TNF signaling drives myeloid-derived suppressor cell accumulation

TNF, an inflammatory cytokine that is enriched in the tumor microenvironment, promotes tumor growth and subverts innate immune responses to cancer cells. We previously reported that tumors implanted in TNF receptor-deficient (Tnfr-/-) mice are spontaneously rejected; however, the molecular mechanism...

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Bibliographic Details
Published in:	The Journal of clinical investigation Vol. 122; no. 11; pp. 4094 - 4104
Main Authors:	Zhao, Xueqiang, Rong, Lijie, Zhao, Xiaopu, Li, Xiao, Liu, Xiaoman, Deng, Jingjing, Wu, Hao, Xu, Xia, Erben, Ulrike, Wu, Peihua, Syrbe, Uta, Sieper, Joachim, Qin, Zhihai
Format:	Journal Article
Language:	English
Published:	United States American Society for Clinical Investigation 01.11.2012
Subjects:	Animals Apoptosis Biomedical research Cancer CASP8 and FADD-Like Apoptosis Regulating Protein - biosynthesis CASP8 and FADD-Like Apoptosis Regulating Protein - genetics CASP8 and FADD-Like Apoptosis Regulating Protein - immunology Caspase 8 - genetics Caspase 8 - immunology Caspase 8 - metabolism Cell Line, Tumor Cellular signal transduction Cytotoxicity Dendritic cells Gene expression Genetic aspects Graft Rejection - genetics Graft Rejection - immunology Graft Rejection - metabolism Graft Rejection - pathology Inflammation Mice Mice, Inbred BALB C Mice, Knockout Myeloid Cells - immunology Myeloid Cells - metabolism Myeloid Cells - pathology Neoplasm Transplantation Neoplasms - genetics Neoplasms - immunology Neoplasms - metabolism Neoplasms - pathology Properties Receptors, Tumor Necrosis Factor, Type I - genetics Receptors, Tumor Necrosis Factor, Type I - immunology Receptors, Tumor Necrosis Factor, Type I - metabolism Receptors, Tumor Necrosis Factor, Type II - genetics Receptors, Tumor Necrosis Factor, Type II - immunology Receptors, Tumor Necrosis Factor, Type II - metabolism Signal Transduction - genetics Signal Transduction - immunology T-Lymphocytes - immunology T-Lymphocytes - metabolism T-Lymphocytes - pathology Tumor Escape Tumor necrosis factor Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - immunology Tumor Necrosis Factor-alpha - metabolism Tumors China
ISSN:	0021-9738, 1558-8238, 1558-8238
Online Access:	Get full text
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