectins can modulate the biological responses interacting directly with immune cells. The observed responses can strongly be affected by polysaccharide structural features. We analyzed the intrinsic activation capacity of native and modified sweet pepper pectin on cytokine secretion by THP-1 macrophages as well as compare their effects in the presence of lipopolysaccharide. Modified pectin was obtained by partial acid hydrolysis which promoted the removal of side chains as well as the reduction of molecular weight and the degree of methyl esterification of native pectin. The results showed that both fractions had no effect on THP-1 viability. Native pectin at 300μg/mL increased TNF-α, IL-1β and IL-10 cytokine secretion by THP-1 macrophages. However, in the presence of lipopolysaccharide, it can attenuate the inflammatory response by reducing the production of the pro-inflammatory cytokines TNF-α and IL-1β and increasing the anti-inflammatory cytokine IL-10, as well as decreasing the TNF-α/IL-10 and IL-1β/IL-10 ratios. The structural modifications caused by acid hydrolysis affected the intrinsic activation capacity of native pectin to modulate the cytokines secretion. These results indicate that degree of methyl esterification, molecular weight and presence of side chains are important structural features of pectins involved in the modulation of cytokine secretion by THP-1 macrophages.Pectins can modulate the biological responses interacting directly with immune cells. The observed responses can strongly be affected by polysaccharide structural features. We analyzed the intrinsic activation capacity of native and modified sweet pepper pectin on cytokine secretion by THP-1 macrophages as well as compare their effects in the presence of lipopolysaccharide. Modified pectin was obtained by partial acid hydrolysis which promoted the removal of side chains as well as the reduction of molecular weight and the degree of methyl esterification of native pectin. The results showed that both fractions had no effect on THP-1 viability. Native pectin at 300μg/mL increased TNF-α, IL-1β and IL-10 cytokine secretion by THP-1 macrophages. However, in the presence of lipopolysaccharide, it can attenuate the inflammatory response by reducing the production of the pro-inflammatory cytokines TNF-α and IL-1β and increasing the anti-inflammatory cytokine IL-10, as well as decreasing the TNF-α/IL-10 and IL-1β/IL-10 ratios. The structural modifications caused by acid hydrolysis affected the intrinsic activation capacity of native pectin to modulate the cytokines secretion. These results indicate that degree of methyl esterification, molecular weight and presence of side chains are important structural features of pectins involved in the modulation of cytokine secretion by THP-1 macrophages. Pectins can modulate the biological responses interacting directly with immune cells. The observed responses can strongly be affected by polysaccharide structural features. We analyzed the intrinsic activation capacity of native and modified sweet pepper pectin on cytokine secretion by THP-1 macrophages as well as compare their effects in the presence of lipopolysaccharide. Modified pectin was obtained by partial acid hydrolysis which promoted the removal of side chains as well as the reduction of molecular weight and the degree of methyl esterification of native pectin. The results showed that both fractions had no effect on THP-1 viability. Native pectin at 300μg/mL increased TNF-α, IL-1β and IL-10 cytokine secretion by THP-1 macrophages. However, in the presence of lipopolysaccharide, it can attenuate the inflammatory response by reducing the production of the pro-inflammatory cytokines TNF-α and IL-1β and increasing the anti-inflammatory cytokine IL-10, as well as decreasing the TNF-α/IL-10 and IL-1β/IL-10 ratios. The structural modifications caused by acid hydrolysis affected the intrinsic activation capacity of native pectin to modulate the cytokines secretion. These results indicate that degree of methyl esterification, molecular weight and presence of side chains are important structural features of pectins involved in the modulation of cytokine secretion by THP-1 macrophages. [Display omitted] •The impact of structural differences of pectin on cytokine secretion was evaluated.•Removal of sweet pepper pectin side chains by partial acid hydrolysis was performed.•Sweet pepper pectins stimulated TNF-α, IL-1β and IL-10 secretion by THP-1 macrophage.•The removal of pectin side chains altered the cytokine secretion profile.•Both native and modified pectins attenuated the inflammatory response triggered by LPS stimulation. Pectins can modulate the biological responses interacting directly with immune cells. The observed responses can strongly be affected by polysaccharide structural features. We analyzed the intrinsic activation capacity of native and modified sweet pepper pectin on cytokine secretion by THP-1 macrophages as well as compare their effects in the presence of lipopolysaccharide. Modified pectin was obtained by partial acid hydrolysis which promoted the removal of side chains as well as the reduction of molecular weight and the degree of methyl esterification of native pectin. The results showed that both fractions had no effect on THP-1 viability. Native pectin at 300μg/mL increased TNF-α, IL-1β and IL-10 cytokine secretion by THP-1 macrophages. However, in the presence of lipopolysaccharide, it can attenuate the inflammatory response by reducing the production of the pro-inflammatory cytokines TNF-α and IL-1β and increasing the anti-inflammatory cytokine IL-10, as well as decreasing the TNF-α/IL-10 and IL-1β/IL-10 ratios. The structural modifications caused by acid hydrolysis affected the intrinsic activation capacity of native pectin to modulate the cytokines secretion. These results indicate that degree of methyl esterification, molecular weight and presence of side chains are important structural features of pectins involved in the modulation of cytokine secretion by THP-1 macrophages. |
| Author | Cordeiro, Lucimara Mach Côrtes do Nascimento, Georgia Erdmann Ramirez, Marcel Ivan Winnischofer, Sheila Maria Brochado Iacomini, Marcello |
| Author_xml | – sequence: 1 givenname: Georgia Erdmann surname: do Nascimento fullname: do Nascimento, Georgia Erdmann organization: Departamento de Bioquímica e Biologia Molecular, Universidade Federal do Paraná, CP 19.046, CEP 81.531-980 Curitiba, PR, Brazil – sequence: 2 givenname: Sheila Maria Brochado surname: Winnischofer fullname: Winnischofer, Sheila Maria Brochado organization: Departamento de Bioquímica e Biologia Molecular, Universidade Federal do Paraná, CP 19.046, CEP 81.531-980 Curitiba, PR, Brazil – sequence: 3 givenname: Marcel Ivan surname: Ramirez fullname: Ramirez, Marcel Ivan organization: Departamento de Bioquímica e Biologia Molecular, Universidade Federal do Paraná, CP 19.046, CEP 81.531-980 Curitiba, PR, Brazil – sequence: 4 givenname: Marcello surname: Iacomini fullname: Iacomini, Marcello organization: Departamento de Bioquímica e Biologia Molecular, Universidade Federal do Paraná, CP 19.046, CEP 81.531-980 Curitiba, PR, Brazil – sequence: 5 givenname: Lucimara Mach Côrtes surname: Cordeiro fullname: Cordeiro, Lucimara Mach Côrtes email: lucimaramcc@ufpr.br organization: Departamento de Bioquímica e Biologia Molecular, Universidade Federal do Paraná, CP 19.046, CEP 81.531-980 Curitiba, PR, Brazil |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/29195989$$D View this record in MEDLINE/PubMed |
| BookMark | eNqFkc1u1DAURq2qqJ0WHqHISzYJdn7ssVggVNEWqRIshrXl3Fx3PGTiYDugeXsczXTDZlZXss93LX_nhlyOfkRC7jgrOePi46603vcBY1kxLkumSlbLC7Lia1kXkjftJVkxJepCKaGuyU2MO8aYaKW6IteV4qpVa7Uiu80WqRvtMOMISL2l8S9iohNOE4Y8ILmRxhRmSHMwA4WtCQYSBheTg0j9SOGQ_C83Io0IAZPLR92Bbp5-FJzuDQQ_bc0LxrfkjTVDxHeneUt-Pnzd3D8Vz98fv91_eS6gEU0qbMWgajhaDihlawSyurdMtV1XyXwh0TDVKNsKYZhVWLXN2oLtRNMAVL2ob8mH494p-N8zxqT3LgIOgxnRz1FXSw9MccHPolxJLhlXosno-xM6d3vs9RTc3oSDfq0yA5-OQP5wjAGtBpfM0kYKxg2aM72I0zt9EqcXcZopncXldPtf-vWBc7nPxxzmRv84DDqCW1T2LmR3uvfuzIZ_R6O2wA |
| CitedBy_id | crossref_primary_10_1038_s12276_020_0449_2 crossref_primary_10_1016_j_jneuroim_2025_578696 crossref_primary_10_1039_C9FO02221J crossref_primary_10_1016_j_foodres_2021_110675 crossref_primary_10_1016_j_ijbiomac_2023_124281 crossref_primary_10_1080_14620316_2022_2046508 crossref_primary_10_1016_j_bcdf_2021_100283 crossref_primary_10_1016_j_ijbiomac_2018_05_083 crossref_primary_10_3389_fimmu_2018_01504 crossref_primary_10_1155_2018_5417165 crossref_primary_10_1016_j_ijbiomac_2022_04_073 crossref_primary_10_3389_fimmu_2024_1406213 crossref_primary_10_1016_j_carbpol_2023_121554 crossref_primary_10_1007_s10719_021_09982_y crossref_primary_10_1016_j_ijbiomac_2024_137731 crossref_primary_10_1016_j_carbpol_2020_117388 crossref_primary_10_1016_j_aqrep_2024_102547 crossref_primary_10_1016_j_foodres_2023_113743 crossref_primary_10_1016_j_ijbiomac_2025_145713 crossref_primary_10_1016_j_carbpol_2021_118319 crossref_primary_10_1016_j_ijbiomac_2025_141258 crossref_primary_10_3389_fpls_2021_623723 crossref_primary_10_3390_polym10121407 crossref_primary_10_31146_1682_8658_ecg_223_3_119_133 crossref_primary_10_1399_eps_2020_323 crossref_primary_10_3233_JBR_190485 crossref_primary_10_3390_molecules28247974 crossref_primary_10_1016_j_fbio_2023_103386 crossref_primary_10_1111_1541_4337_12723 crossref_primary_10_1080_10408398_2023_2290230 crossref_primary_10_1016_j_ijbiomac_2024_138344 crossref_primary_10_1080_10408398_2023_2173719 crossref_primary_10_1016_j_carbpol_2020_117177 crossref_primary_10_1016_j_ijbiomac_2022_05_074 crossref_primary_10_1016_j_foodhyd_2023_108495 crossref_primary_10_1016_j_ijbiomac_2021_03_202 crossref_primary_10_1016_j_ijbiomac_2025_146954 crossref_primary_10_3390_ijms242316653 crossref_primary_10_1111_1750_3841_17438 crossref_primary_10_1016_j_bcdf_2021_100301 crossref_primary_10_1016_j_carbpol_2020_117514 crossref_primary_10_3390_biom12020289 |
| Cites_doi | 10.1124/jpet.105.085415 10.1038/srep40402 10.1016/j.carbpol.2010.01.040 10.1016/j.carbpol.2016.02.017 10.1134/S0006297913070134 10.1016/j.ijbiomac.2016.08.015 10.1016/j.intimp.2014.08.002 10.1016/j.intimp.2005.10.005 10.1039/C3FO60410A 10.4049/jimmunol.1502178 10.1016/j.jim.2016.01.012 10.1038/nchembio.439 10.1615/CritRevImmunol.v27.i2.10 10.1016/S0006-2952(97)00547-9 10.1097/MCO.0b013e32833eebe5 10.1007/s00011-007-6115-5 10.1093/jn/134.5.1181 10.1046/j.1365-2567.1999.00774.x 10.1016/S0162-3109(00)00245-9 10.1016/j.ijbiomac.2016.01.048 10.1039/c0fo00113a 10.1016/j.biopha.2008.07.058 10.1371/journal.pone.0078051 10.1016/j.jff.2016.02.002 10.1016/j.carbpol.2012.03.039 10.1016/j.carbpol.2017.07.073 10.1016/j.foodchem.2012.11.091 10.1111/j.1749-6632.2009.05256.x 10.1016/j.plaphy.2016.04.055 10.1016/j.bcp.2006.07.001 10.1055/s-2006-957898 10.1016/j.carbpol.2017.07.011 10.3945/ajcn.112.040808 10.1093/carcin/bgq070 10.1016/j.carbpol.2016.04.097 10.1016/j.carbpol.2011.11.073 10.1016/j.intimp.2008.06.003 10.1177/014860719902300518 10.1016/j.foodchem.2010.06.038 |
| ContentType | Journal Article |
| Copyright | 2017 Elsevier Ltd Copyright © 2017 Elsevier Ltd. All rights reserved. |
| Copyright_xml | – notice: 2017 Elsevier Ltd – notice: Copyright © 2017 Elsevier Ltd. All rights reserved. |
| DBID | AAYXX CITATION NPM 7X8 7S9 L.6 |
| DOI | 10.1016/j.foodres.2017.09.037 |
| DatabaseName | CrossRef PubMed MEDLINE - Academic AGRICOLA AGRICOLA - Academic |
| DatabaseTitle | CrossRef PubMed MEDLINE - Academic AGRICOLA AGRICOLA - Academic |
| DatabaseTitleList | MEDLINE - Academic PubMed AGRICOLA |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Economics Engineering |
| EISSN | 1873-7145 |
| EndPage | 594 |
| ExternalDocumentID | 29195989 10_1016_j_foodres_2017_09_037 S096399691730604X |
| Genre | Research Support, Non-U.S. Gov't Journal Article |
| GroupedDBID | --K --M .GJ .~1 0R~ 1B1 1RT 1~. 1~5 29H 4.4 457 4G. 53G 5GY 5VS 7-5 71M 8P~ 9JM AABNK AABVA AACTN AAEDT AAEDW AAIAV AAIKC AAIKJ AAKOC AALCJ AALRI AAMNW AAOAW AAQFI AAQXK AATLK AAXUO ABFNM ABFRF ABGRD ABMAC ABXDB ABYKQ ACDAQ ACGFO ACIUM ACRLP ADBBV ADEZE ADMUD ADQTV AEBSH AEFWE AEKER AENEX AEQOU AFKWA AFTJW AFXIZ AGHFR AGUBO AGYEJ AHHHB AIEXJ AIKHN AITUG AJBFU AJOXV ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ ASPBG AVWKF AXJTR AZFZN BKOJK BLXMC CBWCG CS3 DU5 EBS EFJIC EFLBG EJD EO8 EO9 EP2 EP3 F5P FDB FEDTE FGOYB FIRID FNPLU FYGXN G-2 G-Q GBLVA HLV HVGLF HZ~ IHE J1W K-O KOM LW9 M41 MO0 N9A O-L O9- OAUVE OZT P-8 P-9 P2P PC. Q38 R2- RIG ROL RPZ SAB SDF SDG SDP SES SEW SPCBC SSA SSZ T5K WUQ Y6R ~G- ~KM 9DU AAHBH AATTM AAXKI AAYWO AAYXX ABUFD ABWVN ACLOT ACRPL ACVFH ADCNI ADNMO AEIPS AEUPX AFJKZ AFPUW AGQPQ AIGII AIIUN AKBMS AKRWK AKYEP ANKPU APXCP CITATION EFKBS ~HD BNPGV NPM SSH 7X8 7S9 L.6 |
| ID | FETCH-LOGICAL-c464t-f20c241ef1ce775a6e03df095bb272417ea0949f566a0f9e2548fcfb644cc2d63 |
| ISICitedReferencesCount | 42 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000419418100069&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 0963-9969 1873-7145 |
| IngestDate | Wed Oct 01 13:57:33 EDT 2025 Sun Nov 09 10:13:34 EST 2025 Thu Apr 03 07:08:45 EDT 2025 Tue Nov 18 21:03:52 EST 2025 Sat Nov 29 04:33:38 EST 2025 Fri Feb 23 02:30:01 EST 2024 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Keywords | Cytokine secretion Immunomodulatory activity THP-1 macrophages Structure-function relationship Sweet pepper pectin |
| Language | English |
| License | Copyright © 2017 Elsevier Ltd. All rights reserved. |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c464t-f20c241ef1ce775a6e03df095bb272417ea0949f566a0f9e2548fcfb644cc2d63 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| PMID | 29195989 |
| PQID | 1971701964 |
| PQPubID | 23479 |
| PageCount | 7 |
| ParticipantIDs | proquest_miscellaneous_2000609161 proquest_miscellaneous_1971701964 pubmed_primary_29195989 crossref_citationtrail_10_1016_j_foodres_2017_09_037 crossref_primary_10_1016_j_foodres_2017_09_037 elsevier_sciencedirect_doi_10_1016_j_foodres_2017_09_037 |
| PublicationCentury | 2000 |
| PublicationDate | December 2017 2017-12-00 20171201 |
| PublicationDateYYYYMMDD | 2017-12-01 |
| PublicationDate_xml | – month: 12 year: 2017 text: December 2017 |
| PublicationDecade | 2010 |
| PublicationPlace | Canada |
| PublicationPlace_xml | – name: Canada |
| PublicationTitle | Food research international |
| PublicationTitleAlternate | Food Res Int |
| PublicationYear | 2017 |
| Publisher | Elsevier Ltd |
| Publisher_xml | – name: Elsevier Ltd |
| References | Amorim, Vriesmann, Petkowicz, Martinez, Noleto (bb0010) 2016; 92 Suh, Yang, Ra, Noh, Kwon, Hwang, Yu (bb0150) 2013; 138 Wismar, Brix, Frøkiær, Lærke (bb0180) 2010; 1190 Guo, Matsumoto, Kikuchi, Ikejima, Wang, Yamada (bb0055) 2000; 49 Popov, Ovodov (bb0100) 2013; 78 Chanput, Mes, Wichers (bb0030) 2014; 23 Landberg (bb0060) 2012; 96 Wang, Xie, Yang, Zhang, Wang, Wu, Xie (bb0175) 2017; 7 Peters, Guidato, Peters, Megger, Sitek, Classen, Bufe (bb0095) 2016; 196 Zhang, Li, Sun, Ji, Zhu, Fan, Zhou (bb0195) 2012; 89 Andoh, Bamba, Sasaki (bb0015) 1999; 23 Burton, Gidley, Fincher (bb0020) 2010; 6 Wu, Lu, Jiang, Li, Huang (bb0185) 2014; 5 Sakurai, Matsumoto, Kiyohara, Yamada (bb0125) 1999; 97 Chanput, Mes, Vreeburg, Savelkoul, Wichers (bb0025) 2010; 1 Sakurai, Matsumoto, Kiyohara, Yamada (bb0120) 1996; 62 Ajani, Ford, Mokdad (bb0005) 2004; 134 Freysdottir, Logadottir, Omarsdottir, Vikingsson, Hardardottir (bb0040) 2016; 143 de Santana-Filho, Noleto, Gorin, de Souza, Iacomini, Sassaki (bb0135) 2012; 87 Wu, Zhang, Guo, Li, Chen (bb0190) 2013; 8 Wang, Luo, Zha (bb0170) 2010; 81 Chen, Sheu, Chen, Wang, Hou, Liu, Liang (bb0035) 2006; 72 Georgiev, Paulsen, Kiyohara, Ciz, Ognyanov, Vasicek, Kratchanova (bb0045) 2017; 175 Rice, Adams, Ozment-Skelton, Gonzalez, Goldman, Lockhart, Williams (bb0115) 2005; 314 Lund, To, O'Brien, Donnelly (bb0070) 2016; 430 Liu, Li, Niu, Sun, Guo, Li, Mei (bb0065) 2010; 31 Meijer, de Vos, Priebe (bb0080) 2010; 13 Georgiev, Paulsen, Kiyohara, Ciz, Ognyanov, Vasicek, Kratchanova (bb0050) 2017; 174 Vogt, Sahasrabudhe, Ramasamy, Meyer, Pullens, Faas, de Vos (bb0160) 2016; 22 Vos, M'Rabet, Stahl, Boehm, Garssen (bb0165) 2007; 27 Popov, Ovodova, Golovchenko, Popova, Viatyasev, Shashkov, Ovodov (bb0105) 2011; 124 Tamiello, do Nascimento, Iacomini, Cordeiro (bb0155) 2017 Park, Jung, Yang, Yoo, Kim, Kim (bb0090) 2007; 56 Schepetkin, Xie, Kirpotina, Klein, Jutila, Quinn (bb0145) 2008; 8 Lv, Chen, Yang, Zhu, Li, Zhao, Zhang (bb0075) 2016; 86 do Nascimento, Iacomini, Cordeiro (bb0085) 2016; 104 Reilly, Bellevue Iii, Woster, Svensson (bb0110) 1998; 55 Salman, Bergman, Djaldetti, Orlin, Bessler (bb0130) 2008; 62 Schepetkin, Quinn (bb0140) 2006; 6 Zhang, Qi, Guo, Zhou, Zhang (bb0200) 2016; 149 Tamiello (10.1016/j.foodres.2017.09.037_bb0155) 2017 Vogt (10.1016/j.foodres.2017.09.037_bb0160) 2016; 22 Lv (10.1016/j.foodres.2017.09.037_bb0075) 2016; 86 Andoh (10.1016/j.foodres.2017.09.037_bb0015) 1999; 23 Reilly (10.1016/j.foodres.2017.09.037_bb0110) 1998; 55 Suh (10.1016/j.foodres.2017.09.037_bb0150) 2013; 138 do Nascimento (10.1016/j.foodres.2017.09.037_bb0085) 2016; 104 Freysdottir (10.1016/j.foodres.2017.09.037_bb0040) 2016; 143 Georgiev (10.1016/j.foodres.2017.09.037_bb0050) 2017; 174 Burton (10.1016/j.foodres.2017.09.037_bb0020) 2010; 6 Sakurai (10.1016/j.foodres.2017.09.037_bb0120) 1996; 62 Chanput (10.1016/j.foodres.2017.09.037_bb0025) 2010; 1 Popov (10.1016/j.foodres.2017.09.037_bb0105) 2011; 124 Chanput (10.1016/j.foodres.2017.09.037_bb0030) 2014; 23 Guo (10.1016/j.foodres.2017.09.037_bb0055) 2000; 49 Schepetkin (10.1016/j.foodres.2017.09.037_bb0140) 2006; 6 Rice (10.1016/j.foodres.2017.09.037_bb0115) 2005; 314 Amorim (10.1016/j.foodres.2017.09.037_bb0010) 2016; 92 Wang (10.1016/j.foodres.2017.09.037_bb0170) 2010; 81 Landberg (10.1016/j.foodres.2017.09.037_bb0060) 2012; 96 Lund (10.1016/j.foodres.2017.09.037_bb0070) 2016; 430 Salman (10.1016/j.foodres.2017.09.037_bb0130) 2008; 62 Georgiev (10.1016/j.foodres.2017.09.037_bb0045) 2017; 175 Schepetkin (10.1016/j.foodres.2017.09.037_bb0145) 2008; 8 Wismar (10.1016/j.foodres.2017.09.037_bb0180) 2010; 1190 Popov (10.1016/j.foodres.2017.09.037_bb0100) 2013; 78 Liu (10.1016/j.foodres.2017.09.037_bb0065) 2010; 31 Zhang (10.1016/j.foodres.2017.09.037_bb0195) 2012; 89 Wu (10.1016/j.foodres.2017.09.037_bb0190) 2013; 8 Zhang (10.1016/j.foodres.2017.09.037_bb0200) 2016; 149 Vos (10.1016/j.foodres.2017.09.037_bb0165) 2007; 27 Wu (10.1016/j.foodres.2017.09.037_bb0185) 2014; 5 Ajani (10.1016/j.foodres.2017.09.037_bb0005) 2004; 134 de Santana-Filho (10.1016/j.foodres.2017.09.037_bb0135) 2012; 87 Sakurai (10.1016/j.foodres.2017.09.037_bb0125) 1999; 97 Park (10.1016/j.foodres.2017.09.037_bb0090) 2007; 56 Peters (10.1016/j.foodres.2017.09.037_bb0095) 2016; 196 Wang (10.1016/j.foodres.2017.09.037_bb0175) 2017; 7 Meijer (10.1016/j.foodres.2017.09.037_bb0080) 2010; 13 Chen (10.1016/j.foodres.2017.09.037_bb0035) 2006; 72 |
| References_xml | – volume: 6 start-page: 724 year: 2010 end-page: 732 ident: bb0020 article-title: Heterogeneity in the chemistry, structure and function of plant cell walls publication-title: Nature Chemical Biology – volume: 7 start-page: 40402 year: 2017 ident: bb0175 article-title: Sulfated publication-title: Scientific Reports – volume: 196 start-page: 1626 year: 2016 end-page: 1635 ident: bb0095 article-title: Allergy-protective arabinogalactan modulates human dendritic cells via C-type lectins and inhibition of NF-κB publication-title: The Journal of Immunology – volume: 8 start-page: 1455 year: 2008 end-page: 1466 ident: bb0145 article-title: Macrophage immunomodulatory activity of polysaccharides isolated from publication-title: International Immunopharmacology – volume: 56 start-page: 45 year: 2007 end-page: 50 ident: bb0090 article-title: Optimized THP-1 differentiation is required for the detection of responses to weak stimuli publication-title: Inflammation Research – volume: 87 start-page: 2730 year: 2012 end-page: 2734 ident: bb0135 article-title: GC–MS detection and quantification of lipopolysaccharides in polysaccharides through 3-O-acetyl fatty acid methyl esters publication-title: Carbohydrate Polymers – volume: 138 start-page: 1079 year: 2013 end-page: 1086 ident: bb0150 article-title: Peyer's patch-mediated intestinal immune system modulating activity of pectic-type polysaccharide from peel of publication-title: Food Chemistry – volume: 92 start-page: 1040 year: 2016 end-page: 1048 ident: bb0010 article-title: Modified pectin from publication-title: International Journal of Biological Macromolecules – volume: 55 start-page: 803 year: 1998 end-page: 810 ident: bb0110 article-title: Comparison of the in vitro cytotoxicity of hydroxylamine metabolites of sulfamethoxazole and dapsone publication-title: Biochemical Pharmacology – volume: 89 start-page: 519 year: 2012 end-page: 525 ident: bb0195 article-title: Further analysis of the structure and immunological activity of an RG-I type pectin from publication-title: Carbohydrate Polymers – volume: 13 start-page: 715 year: 2010 end-page: 721 ident: bb0080 article-title: Butyrate and other short-chain fatty acids as modulators of immunity: What relevance for health? publication-title: Current Opinion in Clinical Nutrition and Metabolic Care – volume: 27 start-page: 97 year: 2007 end-page: 140 ident: bb0165 article-title: Immune-modulatory effects and potential working mechanisms of orally applied nondigestible carbohydrates publication-title: Critical Reviews in Immunology – volume: 86 start-page: 28 year: 2016 end-page: 42 ident: bb0075 article-title: Comparative studies on the immunoregulatory effects of three polysaccharides using high content imaging system publication-title: International Journal of Biological Macromolecules – volume: 22 start-page: 398 year: 2016 end-page: 407 ident: bb0160 article-title: The impact of lemon pectin characteristics on TLR activation and T84 intestinal epithelial cell barrier function publication-title: Journal of Functional Foods – volume: 62 start-page: 579 year: 2008 end-page: 582 ident: bb0130 article-title: Citrus pectin affects cytokine production by human peripheral blood mononuclear cells publication-title: Biomedicine & Pharmacotherapy – volume: 23 start-page: S70 year: 1999 end-page: S73 ident: bb0015 article-title: Physiological and anti-inflammatory roles of dietary fiber and butyrate in intestinal functions publication-title: Journal of Parenteral and Enteral Nutrition – volume: 104 start-page: 278 year: 2016 end-page: 283 ident: bb0085 article-title: A comparative study of mucilage and pulp polysaccharides from tamarillo fruit ( publication-title: Plant Physiology and Biochemistry – volume: 78 start-page: 823 year: 2013 end-page: 835 ident: bb0100 article-title: Polypotency of the immunomodulatory effect of pectins publication-title: Biochemistry (Moscow) – volume: 149 start-page: 186 year: 2016 end-page: 206 ident: bb0200 article-title: Toll-like receptor 4-related immunostimulatory polysaccharides: Primary structure, activity relationships, and possible interaction models publication-title: Carbohydrate Polymers – volume: 175 start-page: 178 year: 2017 end-page: 191 ident: bb0045 article-title: pectins exhibit dual mode of action on phagocytes as β-glucuronic acid monomers are abundant in their rhamnogalacturonans I publication-title: Carbohydrate Polymers – volume: 97 start-page: 540 year: 1999 end-page: 547 ident: bb0125 article-title: B-cell proliferation activity of pectic polysaccharide from a medicinal herb, the roots of publication-title: Immunology – volume: 1 start-page: 254 year: 2010 end-page: 261 ident: bb0025 article-title: Transcription profiles of LPS-stimulated THP-1 monocytes and macrophages: A tool to study inflammation modulating effects of food-derived compounds publication-title: Food & Function – volume: 124 start-page: 309 year: 2011 end-page: 315 ident: bb0105 article-title: Chemical composition and anti-inflammatory activity of a pectic polysaccharide isolated from sweet pepper using a simulated gastric medium publication-title: Food Chemistry – volume: 81 start-page: 1 year: 2010 end-page: 7 ident: bb0170 article-title: Structural features of a pectic polysaccharide from the stems of publication-title: Carbohydrate Polymers – volume: 314 start-page: 1079 year: 2005 end-page: 1086 ident: bb0115 article-title: Oral delivery and gastrointestinal absorption of soluble glucans stimulate increased resistance to infectious challenge publication-title: Journal of Pharmacology and Experimental Therapeutics – volume: 1190 start-page: 70 year: 2010 end-page: 85 ident: bb0180 article-title: Dietary fibers as immunoregulatory compounds in health and disease publication-title: Annals of the New York Academy of Sciences – volume: 430 start-page: 64 year: 2016 end-page: 70 ident: bb0070 article-title: The choice of phorbol 12-myristate 13-acetate differentiation protocol influences the response of THP-1 macrophages to a pro-inflammatory stimulus publication-title: Journal of Immunological Methods – volume: 174 start-page: 948 year: 2017 end-page: 959 ident: bb0050 article-title: The common lavender ( publication-title: Carbohydrate Polymers – volume: 6 start-page: 317 year: 2006 end-page: 333 ident: bb0140 article-title: Botanical polysaccharides: Macrophage immunomodulation and therapeutic potential publication-title: International Immunopharmacology – volume: 8 year: 2013 ident: bb0190 article-title: Bupleurum polysaccharides attenuates lipopolysaccharide-induced inflammation via modulating Toll-like receptor 4 signaling publication-title: PloS One – volume: 134 start-page: 1181 year: 2004 end-page: 1185 ident: bb0005 article-title: Dietary fiber and C-reactive protein: Findings from national health and nutrition examination survey data publication-title: The Journal of Nutrition – volume: 31 start-page: 1822 year: 2010 end-page: 1832 ident: bb0065 article-title: An apple oligogalactan prevents against inflammation and carcinogenesis by targeting LPS/TLR4/NF-κB pathway in a mouse model of colitis-associated colon cancer publication-title: Carcinogenesis – volume: 62 start-page: 341 year: 1996 end-page: 346 ident: bb0120 article-title: Detection and tissue distribution of anti-ulcer pectic polysaccharides from publication-title: Planta Medica – volume: 49 start-page: 307 year: 2000 end-page: 316 ident: bb0055 article-title: Effects of a pectic polysaccharide from a medicinal herb, the roots of publication-title: Immunopharmacology – volume: 72 start-page: 1001 year: 2006 end-page: 1009 ident: bb0035 article-title: Suppression of endotoxin-induced proinflammatory responses by citrus pectin through blocking LPS signaling pathways publication-title: Biochemical Pharmacology – volume: 143 start-page: 131 year: 2016 end-page: 138 ident: bb0040 article-title: A polysaccharide fraction from publication-title: Carbohydrate Polymers – year: 2017 ident: bb0155 article-title: Arabinogalactan from edible jambo fruit induces different responses on cytokine secretion by THP-1 macrophages in the absence and presence of proinflammatory stimulus publication-title: International Journal of Biological Macromolecules – volume: 5 start-page: 337 year: 2014 end-page: 344 ident: bb0185 article-title: Regulation effect of polysaccharides from publication-title: Food & Function – volume: 23 start-page: 37 year: 2014 end-page: 45 ident: bb0030 article-title: THP-1 cell line: An in vitro cell model for immune modulation approach publication-title: International Immunopharmacology – volume: 96 start-page: 3 year: 2012 end-page: 4 ident: bb0060 article-title: Dietary fiber and mortality: Convincing observations that call for mechanistic investigations publication-title: The American Journal of Clinical Nutrition – volume: 314 start-page: 1079 issue: 3 year: 2005 ident: 10.1016/j.foodres.2017.09.037_bb0115 article-title: Oral delivery and gastrointestinal absorption of soluble glucans stimulate increased resistance to infectious challenge publication-title: Journal of Pharmacology and Experimental Therapeutics doi: 10.1124/jpet.105.085415 – volume: 7 start-page: 40402 year: 2017 ident: 10.1016/j.foodres.2017.09.037_bb0175 article-title: Sulfated Cyclocarya paliurus polysaccharides markedly attenuates inflammation and oxidative damage in lipopolysaccharide-treated macrophage cells and mice publication-title: Scientific Reports doi: 10.1038/srep40402 – volume: 81 start-page: 1 issue: 1 year: 2010 ident: 10.1016/j.foodres.2017.09.037_bb0170 article-title: Structural features of a pectic polysaccharide from the stems of Dendrobium nobile Lindl publication-title: Carbohydrate Polymers doi: 10.1016/j.carbpol.2010.01.040 – volume: 143 start-page: 131 year: 2016 ident: 10.1016/j.foodres.2017.09.037_bb0040 article-title: A polysaccharide fraction from Achillea millefolium increases cytokine secretion and reduces activation of Akt, ERK and NF-κB in THP-1 monocytes publication-title: Carbohydrate Polymers doi: 10.1016/j.carbpol.2016.02.017 – volume: 78 start-page: 823 issue: 7 year: 2013 ident: 10.1016/j.foodres.2017.09.037_bb0100 article-title: Polypotency of the immunomodulatory effect of pectins publication-title: Biochemistry (Moscow) doi: 10.1134/S0006297913070134 – volume: 92 start-page: 1040 year: 2016 ident: 10.1016/j.foodres.2017.09.037_bb0010 article-title: Modified pectin from Theobroma cacao induces potent pro-inflammatory activity in murine peritoneal macrophage publication-title: International Journal of Biological Macromolecules doi: 10.1016/j.ijbiomac.2016.08.015 – volume: 23 start-page: 37 issue: 1 year: 2014 ident: 10.1016/j.foodres.2017.09.037_bb0030 article-title: THP-1 cell line: An in vitro cell model for immune modulation approach publication-title: International Immunopharmacology doi: 10.1016/j.intimp.2014.08.002 – volume: 6 start-page: 317 issue: 3 year: 2006 ident: 10.1016/j.foodres.2017.09.037_bb0140 article-title: Botanical polysaccharides: Macrophage immunomodulation and therapeutic potential publication-title: International Immunopharmacology doi: 10.1016/j.intimp.2005.10.005 – volume: 5 start-page: 337 issue: 2 year: 2014 ident: 10.1016/j.foodres.2017.09.037_bb0185 article-title: Regulation effect of polysaccharides from Pleurotus tuber-regium (Fr.) on the immune activity of mice macrophages publication-title: Food & Function doi: 10.1039/C3FO60410A – volume: 196 start-page: 1626 issue: 4 year: 2016 ident: 10.1016/j.foodres.2017.09.037_bb0095 article-title: Allergy-protective arabinogalactan modulates human dendritic cells via C-type lectins and inhibition of NF-κB publication-title: The Journal of Immunology doi: 10.4049/jimmunol.1502178 – volume: 430 start-page: 64 year: 2016 ident: 10.1016/j.foodres.2017.09.037_bb0070 article-title: The choice of phorbol 12-myristate 13-acetate differentiation protocol influences the response of THP-1 macrophages to a pro-inflammatory stimulus publication-title: Journal of Immunological Methods doi: 10.1016/j.jim.2016.01.012 – volume: 6 start-page: 724 issue: 10 year: 2010 ident: 10.1016/j.foodres.2017.09.037_bb0020 article-title: Heterogeneity in the chemistry, structure and function of plant cell walls publication-title: Nature Chemical Biology doi: 10.1038/nchembio.439 – volume: 27 start-page: 97 issue: 2 year: 2007 ident: 10.1016/j.foodres.2017.09.037_bb0165 article-title: Immune-modulatory effects and potential working mechanisms of orally applied nondigestible carbohydrates publication-title: Critical Reviews in Immunology doi: 10.1615/CritRevImmunol.v27.i2.10 – volume: 55 start-page: 803 issue: 6 year: 1998 ident: 10.1016/j.foodres.2017.09.037_bb0110 article-title: Comparison of the in vitro cytotoxicity of hydroxylamine metabolites of sulfamethoxazole and dapsone publication-title: Biochemical Pharmacology doi: 10.1016/S0006-2952(97)00547-9 – volume: 13 start-page: 715 issue: 6 year: 2010 ident: 10.1016/j.foodres.2017.09.037_bb0080 article-title: Butyrate and other short-chain fatty acids as modulators of immunity: What relevance for health? publication-title: Current Opinion in Clinical Nutrition and Metabolic Care doi: 10.1097/MCO.0b013e32833eebe5 – volume: 56 start-page: 45 issue: 1 year: 2007 ident: 10.1016/j.foodres.2017.09.037_bb0090 article-title: Optimized THP-1 differentiation is required for the detection of responses to weak stimuli publication-title: Inflammation Research doi: 10.1007/s00011-007-6115-5 – year: 2017 ident: 10.1016/j.foodres.2017.09.037_bb0155 article-title: Arabinogalactan from edible jambo fruit induces different responses on cytokine secretion by THP-1 macrophages in the absence and presence of proinflammatory stimulus publication-title: International Journal of Biological Macromolecules – volume: 134 start-page: 1181 issue: 5 year: 2004 ident: 10.1016/j.foodres.2017.09.037_bb0005 article-title: Dietary fiber and C-reactive protein: Findings from national health and nutrition examination survey data publication-title: The Journal of Nutrition doi: 10.1093/jn/134.5.1181 – volume: 97 start-page: 540 issue: 3 year: 1999 ident: 10.1016/j.foodres.2017.09.037_bb0125 article-title: B-cell proliferation activity of pectic polysaccharide from a medicinal herb, the roots of Bupleurum falcatum L. and its structural requirement publication-title: Immunology doi: 10.1046/j.1365-2567.1999.00774.x – volume: 49 start-page: 307 issue: 3 year: 2000 ident: 10.1016/j.foodres.2017.09.037_bb0055 article-title: Effects of a pectic polysaccharide from a medicinal herb, the roots of Bupleurum falcatum L. on interleukin 6 production of murine B cells and B cell lines publication-title: Immunopharmacology doi: 10.1016/S0162-3109(00)00245-9 – volume: 86 start-page: 28 year: 2016 ident: 10.1016/j.foodres.2017.09.037_bb0075 article-title: Comparative studies on the immunoregulatory effects of three polysaccharides using high content imaging system publication-title: International Journal of Biological Macromolecules doi: 10.1016/j.ijbiomac.2016.01.048 – volume: 1 start-page: 254 issue: 3 year: 2010 ident: 10.1016/j.foodres.2017.09.037_bb0025 article-title: Transcription profiles of LPS-stimulated THP-1 monocytes and macrophages: A tool to study inflammation modulating effects of food-derived compounds publication-title: Food & Function doi: 10.1039/c0fo00113a – volume: 62 start-page: 579 issue: 9 year: 2008 ident: 10.1016/j.foodres.2017.09.037_bb0130 article-title: Citrus pectin affects cytokine production by human peripheral blood mononuclear cells publication-title: Biomedicine & Pharmacotherapy doi: 10.1016/j.biopha.2008.07.058 – volume: 8 issue: 10 year: 2013 ident: 10.1016/j.foodres.2017.09.037_bb0190 article-title: Bupleurum polysaccharides attenuates lipopolysaccharide-induced inflammation via modulating Toll-like receptor 4 signaling publication-title: PloS One doi: 10.1371/journal.pone.0078051 – volume: 22 start-page: 398 year: 2016 ident: 10.1016/j.foodres.2017.09.037_bb0160 article-title: The impact of lemon pectin characteristics on TLR activation and T84 intestinal epithelial cell barrier function publication-title: Journal of Functional Foods doi: 10.1016/j.jff.2016.02.002 – volume: 89 start-page: 519 issue: 2 year: 2012 ident: 10.1016/j.foodres.2017.09.037_bb0195 article-title: Further analysis of the structure and immunological activity of an RG-I type pectin from Panax ginseng publication-title: Carbohydrate Polymers doi: 10.1016/j.carbpol.2012.03.039 – volume: 175 start-page: 178 year: 2017 ident: 10.1016/j.foodres.2017.09.037_bb0045 article-title: Tilia tomentosa pectins exhibit dual mode of action on phagocytes as β-glucuronic acid monomers are abundant in their rhamnogalacturonans I publication-title: Carbohydrate Polymers doi: 10.1016/j.carbpol.2017.07.073 – volume: 138 start-page: 1079 issue: 2–3 year: 2013 ident: 10.1016/j.foodres.2017.09.037_bb0150 article-title: Peyer's patch-mediated intestinal immune system modulating activity of pectic-type polysaccharide from peel of Citrus unshiu publication-title: Food Chemistry doi: 10.1016/j.foodchem.2012.11.091 – volume: 1190 start-page: 70 issue: 1 year: 2010 ident: 10.1016/j.foodres.2017.09.037_bb0180 article-title: Dietary fibers as immunoregulatory compounds in health and disease publication-title: Annals of the New York Academy of Sciences doi: 10.1111/j.1749-6632.2009.05256.x – volume: 104 start-page: 278 year: 2016 ident: 10.1016/j.foodres.2017.09.037_bb0085 article-title: A comparative study of mucilage and pulp polysaccharides from tamarillo fruit (Solanum betaceum Cav.) publication-title: Plant Physiology and Biochemistry doi: 10.1016/j.plaphy.2016.04.055 – volume: 72 start-page: 1001 issue: 8 year: 2006 ident: 10.1016/j.foodres.2017.09.037_bb0035 article-title: Suppression of endotoxin-induced proinflammatory responses by citrus pectin through blocking LPS signaling pathways publication-title: Biochemical Pharmacology doi: 10.1016/j.bcp.2006.07.001 – volume: 62 start-page: 341 issue: 4 year: 1996 ident: 10.1016/j.foodres.2017.09.037_bb0120 article-title: Detection and tissue distribution of anti-ulcer pectic polysaccharides from Bupleurum falcatum by a polyclonal antibody publication-title: Planta Medica doi: 10.1055/s-2006-957898 – volume: 174 start-page: 948 year: 2017 ident: 10.1016/j.foodres.2017.09.037_bb0050 article-title: The common lavender (Lavandula angustifolia Mill.) pectic polysaccharides modulate phagocytic leukocytes and intestinal Peyer's patch cells publication-title: Carbohydrate Polymers doi: 10.1016/j.carbpol.2017.07.011 – volume: 96 start-page: 3 issue: 1 year: 2012 ident: 10.1016/j.foodres.2017.09.037_bb0060 article-title: Dietary fiber and mortality: Convincing observations that call for mechanistic investigations publication-title: The American Journal of Clinical Nutrition doi: 10.3945/ajcn.112.040808 – volume: 31 start-page: 1822 issue: 10 year: 2010 ident: 10.1016/j.foodres.2017.09.037_bb0065 article-title: An apple oligogalactan prevents against inflammation and carcinogenesis by targeting LPS/TLR4/NF-κB pathway in a mouse model of colitis-associated colon cancer publication-title: Carcinogenesis doi: 10.1093/carcin/bgq070 – volume: 149 start-page: 186 year: 2016 ident: 10.1016/j.foodres.2017.09.037_bb0200 article-title: Toll-like receptor 4-related immunostimulatory polysaccharides: Primary structure, activity relationships, and possible interaction models publication-title: Carbohydrate Polymers doi: 10.1016/j.carbpol.2016.04.097 – volume: 87 start-page: 2730 year: 2012 ident: 10.1016/j.foodres.2017.09.037_bb0135 article-title: GC–MS detection and quantification of lipopolysaccharides in polysaccharides through 3-O-acetyl fatty acid methyl esters publication-title: Carbohydrate Polymers doi: 10.1016/j.carbpol.2011.11.073 – volume: 8 start-page: 1455 issue: 10 year: 2008 ident: 10.1016/j.foodres.2017.09.037_bb0145 article-title: Macrophage immunomodulatory activity of polysaccharides isolated from Opuntia polyacantha publication-title: International Immunopharmacology doi: 10.1016/j.intimp.2008.06.003 – volume: 23 start-page: S70 issue: 5 suppl year: 1999 ident: 10.1016/j.foodres.2017.09.037_bb0015 article-title: Physiological and anti-inflammatory roles of dietary fiber and butyrate in intestinal functions publication-title: Journal of Parenteral and Enteral Nutrition doi: 10.1177/014860719902300518 – volume: 124 start-page: 309 issue: 1 year: 2011 ident: 10.1016/j.foodres.2017.09.037_bb0105 article-title: Chemical composition and anti-inflammatory activity of a pectic polysaccharide isolated from sweet pepper using a simulated gastric medium publication-title: Food Chemistry doi: 10.1016/j.foodchem.2010.06.038 |
| SSID | ssj0006579 |
| Score | 2.410837 |
| Snippet | Pectins can modulate the biological responses interacting directly with immune cells. The observed responses can strongly be affected by polysaccharide... |
| SourceID | proquest pubmed crossref elsevier |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 588 |
| SubjectTerms | acid hydrolysis Cytokine secretion esterification Immunomodulatory activity inflammation interleukin-10 interleukin-1beta lipopolysaccharides macrophages molecular weight pectins secretion Structure-function relationship Sweet pepper pectin sweet peppers THP-1 macrophages tumor necrosis factor-alpha viability |
| Title | The influence of sweet pepper pectin structural characteristics on cytokine secretion by THP-1 macrophages |
| URI | https://dx.doi.org/10.1016/j.foodres.2017.09.037 https://www.ncbi.nlm.nih.gov/pubmed/29195989 https://www.proquest.com/docview/1971701964 https://www.proquest.com/docview/2000609161 |
| Volume | 102 |
| WOSCitedRecordID | wos000419418100069&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVESC databaseName: Elsevier SD Freedom Collection Journals 2021 customDbUrl: eissn: 1873-7145 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0006579 issn: 0963-9969 databaseCode: AIEXJ dateStart: 19950101 isFulltext: true titleUrlDefault: https://www.sciencedirect.com providerName: Elsevier |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3Pb9MwFLa6Dgk4IBgMyo_JSNyqjCR14uQ40KYNoWmHAr1FjmOrKa0TLaVs_Fn8hTzHcRINqsGBSxTFTlr5-_L8nuP3PYTeeD6PiRTcCSeEOsQjzGFECIf6bhZIPwuiunzb54_0_DyazeKLweCnzYXZLKlS0dVVXP5XqOEagK1TZ_8B7vahcAHOAXQ4Auxw_Gvgc1t6RPuC1Xf93bkUZSkux3VipRob2dhacoPfkGwGOvDrdfFVu5-VdiprhoCXOj29cLzxiumiX3MwQ1XfsT3R6siNctC8FqFo1xktplkBthxmXL0eWbTr8TkDW5ytmGpZ-iVXKtdBt2yKgs1FvmQ6qwj6vtMlvlhWdN-nVmC0fzRpR1wsx2ebHuHB3mvxlK55WfTXOWDu7PaMCGObIzpxqGfUJ1vj7fo98xuYEoG_TQtmhWJxKGEsYCj0jj5q5G1pvz8AWa5qWvixFt0xxY1u6HHbph2061M4GaLdo7Pj2Yd2_g8DGne5Ym__-Ktag7p5zjaHaFvAUzs-04foQROx4CPDtEdoINQeumsT2qs9dL-nafkYLYB_uOUfLiSu-YcN_7DhH-74h2_wDxcKW_7hln84vcY1_3CPf0_Qp5Pj6ftTpyno4XASkrUjfZeDxyikxwWlAQuFO8kkOPlp6lNooIK5MYklhBjMlbHwIZyWXKbgs3PuZ-FkHw1VocQzhCchh9g-DSDaSEkYMQZhcuayIJaZVtgLR4jYUU14o3avi64sE7utcZE0uCQal8SNE8BlhA7b20oj93LbDZGFLGl8VuOLJsC92259bSFOwKbrV4ApUXyrEi-mdZmEkGzvU6fYgbMfeiP01PCj_ceWWs-3trxA97p37CUaAujiFbrDN-u8ujxAO3QWHTS8_gWS4dpR |
| linkProvider | Elsevier |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+influence+of+sweet+pepper+pectin+structural+characteristics+on+cytokine+secretion+by+THP-1+macrophages&rft.jtitle=Food+research+international&rft.au=do+Nascimento%2C+Georgia+Erdmann&rft.au=Winnischofer%2C+Sheila+Maria+Brochado&rft.au=Ramirez%2C+Marcel+Ivan&rft.au=Iacomini%2C+Marcello&rft.date=2017-12-01&rft.eissn=1873-7145&rft.volume=102&rft.spage=588&rft_id=info:doi/10.1016%2Fj.foodres.2017.09.037&rft_id=info%3Apmid%2F29195989&rft.externalDocID=29195989 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0963-9969&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0963-9969&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0963-9969&client=summon |