Regional Delivery of Anti-PD-1 Agent for Colorectal Liver Metastases Improves Therapeutic Index and Anti-Tumor Activity

Metastatic liver tumors have presented challenges with the use of checkpoint inhibitors (CPIs), with only limited success. We hypothesize that regional delivery (RD) of CPIs can improve activity in the liver and minimize systemic exposure, thereby reducing immune-related adverse events (irAE). Using...

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Bibliographic Details
Published in:	Vaccines (Basel) Vol. 9; no. 8; p. 807
Main Authors:	Chai, Louis F., Hardaway, John C., Heatherton, Kara R., O’Connell, Kyle P., Lopes, Mikayla C., Rabinowitz, Benjamin A., Ghosh, Chandra C., Guha, Prajna, Jaroch, David, Cox, Bryan F., Katz, Steven C.
Format:	Journal Article
Language:	English
Published:	Basel MDPI AG 21.07.2021 MDPI
Subjects:	Animal models Antibodies Anticancer properties Antitumor agents Apoptosis Biocompatibility Bioluminescence Catheters Colorectal carcinoma Flow cytometry Hepatocytes Immune checkpoint Laboratories Liver Liver cancer liver metastasis Melanoma Metastases Metastasis myeloid-derived suppressor cells PD-1 PD-1 protein PD-L1 PD-L1 protein Portal vein Proteins regional delivery Software Suppressor cells systemic delivery Toxicity Tumor cells Tumors Veins St Louis Missouri United States > US Germany
ISSN:	2076-393X, 2076-393X
Online Access:	Get full text
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