Rapid induction of antigen-specific CD4 + T cells is associated with coordinated humoral and cellular immunity to SARS-CoV-2 mRNA vaccination

SARS-CoV-2 mRNA vaccines have shown remarkable clinical efficacy, but questions remain about the nature and kinetics of T cell priming. We performed longitudinal antigen-specific T cell analyses on healthy SARS-CoV-2-naive and recovered individuals prior to and following mRNA prime and boost vaccina...

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Podrobná bibliografia
Vydané v:	Immunity (Cambridge, Mass.) Ročník 54; číslo 9; s. 2133
Hlavní autori:	Painter, Mark M, Mathew, Divij, Goel, Rishi R, Apostolidis, Sokratis A, Pattekar, Ajinkya, Kuthuru, Oliva, Baxter, Amy E, Herati, Ramin S, Oldridge, Derek A, Gouma, Sigrid, Hicks, Philip, Dysinger, Sarah, Lundgreen, Kendall A, Kuri-Cervantes, Leticia, Adamski, Sharon, Hicks, Amanda, Korte, Scott, Giles, Josephine R, Weirick, Madison E, McAllister, Christopher M, Dougherty, Jeanette, Long, Sherea, D'Andrea, Kurt, Hamilton, Jacob T, Betts, Michael R, Bates, Paul, Hensley, Scott E, Grifoni, Alba, Weiskopf, Daniela, Sette, Alessandro, Greenplate, Allison R, Wherry, E John
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 14.09.2021
Predmet:	2019-nCoV Vaccine mRNA-1273 Adult Antibodies, Neutralizing - blood Antibodies, Viral - blood Antigens, CD - metabolism Antigens, Differentiation, T-Lymphocyte - metabolism BNT162 Vaccine CD8-Positive T-Lymphocytes - immunology COVID-19 - immunology COVID-19 Vaccines - immunology Female Humans Immunity, Cellular Immunity, Humoral Immunization, Secondary Immunologic Memory Lectins, C-Type - metabolism Lymphocyte Activation Male Middle Aged Peptides - immunology SARS-CoV-2 - physiology Spike Glycoprotein, Coronavirus - immunology Th1 Cells - immunology Vaccination Young Adult SARS-CoV-2 activation induced markers AIM Tfh immunological memory T cells T follicular helper Th1 mRNA vaccine
ISSN:	1097-4180, 1097-4180
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Popis
Shrnutí:	SARS-CoV-2 mRNA vaccines have shown remarkable clinical efficacy, but questions remain about the nature and kinetics of T cell priming. We performed longitudinal antigen-specific T cell analyses on healthy SARS-CoV-2-naive and recovered individuals prior to and following mRNA prime and boost vaccination. Vaccination induced rapid antigen-specific CD4 T cell responses in naive subjects after the first dose, whereas CD8 T cell responses developed gradually and were variable in magnitude. Vaccine-induced Th1 and Tfh cell responses following the first dose correlated with post-boost CD8 T cells and neutralizing antibodies, respectively. Integrated analysis revealed coordinated immune responses with distinct trajectories in SARS-CoV-2-naive and recovered individuals. Last, whereas booster vaccination improved T cell responses in SARS-CoV-2-naive subjects, the second dose had little effect in SARS-CoV-2-recovered individuals. These findings highlight the role of rapidly primed CD4 T cells in coordinating responses to the second vaccine dose in SARS-CoV-2-naive individuals.
Bibliografia:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1097-4180 1097-4180
DOI:	10.1016/j.immuni.2021.08.001