Phosphorous Magnetic Resonance Spectroscopy to Detect Regional Differences of Energy and Membrane Metabolism in Naïve Glioblastoma Multiforme

Background: Glioblastoma multiforme (GBM) is a highly malignant primary brain tumor with infiltration of, on conventional imaging, normal-appearing brain parenchyma. Phosphorus magnetic resonance spectroscopy (31P-MRS) enables the investigation of different energy and membrane metabolites. The aim o...

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Veröffentlicht in:Cancers Jg. 13; H. 11; S. 2598
Hauptverfasser: Walchhofer, Lisa Maria, Steiger, Ruth, Rietzler, Andreas, Kerschbaumer, Johannes, Freyschlag, Christian Franz, Stockhammer, Günther, Gizewski, Elke Ruth, Grams, Astrid Ellen
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Basel MDPI AG 26.05.2021
MDPI
Schlagworte:
Adenosine triphosphate
Brain
Brain tumors
Cell membranes
Energy metabolism
Feasibility studies
Glioblastoma
Glioblastoma multiforme
Magnesium
Magnetic resonance imaging
Magnetic resonance spectroscopy
Membrane turnover
Metabolism
Metabolites
Metastases
Mutation
Neuroimaging
Parenchyma
Patients
Phosphorus
Spectrum analysis
Tumors
Germany
ISSN:2072-6694, 2072-6694
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Zusammenfassung:Background: Glioblastoma multiforme (GBM) is a highly malignant primary brain tumor with infiltration of, on conventional imaging, normal-appearing brain parenchyma. Phosphorus magnetic resonance spectroscopy (31P-MRS) enables the investigation of different energy and membrane metabolites. The aim of this study is to investigate regional differences of 31P-metabolites in GBM brains. Methods: In this study, we investigated 32 patients (13 female and 19 male; mean age 63 years) with naïve GBM using 31P-MRS and conventional MRI. Contrast-enhancing (CE), T2-hyperintense, adjacent and distant ipsilateral areas of the contralateral brain and the brains of age- and gender-matched healthy volunteers were assessed. Moreover, the 31P-MRS results were correlated with quantitative diffusion parameters. Results: Several metabolite ratios between the energy-dependent metabolites and/or the membrane metabolites differed significantly between the CE areas, the T2-hyperintense areas, the more distant areas, and even the brains of healthy volunteers. pH values and Mg2+ concentrations were highest in visible tumor areas and decreased with distance from them. These results are in accordance with the literature and correlated with quantitative diffusion parameters. Conclusions: This pilot study shows that 31P-MRS is feasible to show regional differences of energy and membrane metabolism in brains with naïve GBM, particularly between the different “normal-appearing” regions and between the contralateral hemisphere and healthy controls. Differences between various genetic mutations or clinical applicability for follow-up monitoring have to be assessed in a larger cohort.
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ISSN:2072-6694
2072-6694
DOI:10.3390/cancers13112598