p97/VCP- and Lys48-linked polyubiquitination form a new signaling pathway in DNA damage response

RNF8/RNF168-dependent Lys63-linked polyubiquitination at sites of DNA double-strand breaks (DSBs) was originally regarded as the sole ubiquitin-signaling pathway involved in the DNA damage response (DDR). However, ubiquitin-dependent p97/VCP segregase activity and RNF8-dependent Lys48-linked polyubi...

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Bibliographic Details
Published in:Cell cycle (Georgetown, Tex.) Vol. 11; no. 6; pp. 1062 - 1069
Main Author: Ramadan, Kristijan
Format: Journal Article
Language:English
Published: United States Taylor & Francis 15.03.2012
Subjects:
Adenosine Triphosphatases - genetics
Adenosine Triphosphatases - metabolism
Binding
Binding Sites
Biology
Bioscience
BRCA1 Protein - genetics
BRCA1 Protein - metabolism
Calcium
Cancer
Cell
Cell Cycle
Cell Cycle Proteins - genetics
Cell Cycle Proteins - metabolism
Chromatin - genetics
Chromatin - metabolism
Cycle
DNA Breaks, Double-Stranded
DNA damage response
DNA double strand breaks
DNA Repair
DNA Replication
DNA-Binding Proteins - genetics
DNA-Binding Proteins - metabolism
Enzyme Activation
genome stability
Humans
Landes
Lys48 ubiquitin chain
Lysine - genetics
Lysine - metabolism
Models, Genetic
Organogenesis
p97/VCP
Proteasome Endopeptidase Complex - genetics
Proteasome Endopeptidase Complex - metabolism
Protein Binding
Proteins
Proteolysis
Signal Transduction
Substrate Specificity
ubiquitin-proteasome system
Ubiquitin-Protein Ligases - genetics
Ubiquitin-Protein Ligases - metabolism
Ubiquitination
Valosin Containing Protein
ISSN:1538-4101, 1551-4005, 1551-4005
Online Access:Get full text
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Description
Summary:RNF8/RNF168-dependent Lys63-linked polyubiquitination at sites of DNA double-strand breaks (DSBs) was originally regarded as the sole ubiquitin-signaling pathway involved in the DNA damage response (DDR). However, ubiquitin-dependent p97/VCP segregase activity and RNF8-dependent Lys48-linked polyubiquitin chains at DSB sites have recently been identified as components of an additional and parallel ubiquitin-signaling DDR pathway. This newly identified pathway is essential to spatiotemporal protein turnover and regulates both main branches of DSB repair, homologous recombination and nonhomologous end joining. In this report, the function of the RNF8/Lys48 polyubiquitin chains/p97 pathway is discussed in the context of DSB repair and p97 chromatin-related functions.
Bibliography:ObjectType-Article-1
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ISSN:1538-4101
1551-4005
1551-4005
DOI:10.4161/cc.11.6.19446