Enantioselective Artificial Metalloenzymes Based on a Bovine Pancreatic Polypeptide Scaffold

Site creation: Enantioselective artificial metalloenzymes have been created by grafting a new active site onto bovine pancreatic polypeptide through the introduction of an amino acid capable of coordinating a copper(II) ion. This hybrid catalyst gave good enantioselectivities in the Diels-Alder and...

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Veröffentlicht in:Angewandte Chemie (International ed.) Jg. 48; H. 28; S. 5159 - 5162
Hauptverfasser: Coquière, David, Bos, Jeffrey, Beld, Joris, Roelfes, Gerard
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Weinheim Wiley-VCH Verlag 29.06.2009
WILEY‐VCH Verlag
Wiley
Schlagworte:
Amino Acid Sequence
Animals
artificial metalloenzymes
asymmetric catalysis
Catalysis
Cattle
Chemistry
Chemistry, Multidisciplinary
copper
Copper - chemistry
Diels–Alder reactions
Metalloproteins - chemistry
Michael addition
Molecular Sequence Data
Pancreatic Polypeptide - chemistry
Physical Sciences
Science & Technology
Stereoisomerism
Michael addition
OXALOACETATE DECARBOXYLASE
DESIGN
ALPHA,BETA-UNSATURATED 2-ACYL IMIDAZOLES
PROTEIN
asymmetric catalysis
DIRECTED EVOLUTION
BIOTIN-AVIDIN
PEPTIDE
TRIFLATE COMPLEXES
Diels-Alder reactions
HYBRID CATALYSTS
copper
artificial metalloenzymes
ISSN:1433-7851, 1521-3773, 1521-3773
Online-Zugang:Volltext
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Zusammenfassung:Site creation: Enantioselective artificial metalloenzymes have been created by grafting a new active site onto bovine pancreatic polypeptide through the introduction of an amino acid capable of coordinating a copper(II) ion. This hybrid catalyst gave good enantioselectivities in the Diels-Alder and Michael addition reactions in water (see scheme) and displayed a very high substrate selectivity.
Bibliographie:http://dx.doi.org/10.1002/anie.200901134
We wish to thank Dr. W. R. Browne and A. J. Boersma for useful suggestions. Financial support from the NRSC‐Catalysis is gratefully acknowledged.
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ISSN:1433-7851
1521-3773
1521-3773
DOI:10.1002/anie.200901134