Phosphorous Magnetic Resonance Spectroscopy to Detect Regional Differences of Energy and Membrane Metabolism in Naïve Glioblastoma Multiforme
Background: Glioblastoma multiforme (GBM) is a highly malignant primary brain tumor with infiltration of, on conventional imaging, normal-appearing brain parenchyma. Phosphorus magnetic resonance spectroscopy (31P-MRS) enables the investigation of different energy and membrane metabolites. The aim o...
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| Vydáno v: | Cancers Ročník 13; číslo 11; s. 2598 |
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26.05.2021
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| Abstract | Background: Glioblastoma multiforme (GBM) is a highly malignant primary brain tumor with infiltration of, on conventional imaging, normal-appearing brain parenchyma. Phosphorus magnetic resonance spectroscopy (31P-MRS) enables the investigation of different energy and membrane metabolites. The aim of this study is to investigate regional differences of 31P-metabolites in GBM brains. Methods: In this study, we investigated 32 patients (13 female and 19 male; mean age 63 years) with naïve GBM using 31P-MRS and conventional MRI. Contrast-enhancing (CE), T2-hyperintense, adjacent and distant ipsilateral areas of the contralateral brain and the brains of age- and gender-matched healthy volunteers were assessed. Moreover, the 31P-MRS results were correlated with quantitative diffusion parameters. Results: Several metabolite ratios between the energy-dependent metabolites and/or the membrane metabolites differed significantly between the CE areas, the T2-hyperintense areas, the more distant areas, and even the brains of healthy volunteers. pH values and Mg2+ concentrations were highest in visible tumor areas and decreased with distance from them. These results are in accordance with the literature and correlated with quantitative diffusion parameters. Conclusions: This pilot study shows that 31P-MRS is feasible to show regional differences of energy and membrane metabolism in brains with naïve GBM, particularly between the different “normal-appearing” regions and between the contralateral hemisphere and healthy controls. Differences between various genetic mutations or clinical applicability for follow-up monitoring have to be assessed in a larger cohort. |
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| AbstractList | Background: Glioblastoma multiforme (GBM) is a highly malignant primary brain tumor with infiltration of, on conventional imaging, normal-appearing brain parenchyma. Phosphorus magnetic resonance spectroscopy (31P-MRS) enables the investigation of different energy and membrane metabolites. The aim of this study is to investigate regional differences of 31P-metabolites in GBM brains. Methods: In this study, we investigated 32 patients (13 female and 19 male; mean age 63 years) with naïve GBM using 31P-MRS and conventional MRI. Contrast-enhancing (CE), T2-hyperintense, adjacent and distant ipsilateral areas of the contralateral brain and the brains of age- and gender-matched healthy volunteers were assessed. Moreover, the 31P-MRS results were correlated with quantitative diffusion parameters. Results: Several metabolite ratios between the energy-dependent metabolites and/or the membrane metabolites differed significantly between the CE areas, the T2-hyperintense areas, the more distant areas, and even the brains of healthy volunteers. pH values and Mg2+ concentrations were highest in visible tumor areas and decreased with distance from them. These results are in accordance with the literature and correlated with quantitative diffusion parameters. Conclusions: This pilot study shows that 31P-MRS is feasible to show regional differences of energy and membrane metabolism in brains with naïve GBM, particularly between the different "normal-appearing" regions and between the contralateral hemisphere and healthy controls. Differences between various genetic mutations or clinical applicability for follow-up monitoring have to be assessed in a larger cohort.Background: Glioblastoma multiforme (GBM) is a highly malignant primary brain tumor with infiltration of, on conventional imaging, normal-appearing brain parenchyma. Phosphorus magnetic resonance spectroscopy (31P-MRS) enables the investigation of different energy and membrane metabolites. The aim of this study is to investigate regional differences of 31P-metabolites in GBM brains. Methods: In this study, we investigated 32 patients (13 female and 19 male; mean age 63 years) with naïve GBM using 31P-MRS and conventional MRI. Contrast-enhancing (CE), T2-hyperintense, adjacent and distant ipsilateral areas of the contralateral brain and the brains of age- and gender-matched healthy volunteers were assessed. Moreover, the 31P-MRS results were correlated with quantitative diffusion parameters. Results: Several metabolite ratios between the energy-dependent metabolites and/or the membrane metabolites differed significantly between the CE areas, the T2-hyperintense areas, the more distant areas, and even the brains of healthy volunteers. pH values and Mg2+ concentrations were highest in visible tumor areas and decreased with distance from them. These results are in accordance with the literature and correlated with quantitative diffusion parameters. Conclusions: This pilot study shows that 31P-MRS is feasible to show regional differences of energy and membrane metabolism in brains with naïve GBM, particularly between the different "normal-appearing" regions and between the contralateral hemisphere and healthy controls. Differences between various genetic mutations or clinical applicability for follow-up monitoring have to be assessed in a larger cohort. Background: Glioblastoma multiforme (GBM) is a highly malignant primary brain tumor with infiltration of, on conventional imaging, normal-appearing brain parenchyma. Phosphorus magnetic resonance spectroscopy (31P-MRS) enables the investigation of different energy and membrane metabolites. The aim of this study is to investigate regional differences of 31P-metabolites in GBM brains. Methods: In this study, we investigated 32 patients (13 female and 19 male; mean age 63 years) with naïve GBM using 31P-MRS and conventional MRI. Contrast-enhancing (CE), T2-hyperintense, adjacent and distant ipsilateral areas of the contralateral brain and the brains of age- and gender-matched healthy volunteers were assessed. Moreover, the 31P-MRS results were correlated with quantitative diffusion parameters. Results: Several metabolite ratios between the energy-dependent metabolites and/or the membrane metabolites differed significantly between the CE areas, the T2-hyperintense areas, the more distant areas, and even the brains of healthy volunteers. pH values and Mg2+ concentrations were highest in visible tumor areas and decreased with distance from them. These results are in accordance with the literature and correlated with quantitative diffusion parameters. Conclusions: This pilot study shows that 31P-MRS is feasible to show regional differences of energy and membrane metabolism in brains with naïve GBM, particularly between the different “normal-appearing” regions and between the contralateral hemisphere and healthy controls. Differences between various genetic mutations or clinical applicability for follow-up monitoring have to be assessed in a larger cohort. Simple SummaryGlioblastoma multiforme is a highly aggressive brain tumor, tending to infiltrate even larger zones of brain tissue than visible on conventional magnetic resonance imaging. By application of phosphorus magnetic resonance spectroscopy in patients with naïve glioblastoma multiforme, we tried to demonstrate changes in energy and membrane metabolism not only in affected regions but also in distant brain regions, the opposite brain hemisphere, and in comparison to healthy volunteers. We found reduced energetic states and signs of increased cell membrane turnover in regions of visible tumor and differences to and between the “normal-appearing” brains of glioblastoma patients and the brains of healthy volunteers. Our pilot study confirmed the feasibility of the method, so differences between various genetic mutations or clinical applicability for follow-up monitoring can be assessed in larger cohorts.AbstractBackground: Glioblastoma multiforme (GBM) is a highly malignant primary brain tumor with infiltration of, on conventional imaging, normal-appearing brain parenchyma. Phosphorus magnetic resonance spectroscopy (31P-MRS) enables the investigation of different energy and membrane metabolites. The aim of this study is to investigate regional differences of 31P-metabolites in GBM brains. Methods: In this study, we investigated 32 patients (13 female and 19 male; mean age 63 years) with naïve GBM using 31P-MRS and conventional MRI. Contrast-enhancing (CE), T2-hyperintense, adjacent and distant ipsilateral areas of the contralateral brain and the brains of age- and gender-matched healthy volunteers were assessed. Moreover, the 31P-MRS results were correlated with quantitative diffusion parameters. Results: Several metabolite ratios between the energy-dependent metabolites and/or the membrane metabolites differed significantly between the CE areas, the T2-hyperintense areas, the more distant areas, and even the brains of healthy volunteers. pH values and Mg2+ concentrations were highest in visible tumor areas and decreased with distance from them. These results are in accordance with the literature and correlated with quantitative diffusion parameters. Conclusions: This pilot study shows that 31P-MRS is feasible to show regional differences of energy and membrane metabolism in brains with naïve GBM, particularly between the different “normal-appearing” regions and between the contralateral hemisphere and healthy controls. Differences between various genetic mutations or clinical applicability for follow-up monitoring have to be assessed in a larger cohort. |
| Author | Stockhammer, Günther Steiger, Ruth Grams, Astrid Ellen Gizewski, Elke Ruth Rietzler, Andreas Kerschbaumer, Johannes Freyschlag, Christian Franz Walchhofer, Lisa Maria |
| AuthorAffiliation | 4 Department of Neurology, Medical University of Innsbruck, 6020 Innsbruck, Austria; Guenther.Stockhammer@i-med.ac.at 1 Department of Neuroradiology, Medical University of Innsbruck, 6020 Innsbruck, Austria; Lisa-Maria.Walchhofer@tirol-kliniken.at (L.M.W.); Ruth.Steiger@i-med.ac.at (R.S.); Elke.Gizewski@i-med.ac.at (E.R.G.); Astrid.Grams@i-med.ac.at (A.E.G.) 3 Department of Neurosurgery, Medical University of Innsbruck, 6020 Innsbruck, Austria; J.Kerschbaumer@i-med.ac.at (J.K.); Christian.Freyschlag@i-med.ac.at (C.F.F.) 2 Neuroimaging Research Core Facility, Medical University of Innsbruck, 6020 Innsbruck, Austria |
| AuthorAffiliation_xml | – name: 1 Department of Neuroradiology, Medical University of Innsbruck, 6020 Innsbruck, Austria; Lisa-Maria.Walchhofer@tirol-kliniken.at (L.M.W.); Ruth.Steiger@i-med.ac.at (R.S.); Elke.Gizewski@i-med.ac.at (E.R.G.); Astrid.Grams@i-med.ac.at (A.E.G.) – name: 2 Neuroimaging Research Core Facility, Medical University of Innsbruck, 6020 Innsbruck, Austria – name: 4 Department of Neurology, Medical University of Innsbruck, 6020 Innsbruck, Austria; Guenther.Stockhammer@i-med.ac.at – name: 3 Department of Neurosurgery, Medical University of Innsbruck, 6020 Innsbruck, Austria; J.Kerschbaumer@i-med.ac.at (J.K.); Christian.Freyschlag@i-med.ac.at (C.F.F.) |
| Author_xml | – sequence: 1 givenname: Lisa Maria surname: Walchhofer fullname: Walchhofer, Lisa Maria – sequence: 2 givenname: Ruth surname: Steiger fullname: Steiger, Ruth – sequence: 3 givenname: Andreas orcidid: 0000-0002-0808-2667 surname: Rietzler fullname: Rietzler, Andreas – sequence: 4 givenname: Johannes surname: Kerschbaumer fullname: Kerschbaumer, Johannes – sequence: 5 givenname: Christian Franz orcidid: 0000-0002-8228-8217 surname: Freyschlag fullname: Freyschlag, Christian Franz – sequence: 6 givenname: Günther surname: Stockhammer fullname: Stockhammer, Günther – sequence: 7 givenname: Elke Ruth surname: Gizewski fullname: Gizewski, Elke Ruth – sequence: 8 givenname: Astrid Ellen orcidid: 0000-0003-2304-3946 surname: Grams fullname: Grams, Astrid Ellen |
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| CitedBy_id | crossref_primary_10_1007_s11357_024_01403_w crossref_primary_10_3390_cancers14246264 crossref_primary_10_1016_j_neurad_2021_11_006 crossref_primary_10_3390_cancers13143569 crossref_primary_10_1002_mrm_29241 crossref_primary_10_3390_diagnostics14080841 crossref_primary_10_3389_fonc_2024_1462424 crossref_primary_10_1002_nbm_4836 crossref_primary_10_1111_febs_16169 crossref_primary_10_1002_nbm_4845 crossref_primary_10_3389_fneur_2021_735071 crossref_primary_10_1007_s11357_023_01046_3 crossref_primary_10_1007_s10334_021_00997_y crossref_primary_10_3390_cancers14133197 |
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| Snippet | Background: Glioblastoma multiforme (GBM) is a highly malignant primary brain tumor with infiltration of, on conventional imaging, normal-appearing brain... Simple SummaryGlioblastoma multiforme is a highly aggressive brain tumor, tending to infiltrate even larger zones of brain tissue than visible on conventional... |
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| SubjectTerms | Adenosine triphosphate Brain Brain tumors Cell membranes Energy metabolism Feasibility studies Glioblastoma Glioblastoma multiforme Magnesium Magnetic resonance imaging Magnetic resonance spectroscopy Membrane turnover Metabolism Metabolites Metastases Mutation Neuroimaging Parenchyma Patients Phosphorus Spectrum analysis Tumors |
| Title | Phosphorous Magnetic Resonance Spectroscopy to Detect Regional Differences of Energy and Membrane Metabolism in Naïve Glioblastoma Multiforme |
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