Fluoride and Casein Phosphopeptide-Amorphous Calcium Phosphate

Casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) slows the progression of caries and remineralizes enamel subsurface lesions. The aim of this study was to determine the ability of CPP-ACP to increase the incorporation of fluoride into plaque and to promote enamel remineralization in situ....

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Bibliographic Details
Published in:Journal of dental research Vol. 87; no. 4; pp. 344 - 348
Main Authors: Reynolds, E.C., Cai, F., Cochrane, N.J., Shen, P., Walker, G.D., Morgan, M.V., Reynolds, C.
Format: Journal Article
Language:English
Published: United States SAGE Publications 01.04.2008
SAGE PUBLICATIONS, INC
Subjects:
acid resistance
Adult
Apatites - analysis
Cariostatic Agents - administration & dosage
Cariostatic Agents - pharmacokinetics
Cariostatic Agents - therapeutic use
casein phosphopeptide-amorphous calcium phosphate
Caseins - administration & dosage
Caseins - therapeutic use
Chemistry, Pharmaceutical
Cross-Over Studies
Dental Enamel - metabolism
Dental Plaque - metabolism
Dentifrices - therapeutic use
Double-Blind Method
Drug Combinations
Electron Probe Microanalysis
enamel subsurface lesion remineralization
Female
fluoride
Fluorides - administration & dosage
Fluorides - pharmacokinetics
Fluorides - therapeutic use
Humans
Male
Middle Aged
Mouthwashes - therapeutic use
Placebos
plaque uptake
Sodium Fluoride - administration & dosage
Sodium Fluoride - therapeutic use
Tooth Remineralization - methods
fluoride
casein phosphopeptide-amorphous calcium phosphate
acid resistance
plaque uptake
enamel subsurface lesion remineralization
ISSN:0022-0345, 1544-0591
Online Access:Get full text
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Summary:Casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) slows the progression of caries and remineralizes enamel subsurface lesions. The aim of this study was to determine the ability of CPP-ACP to increase the incorporation of fluoride into plaque and to promote enamel remineralization in situ. Randomized, double-blind, cross-over studies involved mouthrinses and dentifrices containing CPP-ACP and fluoride. The mouthrinses were used for 60 sec, three times/day for 5 days, and supragingival plaque was collected and analyzed for F. The dentifrices were rinsed as a water slurry for 60 sec four times/day for 14 days in an in situ model. The addition of 2% CPP-ACP to the 450-ppm-F mouthrinse significantly increased the incorporation of fluoride into plaque. The dentifrice containing 2% CPP-ACP produced a level of remineralization similar to that achieved with a dentifrice containing 2800 ppm F. The dentifrice containing 2% CPP-ACP plus 1100 ppm F was superior to all other formulations.
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ISSN:0022-0345
1544-0591
DOI:10.1177/154405910808700420