The Anticariogenic Effect of Sugar-Free Gum Containing CPP-ACP Nanocomplexes on Approximal Caries Determined Using Digital Bitewing Radiography

This study investigated, using digital bitewing radiography, the progression and regression of approximal caries in adolescent subjects chewing a sugar-free gum containing 54 mg CPP-ACP relative to the identical gum without CPP-ACP. 2,720 subjects from 29 schools were randomly assigned to one of the...

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Bibliographic Details
Published in:Caries research Vol. 42; no. 3; pp. 171 - 184
Main Authors: Morgan, M.V., Adams, G.G., Bailey, D.L., Tsao, C.E., Fischman, S.L., Reynolds, E.C.
Format: Journal Article
Language:English
Published: Basel, Switzerland S. Karger AG 01.01.2008
Subjects:
Adolescent
Cariostatic Agents - therapeutic use
Caseins - therapeutic use
Chewing Gum - analysis
Child
Dental Caries - diagnostic imaging
Dental Caries - prevention & control
Disease Progression
Double-Blind Method
Female
Humans
Logistic Models
Male
Odds Ratio
Original Paper
Radiography, Bitewing
Radiography, Dental, Digital
Sample Size
Sorbitol
Sweetening Agents
Tooth Remineralization - methods
Approximal caries progression
Randomized clinical trial
Sugar-free chewing gum
Digital bitewing radiography
Ordinal categorical data
Casein phosphopeptide-amorphous calcium phosphate nanocomplexes
Enamel remineralization
ISSN:0008-6568, 1421-976X, 1421-976X
Online Access:Get full text
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Summary:This study investigated, using digital bitewing radiography, the progression and regression of approximal caries in adolescent subjects chewing a sugar-free gum containing 54 mg CPP-ACP relative to the identical gum without CPP-ACP. 2,720 subjects from 29 schools were randomly assigned to one of the two gums and were instructed to chew their assigned gum for 3 × 10 min/day, with one session supervised on school days, over the 24-month study period. Standardized digital bitewing radiographs were taken at the baseline and 24-month clinical examinations for each subject. The radiographs, scored by a single examiner, were assessed for approximal surface dental caries at both the enamel and dentine level. Surface level transitions were scored using a transition matrix. Caries progression or regression was analysed using proportional-odds ordered logistic regression modelling of the transition scores at the tooth surface level. There was a statistically significant difference in the frequency distributions of the transition scores between the two gum groups (OR = 0.82, p = 0.03). For subjects chewing the CPP-ACP gum the odds of a surface experiencing caries progression were 18% less than those of a surface experiencing caries progression for subjects chewing the control gum. In conclusion, the 54 mg CPP-ACP sugar-free gum significantly slowed progression and enhanced regression of approximal caries relative to a control sugar-free gum in a 24-month clinical trial.
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ISSN:0008-6568
1421-976X
1421-976X
DOI:10.1159/000128561