Machine Learning Consensus Clustering of Hospitalized Patients with Admission Hyponatremia

Background: The objective of this study was to characterize patients with hyponatremia at hospital admission into clusters using an unsupervised machine learning approach, and to evaluate the short- and long-term mortality risk among these distinct clusters. Methods: We performed consensus cluster a...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Diseases Ročník 9; číslo 3; s. 54
Hlavní autoři: Thongprayoon, Charat, Hansrivijit, Panupong, Mao, Michael A., Vaitla, Pradeep K., Kattah, Andrea G., Pattharanitima, Pattharawin, Vallabhajosyula, Saraschandra, Nissaisorakarn, Voravech, Petnak, Tananchai, Keddis, Mira T., Erickson, Stephen B., Dillon, John J., Garovic, Vesna D., Cheungpasitporn, Wisit
Médium: Journal Article
Jazyk:angličtina
Vydáno: Basel MDPI AG 01.08.2021
MDPI
Témata:
Algorithms
Artificial intelligence
Bicarbonates
Cardiovascular disease
Chronic obstructive pulmonary disease
Cluster analysis
Clustering
Congestive heart failure
Coronary artery
Coronary artery disease
Diabetes
Diabetes mellitus
End-stage renal disease
Hemoglobin
Hospitalization
Hyponatremia
Kidney diseases
Laboratories
Learning algorithms
Lung diseases
Machine learning
Mortality
Obstructive lung disease
Patients
Phenotypes
Potassium
Respiratory diseases
Sodium
Urine
Variance analysis
United States > US
ISSN:2079-9721, 2079-9721
On-line přístup:Získat plný text
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
Popis
Shrnutí:Background: The objective of this study was to characterize patients with hyponatremia at hospital admission into clusters using an unsupervised machine learning approach, and to evaluate the short- and long-term mortality risk among these distinct clusters. Methods: We performed consensus cluster analysis based on demographic information, principal diagnoses, comorbidities, and laboratory data among 11,099 hospitalized adult hyponatremia patients with an admission serum sodium below 135 mEq/L. The standardized mean difference was utilized to identify each cluster’s key features. We assessed the association of each hyponatremia cluster with hospital and one-year mortality using logistic and Cox proportional hazard analysis, respectively. Results: There were three distinct clusters of hyponatremia patients: 2033 (18%) in cluster 1, 3064 (28%) in cluster 2, and 6002 (54%) in cluster 3. Among these three distinct clusters, clusters 3 patients were the youngest, had lowest comorbidity burden, and highest kidney function. Cluster 1 patients were more likely to be admitted for genitourinary disease, and have diabetes and end-stage kidney disease. Cluster 1 patients had the lowest kidney function, serum bicarbonate, and hemoglobin, but highest serum potassium and prevalence of acute kidney injury. In contrast, cluster 2 patients were the oldest and were more likely to be admitted for respiratory disease, have coronary artery disease, congestive heart failure, stroke, and chronic obstructive pulmonary disease. Cluster 2 patients had lowest serum sodium and serum chloride, but highest serum bicarbonate. Cluster 1 patients had the highest hospital mortality and one-year mortality, followed by cluster 2 and cluster 3, respectively. Conclusion: We identified three clinically distinct phenotypes with differing mortality risks in a heterogeneous cohort of hospitalized hyponatremic patients using an unsupervised machine learning approach.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
ISSN:2079-9721
2079-9721
DOI:10.3390/diseases9030054