Fluoride and Casein Phosphopeptide-Amorphous Calcium Phosphate

Casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) slows the progression of caries and remineralizes enamel subsurface lesions. The aim of this study was to determine the ability of CPP-ACP to increase the incorporation of fluoride into plaque and to promote enamel remineralization in situ....

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Published in:	Journal of dental research Vol. 87; no. 4; pp. 344 - 348
Main Authors:	Reynolds, E.C., Cai, F., Cochrane, N.J., Shen, P., Walker, G.D., Morgan, M.V., Reynolds, C.
Format:	Journal Article
Language:	English
Published:	United States SAGE Publications 01.04.2008 SAGE PUBLICATIONS, INC
Subjects:	acid resistance Adult Apatites - analysis Cariostatic Agents - administration & dosage Cariostatic Agents - pharmacokinetics Cariostatic Agents - therapeutic use casein phosphopeptide-amorphous calcium phosphate Caseins - administration & dosage Caseins - therapeutic use Chemistry, Pharmaceutical Cross-Over Studies Dental Enamel - metabolism Dental Plaque - metabolism Dentifrices - therapeutic use Double-Blind Method Drug Combinations Electron Probe Microanalysis enamel subsurface lesion remineralization Female fluoride Fluorides - administration & dosage Fluorides - pharmacokinetics Fluorides - therapeutic use Humans Male Middle Aged Mouthwashes - therapeutic use Placebos plaque uptake Sodium Fluoride - administration & dosage Sodium Fluoride - therapeutic use Tooth Remineralization - methods fluoride casein phosphopeptide-amorphous calcium phosphate acid resistance plaque uptake enamel subsurface lesion remineralization
ISSN:	0022-0345, 1544-0591
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Abstract	Casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) slows the progression of caries and remineralizes enamel subsurface lesions. The aim of this study was to determine the ability of CPP-ACP to increase the incorporation of fluoride into plaque and to promote enamel remineralization in situ. Randomized, double-blind, cross-over studies involved mouthrinses and dentifrices containing CPP-ACP and fluoride. The mouthrinses were used for 60 sec, three times/day for 5 days, and supragingival plaque was collected and analyzed for F. The dentifrices were rinsed as a water slurry for 60 sec four times/day for 14 days in an in situ model. The addition of 2% CPP-ACP to the 450-ppm-F mouthrinse significantly increased the incorporation of fluoride into plaque. The dentifrice containing 2% CPP-ACP produced a level of remineralization similar to that achieved with a dentifrice containing 2800 ppm F. The dentifrice containing 2% CPP-ACP plus 1100 ppm F was superior to all other formulations.
AbstractList	Casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) slows the progression of caries and remineralizes enamel subsurface lesions. The aim of this study was to determine the ability of CPP-ACP to increase the incorporation of fluoride into plaque and to promote enamel remineralization in situ. Randomized, double-blind, cross-over studies involved mouthrinses and dentifrices containing CPP-ACP and fluoride. The mouthrinses were used for 60 sec, three times/day for 5 days, and supragingival plaque was collected and analyzed for F. The dentifrices were rinsed as a water slurry for 60 sec four times/day for 14 days in an in situ model. The addition of 2% CPP-ACP to the 450-ppm-F mouthrinse significantly increased the incorporation of fluoride into plaque. The dentifrice containing 2% CPP-ACP produced a level of remineralization similar to that achieved with a dentifrice containing 2800 ppm F. The dentifrice containing 2% CPP-ACP plus 1100 ppm F was superior to all other formulations. Casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) slows the progression of caries and remineralizes enamel subsurface lesions. The aim of this study was to determine the ability of CPP-ACP to increase the incorporation of fluoride into plaque and to promote enamel remineralization in situ. Randomized, double-blind, cross-over studies involved mouthrinses and dentifrices containing CPP-ACP and fluoride. The mouthrinses were used for 60 sec, three times/day for 5 days, and supragingival plaque was collected and analyzed for F. The dentifrices were rinsed as a water slurry for 60 sec four times/day for 14 days in an in situ model. The addition of 2% CPP-ACP to the 450-ppm-F mouthrinse significantly increased the incorporation of fluoride into plaque. The dentifrice containing 2% CPP-ACP produced a level of remineralization similar to that achieved with a dentifrice containing 2800 ppm F. The dentifrice containing 2% CPP-ACP plus 1100 ppm F was superior to all other formulations.Casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) slows the progression of caries and remineralizes enamel subsurface lesions. The aim of this study was to determine the ability of CPP-ACP to increase the incorporation of fluoride into plaque and to promote enamel remineralization in situ. Randomized, double-blind, cross-over studies involved mouthrinses and dentifrices containing CPP-ACP and fluoride. The mouthrinses were used for 60 sec, three times/day for 5 days, and supragingival plaque was collected and analyzed for F. The dentifrices were rinsed as a water slurry for 60 sec four times/day for 14 days in an in situ model. The addition of 2% CPP-ACP to the 450-ppm-F mouthrinse significantly increased the incorporation of fluoride into plaque. The dentifrice containing 2% CPP-ACP produced a level of remineralization similar to that achieved with a dentifrice containing 2800 ppm F. The dentifrice containing 2% CPP-ACP plus 1100 ppm F was superior to all other formulations.
Author	SHEN P. REYNOLDS C. CAI F. MORGAN M. V. WALKER G. D. COCHRANE N. J. REYNOLDS E. C.
Author_xml	– sequence: 1 givenname: E.C. surname: Reynolds fullname: Reynolds, E.C. organization: Cooperative Research Centre for Oral Health Science, School of Dental Science, Bio21 Institute, The University of Melbourne, 720 Swanston Street, Victoria 3000, Australia – sequence: 2 givenname: F. surname: Cai fullname: Cai, F. organization: Cooperative Research Centre for Oral Health Science, School of Dental Science, Bio21 Institute, The University of Melbourne, 720 Swanston Street, Victoria 3000, Australia – sequence: 3 givenname: N.J. surname: Cochrane fullname: Cochrane, N.J. organization: Cooperative Research Centre for Oral Health Science, School of Dental Science, Bio21 Institute, The University of Melbourne, 720 Swanston Street, Victoria 3000, Australia – sequence: 4 givenname: P. surname: Shen fullname: Shen, P. organization: Cooperative Research Centre for Oral Health Science, School of Dental Science, Bio21 Institute, The University of Melbourne, 720 Swanston Street, Victoria 3000, Australia – sequence: 5 givenname: G.D. surname: Walker fullname: Walker, G.D. organization: Cooperative Research Centre for Oral Health Science, School of Dental Science, Bio21 Institute, The University of Melbourne, 720 Swanston Street, Victoria 3000, Australia – sequence: 6 givenname: M.V. surname: Morgan fullname: Morgan, M.V. organization: Cooperative Research Centre for Oral Health Science, School of Dental Science, Bio21 Institute, The University of Melbourne, 720 Swanston Street, Victoria 3000, Australia – sequence: 7 givenname: C. surname: Reynolds fullname: Reynolds, C. organization: Cooperative Research Centre for Oral Health Science, School of Dental Science, Bio21 Institute, The University of Melbourne, 720 Swanston Street, Victoria 3000, Australia
BackLink	https://cir.nii.ac.jp/crid/1570291225643347968$$DView record in CiNii https://www.ncbi.nlm.nih.gov/pubmed/18362316$$D View this record in MEDLINE/PubMed
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Copyright	International and American Associations for Dental Research Copyright American Association for Dental Research/American Academy of Implant Dentistry Apr 2008
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Keywords	fluoride casein phosphopeptide-amorphous calcium phosphate acid resistance plaque uptake enamel subsurface lesion remineralization
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Snippet	Casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) slows the progression of caries and remineralizes enamel subsurface lesions. The aim of this study...
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SubjectTerms	acid resistance Adult Apatites - analysis Cariostatic Agents - administration & dosage Cariostatic Agents - pharmacokinetics Cariostatic Agents - therapeutic use casein phosphopeptide-amorphous calcium phosphate Caseins - administration & dosage Caseins - therapeutic use Chemistry, Pharmaceutical Cross-Over Studies Dental Enamel - metabolism Dental Plaque - metabolism Dentifrices - therapeutic use Double-Blind Method Drug Combinations Electron Probe Microanalysis enamel subsurface lesion remineralization Female fluoride Fluorides - administration & dosage Fluorides - pharmacokinetics Fluorides - therapeutic use Humans Male Middle Aged Mouthwashes - therapeutic use Placebos plaque uptake Sodium Fluoride - administration & dosage Sodium Fluoride - therapeutic use Tooth Remineralization - methods
Title	Fluoride and Casein Phosphopeptide-Amorphous Calcium Phosphate
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