Rapid induction of antigen-specific CD4 + T cells is associated with coordinated humoral and cellular immunity to SARS-CoV-2 mRNA vaccination

SARS-CoV-2 mRNA vaccines have shown remarkable clinical efficacy, but questions remain about the nature and kinetics of T cell priming. We performed longitudinal antigen-specific T cell analyses on healthy SARS-CoV-2-naive and recovered individuals prior to and following mRNA prime and boost vaccina...

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Bibliographic Details
Published in:	Immunity (Cambridge, Mass.) Vol. 54; no. 9; p. 2133
Main Authors:	Painter, Mark M, Mathew, Divij, Goel, Rishi R, Apostolidis, Sokratis A, Pattekar, Ajinkya, Kuthuru, Oliva, Baxter, Amy E, Herati, Ramin S, Oldridge, Derek A, Gouma, Sigrid, Hicks, Philip, Dysinger, Sarah, Lundgreen, Kendall A, Kuri-Cervantes, Leticia, Adamski, Sharon, Hicks, Amanda, Korte, Scott, Giles, Josephine R, Weirick, Madison E, McAllister, Christopher M, Dougherty, Jeanette, Long, Sherea, D'Andrea, Kurt, Hamilton, Jacob T, Betts, Michael R, Bates, Paul, Hensley, Scott E, Grifoni, Alba, Weiskopf, Daniela, Sette, Alessandro, Greenplate, Allison R, Wherry, E John
Format:	Journal Article
Language:	English
Published:	United States 14.09.2021
Subjects:	2019-nCoV Vaccine mRNA-1273 Adult Antibodies, Neutralizing - blood Antibodies, Viral - blood Antigens, CD - metabolism Antigens, Differentiation, T-Lymphocyte - metabolism BNT162 Vaccine CD8-Positive T-Lymphocytes - immunology COVID-19 - immunology COVID-19 Vaccines - immunology Female Humans Immunity, Cellular Immunity, Humoral Immunization, Secondary Immunologic Memory Lectins, C-Type - metabolism Lymphocyte Activation Male Middle Aged Peptides - immunology SARS-CoV-2 - physiology Spike Glycoprotein, Coronavirus - immunology Th1 Cells - immunology Vaccination Young Adult SARS-CoV-2 activation induced markers AIM Tfh immunological memory T cells T follicular helper Th1 mRNA vaccine
ISSN:	1097-4180, 1097-4180
Online Access:	Get more information
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