Effect of cyclosporine A on the hearing loss in Behçet's disease

Thirty-five patients with Behçet's disease (20 under cyclosporine A [CyA] treatment and 15 under the conventional therapy), 12 patients suffering from endogenous uveitis, and 35 normal subjects were evaluated audiologically before entering the study and were followed up for at least a year. Twe...

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Vydáno v:Annals of otology, rhinology & laryngology Ročník 100; číslo 6; s. 464
Hlavní autoři: Elidan, J, Levi, H, Cohen, E, BenEzra, D
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States 01.06.1991
Témata:
Acoustic Impedance Tests
Adolescent
Adult
Audiometry, Evoked Response
Audiometry, Speech
Behcet Syndrome - complications
Child
Chlorambucil - administration & dosage
Chlorambucil - therapeutic use
Cyclosporins - administration & dosage
Cyclosporins - therapeutic use
Drug Therapy, Combination
Female
Hearing Loss, Sensorineural - drug therapy
Hearing Loss, Sensorineural - epidemiology
Hearing Loss, Sensorineural - etiology
Humans
Incidence
Longitudinal Studies
Male
Middle Aged
Prednisone - administration & dosage
Prednisone - therapeutic use
Reflex, Acoustic
ISSN:0003-4894
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Popis
Shrnutí:Thirty-five patients with Behçet's disease (20 under cyclosporine A [CyA] treatment and 15 under the conventional therapy), 12 patients suffering from endogenous uveitis, and 35 normal subjects were evaluated audiologically before entering the study and were followed up for at least a year. Twenty-eight Behçet patients (80%) showed some degree of hearing loss. The averaged pure tone audiogram of the Behçet group showed statistically significant auditory deficits in comparison with that of the control group. None of either the Behçet group or the uveitis group showed any hearing deterioration during the follow-up period. Five Behçet patients under CyA therapy demonstrated improvement in their hearing. The difference between the two groups of Behçet patients (CyA versus conventional treatment) was found to be statistically significant (p less than .05). Thus, CyA might serve as an important mode of treatment of sensorineural hearing loss on an inflammatory "autoimmune" background.
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ISSN:0003-4894
DOI:10.1177/000348949110000607