A modified k-TSP algorithm and its application in LC–MS-based metabolomics study of hepatocellular carcinoma and chronic liver diseases

•A modified k top scoring pairs (k-TSP) method is suggested to provide an improved classification procedure.•This new k-TSP method was applied to serum metabolomics data derived from LC–MS of liver diseases.•The metabolic feature pairs can be effectively used to differentiate HCC from chronic liver...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Jg. 966; S. 100 - 108
Hauptverfasser:	Lin, Xiaohui, Gao, Jiuchong, Zhou, Lina, Yin, Peiyuan, Xu, Guowang
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Netherlands Elsevier B.V 01.09.2014
Schlagworte:	Algorithms blood serum Carcinoma, Hepatocellular - blood Carcinoma, Hepatocellular - metabolism Chromatography Chromatography, Liquid - methods Classification data collection Diseases Feature selection genomics hepatoma Humans LC–MS liquid chromatography Liver Liver diseases Liver Diseases - blood Liver Diseases - metabolism Liver Neoplasms - blood Liver Neoplasms - metabolism mass spectrometry Mass Spectrometry - methods Metabolome Metabolomics Metabolomics - methods Principal component analysis Top scoring pairs TSP TSP Metabolomics Feature selection Liver diseases Top scoring pairs LC–MS
ISSN:	1570-0232, 1873-376X, 1873-376X
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!