Small airways response to naturalistic cat allergen exposure in subjects with asthma
It is currently unclear whether the small airways (diameter <2 μm) contribute significantly to late asthmatic reactions to inhaled allergen. We sought to determine whether naturalistic exposure to cat allergen induced late responses in the small airways as measured by pulmonary function testing a...
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| Veröffentlicht in: | Journal of allergy and clinical immunology Jg. 118; H. 5; S. 1075 - 1081 |
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Mosby, Inc
01.11.2006
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| Abstract | It is currently unclear whether the small airways (diameter <2 μm) contribute significantly to late asthmatic reactions to inhaled allergen.
We sought to determine whether naturalistic exposure to cat allergen induced late responses in the small airways as measured by pulmonary function testing and high-resolution computed tomography (HRCT) of the chest performed at end-expiration.
In a group of 10 subjects with cat-induced asthma, physiologic studies (spirometry and lung volumes, including closing volume) and HRCT were performed before and 6 and 23 hours after a cat room challenge that caused a 20% or greater acute fall in FEV
1.
There was no significant decline in FEV
1 at 6 or 23 hours after cat exposure. Forced expiratory flow at 25% to 75% of forced vital capacity was significantly decreased at 6 hours after the challenge and returned to normal by 23 hours. HRCT image analysis as well as closing volume demonstrated increased air trapping from baseline at both 6 and 23 hours after the challenge. In addition, image analysis demonstrated a significant increase in small airways hyperresponsiveness to methacholine at 23 hours after the challenge. No significant mean changes were noted in lung volumes at either 6 or 23 hours or in PC
20 FEV
1 at 23 hours postchallenge.
These findings demonstrate that naturalistic exposure to cat allergen results in significant small airways obstruction and hyperresponsiveness persisting for at least 23 hours, at which time these changes cannot be detected by conventional physiologic measures.
Physiologically silent distal lung inflammation persists after an antigenic challenge. |
|---|---|
| AbstractList | It is currently unclear whether the small airways (diameter <2 microm) contribute significantly to late asthmatic reactions to inhaled allergen.
We sought to determine whether naturalistic exposure to cat allergen induced late responses in the small airways as measured by pulmonary function testing and high-resolution computed tomography (HRCT) of the chest performed at end-expiration.
In a group of 10 subjects with cat-induced asthma, physiologic studies (spirometry and lung volumes, including closing volume) and HRCT were performed before and 6 and 23 hours after a cat room challenge that caused a 20% or greater acute fall in FEV(1).
There was no significant decline in FEV(1) at 6 or 23 hours after cat exposure. Forced expiratory flow at 25% to 75% of forced vital capacity was significantly decreased at 6 hours after the challenge and returned to normal by 23 hours. HRCT image analysis as well as closing volume demonstrated increased air trapping from baseline at both 6 and 23 hours after the challenge. In addition, image analysis demonstrated a significant increase in small airways hyperresponsiveness to methacholine at 23 hours after the challenge. No significant mean changes were noted in lung volumes at either 6 or 23 hours or in PC(20) FEV(1) at 23 hours postchallenge.
These findings demonstrate that naturalistic exposure to cat allergen results in significant small airways obstruction and hyperresponsiveness persisting for at least 23 hours, at which time these changes cannot be detected by conventional physiologic measures.
Physiologically silent distal lung inflammation persists after an antigenic challenge. It is currently unclear whether the small airways (diameter <2 microm) contribute significantly to late asthmatic reactions to inhaled allergen.BACKGROUNDIt is currently unclear whether the small airways (diameter <2 microm) contribute significantly to late asthmatic reactions to inhaled allergen.We sought to determine whether naturalistic exposure to cat allergen induced late responses in the small airways as measured by pulmonary function testing and high-resolution computed tomography (HRCT) of the chest performed at end-expiration.OBJECTIVESWe sought to determine whether naturalistic exposure to cat allergen induced late responses in the small airways as measured by pulmonary function testing and high-resolution computed tomography (HRCT) of the chest performed at end-expiration.In a group of 10 subjects with cat-induced asthma, physiologic studies (spirometry and lung volumes, including closing volume) and HRCT were performed before and 6 and 23 hours after a cat room challenge that caused a 20% or greater acute fall in FEV(1).METHODSIn a group of 10 subjects with cat-induced asthma, physiologic studies (spirometry and lung volumes, including closing volume) and HRCT were performed before and 6 and 23 hours after a cat room challenge that caused a 20% or greater acute fall in FEV(1).There was no significant decline in FEV(1) at 6 or 23 hours after cat exposure. Forced expiratory flow at 25% to 75% of forced vital capacity was significantly decreased at 6 hours after the challenge and returned to normal by 23 hours. HRCT image analysis as well as closing volume demonstrated increased air trapping from baseline at both 6 and 23 hours after the challenge. In addition, image analysis demonstrated a significant increase in small airways hyperresponsiveness to methacholine at 23 hours after the challenge. No significant mean changes were noted in lung volumes at either 6 or 23 hours or in PC(20) FEV(1) at 23 hours postchallenge.RESULTSThere was no significant decline in FEV(1) at 6 or 23 hours after cat exposure. Forced expiratory flow at 25% to 75% of forced vital capacity was significantly decreased at 6 hours after the challenge and returned to normal by 23 hours. HRCT image analysis as well as closing volume demonstrated increased air trapping from baseline at both 6 and 23 hours after the challenge. In addition, image analysis demonstrated a significant increase in small airways hyperresponsiveness to methacholine at 23 hours after the challenge. No significant mean changes were noted in lung volumes at either 6 or 23 hours or in PC(20) FEV(1) at 23 hours postchallenge.These findings demonstrate that naturalistic exposure to cat allergen results in significant small airways obstruction and hyperresponsiveness persisting for at least 23 hours, at which time these changes cannot be detected by conventional physiologic measures.CONCLUSIONThese findings demonstrate that naturalistic exposure to cat allergen results in significant small airways obstruction and hyperresponsiveness persisting for at least 23 hours, at which time these changes cannot be detected by conventional physiologic measures.Physiologically silent distal lung inflammation persists after an antigenic challenge.CLINICAL IMPLICATIONSPhysiologically silent distal lung inflammation persists after an antigenic challenge. It is currently unclear whether the small airways (diameter <2 μm) contribute significantly to late asthmatic reactions to inhaled allergen. We sought to determine whether naturalistic exposure to cat allergen induced late responses in the small airways as measured by pulmonary function testing and high-resolution computed tomography (HRCT) of the chest performed at end-expiration. In a group of 10 subjects with cat-induced asthma, physiologic studies (spirometry and lung volumes, including closing volume) and HRCT were performed before and 6 and 23 hours after a cat room challenge that caused a 20% or greater acute fall in FEV 1. There was no significant decline in FEV 1 at 6 or 23 hours after cat exposure. Forced expiratory flow at 25% to 75% of forced vital capacity was significantly decreased at 6 hours after the challenge and returned to normal by 23 hours. HRCT image analysis as well as closing volume demonstrated increased air trapping from baseline at both 6 and 23 hours after the challenge. In addition, image analysis demonstrated a significant increase in small airways hyperresponsiveness to methacholine at 23 hours after the challenge. No significant mean changes were noted in lung volumes at either 6 or 23 hours or in PC 20 FEV 1 at 23 hours postchallenge. These findings demonstrate that naturalistic exposure to cat allergen results in significant small airways obstruction and hyperresponsiveness persisting for at least 23 hours, at which time these changes cannot be detected by conventional physiologic measures. Physiologically silent distal lung inflammation persists after an antigenic challenge. Background It is currently unclear whether the small airways (diameter <2 μm) contribute significantly to late asthmatic reactions to inhaled allergen. Objectives We sought to determine whether naturalistic exposure to cat allergen induced late responses in the small airways as measured by pulmonary function testing and high-resolution computed tomography (HRCT) of the chest performed at end-expiration. Methods In a group of 10 subjects with cat-induced asthma, physiologic studies (spirometry and lung volumes, including closing volume) and HRCT were performed before and 6 and 23 hours after a cat room challenge that caused a 20% or greater acute fall in FEV1. Results There was no significant decline in FEV1at 6 or 23 hours after cat exposure. Forced expiratory flow at 25% to 75% of forced vital capacity was significantly decreased at 6 hours after the challenge and returned to normal by 23 hours. HRCT image analysis as well as closing volume demonstrated increased air trapping from baseline at both 6 and 23 hours after the challenge. In addition, image analysis demonstrated a significant increase in small airways hyperresponsiveness to methacholine at 23 hours after the challenge. No significant mean changes were noted in lung volumes at either 6 or 23 hours or in PC20FEV1at 23 hours postchallenge. Conclusion These findings demonstrate that naturalistic exposure to cat allergen results in significant small airways obstruction and hyperresponsiveness persisting for at least 23 hours, at which time these changes cannot be detected by conventional physiologic measures. Clinical implications Physiologically silent distal lung inflammation persists after an antigenic challenge. |
| Author | Corren, Jonathan Kleerup, Eric C. Kim, Hyun J. Zeidler, Michelle R. Goldin, Jonathan G. Silverman, Jeffrey M. Gjertson, David W. Kennedy, Nola J. Tashkin, Donald P. Truong, Dao A. Newman, Kenneth B. |
| Author_xml | – sequence: 1 givenname: Michelle R. surname: Zeidler fullname: Zeidler, Michelle R. organization: From the Divisions of Pulmonary, Critical Care Medicine and Hospitalists – sequence: 2 givenname: Jonathan G. surname: Goldin fullname: Goldin, Jonathan G. organization: Thoracic Radiology, David Geffen School of Medicine – sequence: 3 givenname: Eric C. surname: Kleerup fullname: Kleerup, Eric C. organization: From the Divisions of Pulmonary, Critical Care Medicine and Hospitalists – sequence: 4 givenname: Hyun J. surname: Kim fullname: Kim, Hyun J. organization: Thoracic Radiology, David Geffen School of Medicine – sequence: 5 givenname: Dao A. surname: Truong fullname: Truong, Dao A. organization: Thoracic Radiology, David Geffen School of Medicine – sequence: 6 givenname: David W. surname: Gjertson fullname: Gjertson, David W. organization: Thoracic Radiology, David Geffen School of Medicine – sequence: 7 givenname: Nola J. surname: Kennedy fullname: Kennedy, Nola J. organization: School of Public Health, University of California, Los Angeles – sequence: 8 givenname: Kenneth B. surname: Newman fullname: Newman, Kenneth B. organization: Forest Laboratories, New York – sequence: 9 givenname: Donald P. surname: Tashkin fullname: Tashkin, Donald P. organization: From the Divisions of Pulmonary, Critical Care Medicine and Hospitalists – sequence: 10 givenname: Jeffrey M. surname: Silverman fullname: Silverman, Jeffrey M. organization: Keck School of Medicine at the University of Southern California and Landmark Imaging – sequence: 11 givenname: Jonathan surname: Corren fullname: Corren, Jonathan email: jcorren@ucla.edu organization: Division of Clinical Immunology and Allergy, David Geffen School of Medicine and Allergy Research Foundation |
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| Cites_doi | 10.1378/chest.73.5.568 10.1088/0031-9155/48/16/306 10.1164/ajrccm.163.1.16310b 10.1046/j.1365-2222.2001.01048.x 10.1164/ajrccm.159.1.9804033 10.1164/ajrccm/141.2.361 10.1148/radiology.208.2.9680554 10.1067/mai.2003.1612 10.1164/ajrccm.152.3.7663792 10.1183/09031936.99.14614039 10.1183/09031936.06.00005605 10.1016/S0300-483X(00)00292-4 10.1164/ajrccm.154.5.8912772 10.1016/j.jaci.2005.07.029 10.1378/chest.63.4_Supplement.29S 10.1067/mpd.2002.125006 10.1164/ajrccm.161.6.9906075 10.1164/ajrccm.159.1.9712108 10.1136/thx.53.1.33 10.1164/ajrccm/148.5.1220 10.1136/thx.51.12.1185 10.1111/j.1398-9995.1990.tb00495.x 10.1111/j.1398-9995.1991.tb04220.x 10.1016/0091-6749(85)90678-5 10.1016/S0091-6749(97)70193-3 10.1016/S1081-1206(10)62228-4 10.1016/S0091-6749(99)70043-6 |
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| Keywords | BDP-CFC RV BDP-HFA TLC image analysis HU Asthma computer-assisted LAC FVC CV CRC tomography FRC Fel d 1 protein x-ray computed HRCT bronchial hyperreactivity CV/VC FEF 25-75 MCT Fel d I protein Allergy Hyperreactivity X ray Respiratory system Respiratory tract Immunology Tomography Bronchus disease Obstructive pulmonary disease Computer aid Human Fissipedia Immunopathology Lung disease Carnivora Radiodiagnosis Respiratory disease Exploration Exposure Radiography Vertebrata Image analysis Mammalia Cat Allergen |
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| References | Hamid, Song, Kotsimbos, Minshall, Bai, Hegele (bib4) 1997; 100 Popa (bib21) 2001; 163 Goldman, Becklake (bib34) 1959; 79 Buist, Ross (bib35) 1973; 63 Machado, Stalenheim (bib9) 1990; 45 Sherter, Connolly, Schilder (bib12) 1978; 73 Hauber, Gotfried, Newman, Danda, Servi, Christodoulopoulos (bib7) 2003; 112 American Thoracic Society (bib19) 1995; 152 Hankinson, Odencrantz, Fedan (bib33) 1999; 159 Goldin, McNitt-Gray, Sorenson, Johnson, Dauphinee, Kleerup (bib14) 1998; 208 Peebles, Hamilton, Lichtenstein, Schlosberg, Liu, Proud (bib11) 2001; 31 Goldin, Tashkin, Kleerup, Greaser, Haywood, Sayre (bib24) 1999; 104 Kuwano, Bosken, Pare, Bai, Wiggs, Hogg (bib3) 1993; 148 Martin, Macklem (bib20) 1973 McFadden, Holmes, Kiker (bib13) 1975; 111 Carroll, James (bib31) 1993; 147 Kraft, Djukanovic, Wilson, Holgate, Martin (bib32) 1996; 154 Kraft (bib2) 1999; 14 Bergeron, Hauber, Gotfried, Newman, Dhanda, Servi (bib6) 2005; 116 Evans, Coulby, O'Connor (bib8) 1996; 51 Rasmussen (bib10) 1991; 46 Diaz-Sanchez, Corren, Nicodemus, Philip (bib30) 1998; 101 Kraft, Martin, Wilson, Djukanovic, Holgate (bib5) 1999; 159 in 't Veen JC, Beekman AJ, Bel EH, Sterk PJ. Recurrent exacerbations in severe asthma are associated with enhanced airway closure during stable episodes. Am J Respir Crit Care Med 2000;161:1902-6. Jarry, DeMarco, Beifuss, Cagnon, McNitt-Gray (bib16) 2003; 48 Custovic, Simpson, Pahdi, Green, Chapman, Woodcock (bib28) 1998; 53 ImPact CT dosimetry spreadsheet version 0.99u. London: Imaging Performance Assessment of CT scanners (ImPACT), St George Hospital. 2003. Available at Tashkin (bib1) 2002; 23 Accessed June 16, 2004. Pifferi, Caramella, Ragazzo, Pietrobelli, Boner (bib23) 2002; 141 Zeidler, Goldin, Kleerup, Truong, Simmons, Kim (bib15) 2006; 27 Swanson, Agarwal, Reed (bib29) 1985; 76 American Association for Respiratory Care (bib18) 1994; 39 Luczynska, Li, Chapman, Platts-Mills (bib27) 1990; 141 Corren, Spector, Fuller, Minkwitz, Mezzanotte (bib22) 2001; 87 Ormstad (bib26) 2000; 152 Ormstad (10.1016/j.jaci.2006.06.042_bib26) 2000; 152 McFadden (10.1016/j.jaci.2006.06.042_bib13) 1975; 111 Goldin (10.1016/j.jaci.2006.06.042_bib24) 1999; 104 Martin (10.1016/j.jaci.2006.06.042_bib20) 1973 10.1016/j.jaci.2006.06.042_bib17 Kraft (10.1016/j.jaci.2006.06.042_bib32) 1996; 154 Tashkin (10.1016/j.jaci.2006.06.042_bib1) 2002; 23 Buist (10.1016/j.jaci.2006.06.042_bib35) 1973; 63 Kraft (10.1016/j.jaci.2006.06.042_bib5) 1999; 159 Popa (10.1016/j.jaci.2006.06.042_bib21) 2001; 163 Carroll (10.1016/j.jaci.2006.06.042_bib31) 1993; 147 Kraft (10.1016/j.jaci.2006.06.042_bib2) 1999; 14 10.1016/j.jaci.2006.06.042_bib25 Diaz-Sanchez (10.1016/j.jaci.2006.06.042_bib30) 1998; 101 American Thoracic Society (10.1016/j.jaci.2006.06.042_bib19) 1995; 152 Hauber (10.1016/j.jaci.2006.06.042_bib7) 2003; 112 Bergeron (10.1016/j.jaci.2006.06.042_bib6) 2005; 116 Peebles (10.1016/j.jaci.2006.06.042_bib11) 2001; 31 Goldman (10.1016/j.jaci.2006.06.042_bib34) 1959; 79 Goldin (10.1016/j.jaci.2006.06.042_bib14) 1998; 208 Corren (10.1016/j.jaci.2006.06.042_bib22) 2001; 87 Evans (10.1016/j.jaci.2006.06.042_bib8) 1996; 51 Sherter (10.1016/j.jaci.2006.06.042_bib12) 1978; 73 Hamid (10.1016/j.jaci.2006.06.042_bib4) 1997; 100 Pifferi (10.1016/j.jaci.2006.06.042_bib23) 2002; 141 Custovic (10.1016/j.jaci.2006.06.042_bib28) 1998; 53 Hankinson (10.1016/j.jaci.2006.06.042_bib33) 1999; 159 Rasmussen (10.1016/j.jaci.2006.06.042_bib10) 1991; 46 Kuwano (10.1016/j.jaci.2006.06.042_bib3) 1993; 148 Jarry (10.1016/j.jaci.2006.06.042_bib16) 2003; 48 Zeidler (10.1016/j.jaci.2006.06.042_bib15) 2006; 27 Machado (10.1016/j.jaci.2006.06.042_bib9) 1990; 45 American Association for Respiratory Care (10.1016/j.jaci.2006.06.042_bib18) 1994; 39 Luczynska (10.1016/j.jaci.2006.06.042_bib27) 1990; 141 Swanson (10.1016/j.jaci.2006.06.042_bib29) 1985; 76 |
| References_xml | – volume: 45 start-page: 268 year: 1990 end-page: 274 ident: bib9 article-title: Factors influencing the occurrence of late bronchial reactions after allergen challenge publication-title: Allergy – volume: 31 start-page: 239 year: 2001 end-page: 248 ident: bib11 article-title: Antigen-specific IgE and IgA antibodies in bronchoalveolar lavage fluid are associated with stronger antigen-induced late phase reactions publication-title: Clin Exp Allergy – volume: 48 start-page: 2645 year: 2003 end-page: 2663 ident: bib16 article-title: A Monte Carlo-based method to estimate radiation dose from spiral CT: from phantom testing to patient-specific models publication-title: Phys Med Biol – volume: 141 start-page: 361 year: 1990 end-page: 367 ident: bib27 article-title: Airborne concentrations and particle size distribution of allergen derived from domestic cats (Felis domesticus): measurements using cascade impactor, liquid impinger, and a two-site monoclonal antibody assay for Fel d I publication-title: Am Rev Respir Dis – volume: 51 start-page: 1185 year: 1996 end-page: 1191 ident: bib8 article-title: Effect of allergen challenge on airway responsiveness to histamine and sodium metabisulphite in mild asthma publication-title: Thorax – volume: 27 start-page: 307 year: 2006 end-page: 315 ident: bib15 article-title: Montelukast improves regional air-trapping due to small airways obstruction in asthma publication-title: Eur Respir J – volume: 152 start-page: 1107 year: 1995 end-page: 1136 ident: bib19 article-title: Standardization of spirometry: 1994 update publication-title: Am J Respir Crit Care Med – volume: 76 start-page: 724 year: 1985 end-page: 729 ident: bib29 article-title: An immunochemical approach to indoor aeroallergen quantitation with a new volumetric air sampler: studies with mite, roach, cat, mouse, and guinea pig antigens publication-title: J Allergy Clin Immunol – volume: 159 start-page: 179 year: 1999 end-page: 187 ident: bib33 article-title: Spirometric reference values from a sample of the general U.S. population publication-title: Am J Respir Crit Care Med – volume: 159 start-page: 228 year: 1999 end-page: 234 ident: bib5 article-title: Lymphocyte and eosinophil influx into alveolar tissue in nocturnal asthma publication-title: Am J Respir Crit Care Med – volume: 104 start-page: S258 year: 1999 end-page: S267 ident: bib24 article-title: Comparative effects of hydrofluoroalkane and chlorofluorocarbon beclomethasone dipropionate inhalation on small airways: assessment with functional helical thin-section computed tomography publication-title: J Allergy Clin Immunol – volume: 63 start-page: 29S year: 1973 end-page: 30S ident: bib35 article-title: Closing volume as a simple, sensitive test for the detection of peripheral airway disease publication-title: Chest – reference: ImPact CT dosimetry spreadsheet version 0.99u. London: Imaging Performance Assessment of CT scanners (ImPACT), St George Hospital. 2003. Available at: – volume: 39 start-page: 1184 year: 1994 end-page: 1190 ident: bib18 article-title: AARC clinical practice guideline: body plethysmography publication-title: Respir Care – volume: 53 start-page: 33 year: 1998 end-page: 38 ident: bib28 article-title: Distribution, aerodynamic characteristics, and removal of the major cat allergen Fel d 1 in British homes publication-title: Thorax – volume: 116 start-page: 983 year: 2005 end-page: 989 ident: bib6 article-title: Evidence of remodeling in peripheral airways of patients with mild to moderate asthma: effect of hydrofluoroalkane-flunisolide publication-title: J Allergy Clin Immunol – volume: 154 start-page: 1505 year: 1996 end-page: 1510 ident: bib32 article-title: Alveolar tissue inflammation in asthma publication-title: Am J Respir Crit Care Med – volume: 87 start-page: 211 year: 2001 end-page: 217 ident: bib22 article-title: Effects of zafirlukast upon clinical, physiologic, and inflammatory responses to natural cat allergen exposure publication-title: Ann Allergy Asthma Immunol – volume: 147 start-page: 29S year: 1993 end-page: 30S ident: bib31 article-title: The distribution of inflammatory cells in the bronchial tree in fatal and nonfatal asthma publication-title: Am Rev Respir Dis – volume: 100 start-page: 44 year: 1997 end-page: 51 ident: bib4 article-title: Inflammation of small airways in asthma publication-title: J Allergy Clin Immunol – year: 1973 ident: bib20 article-title: Suggested standardization procedures for closing volume determination (nitrogen method) – volume: 208 start-page: 321 year: 1998 end-page: 329 ident: bib14 article-title: Airway hyperreactivity: assessment with helical thin-section CT publication-title: Radiology – volume: 79 start-page: 457 year: 1959 end-page: 467 ident: bib34 article-title: Respiratory function tests: normal values at median altitudes and the prediction of normal results publication-title: Am Rev Tuberc – volume: 152 start-page: 53 year: 2000 end-page: 68 ident: bib26 article-title: Suspended particulate matter in indoor air: adjuvants and allergen carriers publication-title: Toxicology – volume: 111 start-page: 135 year: 1975 end-page: 140 ident: bib13 article-title: Variability of closing volume measurements in normal man publication-title: Am Rev Respir Dis – volume: 112 start-page: 58 year: 2003 end-page: 63 ident: bib7 article-title: Effect of HFA-flunisolide on peripheral lung inflammation in asthma publication-title: J Allergy Clin Immunol – volume: 163 start-page: 292 year: 2001 end-page: 293 ident: bib21 article-title: ATS guidelines for methacholine and exercise challenge testing publication-title: Am J Respir Crit Care Med – volume: 101 start-page: A210 year: 1998 ident: bib30 article-title: Cat room challenge and markers of upper and lower airways inflammation publication-title: J Allergy Clin Immunol – volume: 46 start-page: 419 year: 1991 end-page: 426 ident: bib10 article-title: Late airway response increases at repeat allergen challenge publication-title: Allergy – volume: 73 start-page: 568 year: 1978 end-page: 571 ident: bib12 article-title: The significance of volume-adjusting the maximal midexpiratory flow in assessing the response to a bronchodilator drug publication-title: Chest – reference: in 't Veen JC, Beekman AJ, Bel EH, Sterk PJ. Recurrent exacerbations in severe asthma are associated with enhanced airway closure during stable episodes. Am J Respir Crit Care Med 2000;161:1902-6. – volume: 141 start-page: 104 year: 2002 end-page: 108 ident: bib23 article-title: Low-density areas on high-resolution computed tomograms in chronic pediatric asthma publication-title: J Pediatr – volume: 148 start-page: 1220 year: 1993 end-page: 1225 ident: bib3 article-title: Small airways dimensions in asthma and in chronic obstructive pulmonary disease publication-title: Am Rev Respir Dis – volume: 23 start-page: 233 year: 2002 end-page: 242 ident: bib1 article-title: The role of small airway inflammation in asthma publication-title: Allergy Asthma Proc – volume: 14 start-page: 1403 year: 1999 end-page: 1417 ident: bib2 article-title: The distal airways: are they important in asthma? publication-title: Eur Respir J – reference: . Accessed June 16, 2004. – volume: 73 start-page: 568 year: 1978 ident: 10.1016/j.jaci.2006.06.042_bib12 article-title: The significance of volume-adjusting the maximal midexpiratory flow in assessing the response to a bronchodilator drug publication-title: Chest doi: 10.1378/chest.73.5.568 – volume: 48 start-page: 2645 year: 2003 ident: 10.1016/j.jaci.2006.06.042_bib16 article-title: A Monte Carlo-based method to estimate radiation dose from spiral CT: from phantom testing to patient-specific models publication-title: Phys Med Biol doi: 10.1088/0031-9155/48/16/306 – volume: 163 start-page: 292 year: 2001 ident: 10.1016/j.jaci.2006.06.042_bib21 article-title: ATS guidelines for methacholine and exercise challenge testing publication-title: Am J Respir Crit Care Med doi: 10.1164/ajrccm.163.1.16310b – volume: 31 start-page: 239 year: 2001 ident: 10.1016/j.jaci.2006.06.042_bib11 article-title: Antigen-specific IgE and IgA antibodies in bronchoalveolar lavage fluid are associated with stronger antigen-induced late phase reactions publication-title: Clin Exp Allergy doi: 10.1046/j.1365-2222.2001.01048.x – volume: 159 start-page: 228 year: 1999 ident: 10.1016/j.jaci.2006.06.042_bib5 article-title: Lymphocyte and eosinophil influx into alveolar tissue in nocturnal asthma publication-title: Am J Respir Crit Care Med doi: 10.1164/ajrccm.159.1.9804033 – volume: 141 start-page: 361 year: 1990 ident: 10.1016/j.jaci.2006.06.042_bib27 article-title: Airborne concentrations and particle size distribution of allergen derived from domestic cats (Felis domesticus): measurements using cascade impactor, liquid impinger, and a two-site monoclonal antibody assay for Fel d I publication-title: Am Rev Respir Dis doi: 10.1164/ajrccm/141.2.361 – volume: 208 start-page: 321 year: 1998 ident: 10.1016/j.jaci.2006.06.042_bib14 article-title: Airway hyperreactivity: assessment with helical thin-section CT publication-title: Radiology doi: 10.1148/radiology.208.2.9680554 – volume: 23 start-page: 233 year: 2002 ident: 10.1016/j.jaci.2006.06.042_bib1 article-title: The role of small airway inflammation in asthma publication-title: Allergy Asthma Proc – volume: 112 start-page: 58 year: 2003 ident: 10.1016/j.jaci.2006.06.042_bib7 article-title: Effect of HFA-flunisolide on peripheral lung inflammation in asthma publication-title: J Allergy Clin Immunol doi: 10.1067/mai.2003.1612 – volume: 101 start-page: A210 year: 1998 ident: 10.1016/j.jaci.2006.06.042_bib30 article-title: Cat room challenge and markers of upper and lower airways inflammation publication-title: J Allergy Clin Immunol – volume: 152 start-page: 1107 year: 1995 ident: 10.1016/j.jaci.2006.06.042_bib19 article-title: Standardization of spirometry: 1994 update publication-title: Am J Respir Crit Care Med doi: 10.1164/ajrccm.152.3.7663792 – ident: 10.1016/j.jaci.2006.06.042_bib17 – volume: 14 start-page: 1403 year: 1999 ident: 10.1016/j.jaci.2006.06.042_bib2 article-title: The distal airways: are they important in asthma? publication-title: Eur Respir J doi: 10.1183/09031936.99.14614039 – volume: 27 start-page: 307 year: 2006 ident: 10.1016/j.jaci.2006.06.042_bib15 article-title: Montelukast improves regional air-trapping due to small airways obstruction in asthma publication-title: Eur Respir J doi: 10.1183/09031936.06.00005605 – volume: 147 start-page: 29S year: 1993 ident: 10.1016/j.jaci.2006.06.042_bib31 article-title: The distribution of inflammatory cells in the bronchial tree in fatal and nonfatal asthma publication-title: Am Rev Respir Dis – volume: 152 start-page: 53 year: 2000 ident: 10.1016/j.jaci.2006.06.042_bib26 article-title: Suspended particulate matter in indoor air: adjuvants and allergen carriers publication-title: Toxicology doi: 10.1016/S0300-483X(00)00292-4 – volume: 154 start-page: 1505 year: 1996 ident: 10.1016/j.jaci.2006.06.042_bib32 article-title: Alveolar tissue inflammation in asthma publication-title: Am J Respir Crit Care Med doi: 10.1164/ajrccm.154.5.8912772 – volume: 116 start-page: 983 year: 2005 ident: 10.1016/j.jaci.2006.06.042_bib6 article-title: Evidence of remodeling in peripheral airways of patients with mild to moderate asthma: effect of hydrofluoroalkane-flunisolide publication-title: J Allergy Clin Immunol doi: 10.1016/j.jaci.2005.07.029 – volume: 63 start-page: 29S issue: suppl year: 1973 ident: 10.1016/j.jaci.2006.06.042_bib35 article-title: Closing volume as a simple, sensitive test for the detection of peripheral airway disease publication-title: Chest doi: 10.1378/chest.63.4_Supplement.29S – volume: 141 start-page: 104 year: 2002 ident: 10.1016/j.jaci.2006.06.042_bib23 article-title: Low-density areas on high-resolution computed tomograms in chronic pediatric asthma publication-title: J Pediatr doi: 10.1067/mpd.2002.125006 – volume: 79 start-page: 457 year: 1959 ident: 10.1016/j.jaci.2006.06.042_bib34 article-title: Respiratory function tests: normal values at median altitudes and the prediction of normal results publication-title: Am Rev Tuberc – ident: 10.1016/j.jaci.2006.06.042_bib25 doi: 10.1164/ajrccm.161.6.9906075 – volume: 159 start-page: 179 year: 1999 ident: 10.1016/j.jaci.2006.06.042_bib33 article-title: Spirometric reference values from a sample of the general U.S. population publication-title: Am J Respir Crit Care Med doi: 10.1164/ajrccm.159.1.9712108 – volume: 53 start-page: 33 year: 1998 ident: 10.1016/j.jaci.2006.06.042_bib28 article-title: Distribution, aerodynamic characteristics, and removal of the major cat allergen Fel d 1 in British homes publication-title: Thorax doi: 10.1136/thx.53.1.33 – volume: 148 start-page: 1220 year: 1993 ident: 10.1016/j.jaci.2006.06.042_bib3 article-title: Small airways dimensions in asthma and in chronic obstructive pulmonary disease publication-title: Am Rev Respir Dis doi: 10.1164/ajrccm/148.5.1220 – volume: 51 start-page: 1185 year: 1996 ident: 10.1016/j.jaci.2006.06.042_bib8 article-title: Effect of allergen challenge on airway responsiveness to histamine and sodium metabisulphite in mild asthma publication-title: Thorax doi: 10.1136/thx.51.12.1185 – volume: 45 start-page: 268 year: 1990 ident: 10.1016/j.jaci.2006.06.042_bib9 article-title: Factors influencing the occurrence of late bronchial reactions after allergen challenge publication-title: Allergy doi: 10.1111/j.1398-9995.1990.tb00495.x – volume: 46 start-page: 419 year: 1991 ident: 10.1016/j.jaci.2006.06.042_bib10 article-title: Late airway response increases at repeat allergen challenge publication-title: Allergy doi: 10.1111/j.1398-9995.1991.tb04220.x – volume: 76 start-page: 724 year: 1985 ident: 10.1016/j.jaci.2006.06.042_bib29 article-title: An immunochemical approach to indoor aeroallergen quantitation with a new volumetric air sampler: studies with mite, roach, cat, mouse, and guinea pig antigens publication-title: J Allergy Clin Immunol doi: 10.1016/0091-6749(85)90678-5 – volume: 39 start-page: 1184 year: 1994 ident: 10.1016/j.jaci.2006.06.042_bib18 article-title: AARC clinical practice guideline: body plethysmography publication-title: Respir Care – volume: 100 start-page: 44 year: 1997 ident: 10.1016/j.jaci.2006.06.042_bib4 article-title: Inflammation of small airways in asthma publication-title: J Allergy Clin Immunol doi: 10.1016/S0091-6749(97)70193-3 – volume: 111 start-page: 135 year: 1975 ident: 10.1016/j.jaci.2006.06.042_bib13 article-title: Variability of closing volume measurements in normal man publication-title: Am Rev Respir Dis – volume: 87 start-page: 211 year: 2001 ident: 10.1016/j.jaci.2006.06.042_bib22 article-title: Effects of zafirlukast upon clinical, physiologic, and inflammatory responses to natural cat allergen exposure publication-title: Ann Allergy Asthma Immunol doi: 10.1016/S1081-1206(10)62228-4 – volume: 104 start-page: S258 year: 1999 ident: 10.1016/j.jaci.2006.06.042_bib24 article-title: Comparative effects of hydrofluoroalkane and chlorofluorocarbon beclomethasone dipropionate inhalation on small airways: assessment with functional helical thin-section computed tomography publication-title: J Allergy Clin Immunol doi: 10.1016/S0091-6749(99)70043-6 – year: 1973 ident: 10.1016/j.jaci.2006.06.042_bib20 |
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| Snippet | It is currently unclear whether the small airways (diameter <2 μm) contribute significantly to late asthmatic reactions to inhaled allergen.
We sought to... It is currently unclear whether the small airways (diameter <2 microm) contribute significantly to late asthmatic reactions to inhaled allergen. We sought to... Background It is currently unclear whether the small airways (diameter <2 μm) contribute significantly to late asthmatic reactions to inhaled allergen.... It is currently unclear whether the small airways (diameter <2 microm) contribute significantly to late asthmatic reactions to inhaled allergen.BACKGROUNDIt is... |
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| SubjectTerms | Adult Allergens - administration & dosage Allergens - immunology Animals Asthma Asthma - immunology Asthma - physiopathology Biological and medical sciences bronchial hyperreactivity Bronchial Provocation Tests Bronchoscopy Bronchospirometry Cats computer-assisted Fel d 1 protein Female Fundamental and applied biological sciences. Psychology Fundamental immunology Glycoproteins - administration & dosage Glycoproteins - immunology Humans image analysis Immunopathology Male Medical imaging Medical sciences Plethysmography Studies Tomography Tomography, X-Ray Computed Total Lung Capacity x-ray computed |
| Title | Small airways response to naturalistic cat allergen exposure in subjects with asthma |
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