Regional Delivery of Anti-PD-1 Agent for Colorectal Liver Metastases Improves Therapeutic Index and Anti-Tumor Activity

Metastatic liver tumors have presented challenges with the use of checkpoint inhibitors (CPIs), with only limited success. We hypothesize that regional delivery (RD) of CPIs can improve activity in the liver and minimize systemic exposure, thereby reducing immune-related adverse events (irAE). Using...

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Vydané v:	Vaccines (Basel) Ročník 9; číslo 8; s. 807
Hlavní autori:	Chai, Louis F., Hardaway, John C., Heatherton, Kara R., O’Connell, Kyle P., Lopes, Mikayla C., Rabinowitz, Benjamin A., Ghosh, Chandra C., Guha, Prajna, Jaroch, David, Cox, Bryan F., Katz, Steven C.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Basel MDPI AG 21.07.2021 MDPI
Predmet:	Animal models Antibodies Anticancer properties Antitumor agents Apoptosis Biocompatibility Bioluminescence Catheters Colorectal carcinoma Flow cytometry Hepatocytes Immune checkpoint Laboratories Liver Liver cancer liver metastasis Melanoma Metastases Metastasis myeloid-derived suppressor cells PD-1 PD-1 protein PD-L1 PD-L1 protein Portal vein Proteins regional delivery Software Suppressor cells systemic delivery Toxicity Tumor cells Tumors Veins St Louis Missouri United States > US Germany
ISSN:	2076-393X, 2076-393X
On-line prístup:	Získať plný text
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