p97/VCP- and Lys48-linked polyubiquitination form a new signaling pathway in DNA damage response

RNF8/RNF168-dependent Lys63-linked polyubiquitination at sites of DNA double-strand breaks (DSBs) was originally regarded as the sole ubiquitin-signaling pathway involved in the DNA damage response (DDR). However, ubiquitin-dependent p97/VCP segregase activity and RNF8-dependent Lys48-linked polyubi...

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Bibliographic Details
Published in:	Cell cycle (Georgetown, Tex.) Vol. 11; no. 6; pp. 1062 - 1069
Main Author:	Ramadan, Kristijan
Format:	Journal Article
Language:	English
Published:	United States Taylor & Francis 15.03.2012
Subjects:	Adenosine Triphosphatases - genetics Adenosine Triphosphatases - metabolism Binding Binding Sites Biology Bioscience BRCA1 Protein - genetics BRCA1 Protein - metabolism Calcium Cancer Cell Cell Cycle Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Chromatin - genetics Chromatin - metabolism Cycle DNA Breaks, Double-Stranded DNA damage response DNA double strand breaks DNA Repair DNA Replication DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Enzyme Activation genome stability Humans Landes Lys48 ubiquitin chain Lysine - genetics Lysine - metabolism Models, Genetic Organogenesis p97/VCP Proteasome Endopeptidase Complex - genetics Proteasome Endopeptidase Complex - metabolism Protein Binding Proteins Proteolysis Signal Transduction Substrate Specificity ubiquitin-proteasome system Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism Ubiquitination Valosin Containing Protein
ISSN:	1538-4101, 1551-4005, 1551-4005
Online Access:	Get full text
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