p97/VCP- and Lys48-linked polyubiquitination form a new signaling pathway in DNA damage response

RNF8/RNF168-dependent Lys63-linked polyubiquitination at sites of DNA double-strand breaks (DSBs) was originally regarded as the sole ubiquitin-signaling pathway involved in the DNA damage response (DDR). However, ubiquitin-dependent p97/VCP segregase activity and RNF8-dependent Lys48-linked polyubi...

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Vydané v:	Cell cycle (Georgetown, Tex.) Ročník 11; číslo 6; s. 1062 - 1069
Hlavný autor:	Ramadan, Kristijan
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States Taylor & Francis 15.03.2012
Predmet:	Adenosine Triphosphatases - genetics Adenosine Triphosphatases - metabolism Binding Binding Sites Biology Bioscience BRCA1 Protein - genetics BRCA1 Protein - metabolism Calcium Cancer Cell Cell Cycle Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Chromatin - genetics Chromatin - metabolism Cycle DNA Breaks, Double-Stranded DNA damage response DNA double strand breaks DNA Repair DNA Replication DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Enzyme Activation genome stability Humans Landes Lys48 ubiquitin chain Lysine - genetics Lysine - metabolism Models, Genetic Organogenesis p97/VCP Proteasome Endopeptidase Complex - genetics Proteasome Endopeptidase Complex - metabolism Protein Binding Proteins Proteolysis Signal Transduction Substrate Specificity ubiquitin-proteasome system Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism Ubiquitination Valosin Containing Protein
ISSN:	1538-4101, 1551-4005, 1551-4005
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Shrnutí:	RNF8/RNF168-dependent Lys63-linked polyubiquitination at sites of DNA double-strand breaks (DSBs) was originally regarded as the sole ubiquitin-signaling pathway involved in the DNA damage response (DDR). However, ubiquitin-dependent p97/VCP segregase activity and RNF8-dependent Lys48-linked polyubiquitin chains at DSB sites have recently been identified as components of an additional and parallel ubiquitin-signaling DDR pathway. This newly identified pathway is essential to spatiotemporal protein turnover and regulates both main branches of DSB repair, homologous recombination and nonhomologous end joining. In this report, the function of the RNF8/Lys48 polyubiquitin chains/p97 pathway is discussed in the context of DSB repair and p97 chromatin-related functions.
Bibliografia:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1538-4101 1551-4005 1551-4005
DOI:	10.4161/cc.11.6.19446