Multigenerational epigenetic inheritance: Transmitting information across generations

Inherited epigenetic information has been observed to regulate a variety of complex organismal phenotypes across diverse taxa of life. This continually expanding body of literature suggests that epigenetic inheritance plays a significant, and potentially fundamental, role in inheritance. Despite the...

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Vydané v:Seminars in cell & developmental biology Ročník 127; s. 121 - 132
Hlavní autori: Burton, Nicholas O., Greer, Eric L.
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: England Elsevier Ltd 01.07.2022
Predmet:
DNA methylation
DNA Methylation - genetics
Epigenesis, Genetic - genetics
Epigenetics
Epigenomics
Heredity
Histone methylation
Inheritance Patterns - genetics
Intergenerational
Non-genetic
Non-Mendellian
Phenotype
Small RNAs
Transgenerational epigenetic inheritance
Histone methylation
Non-genetic
Transgenerational epigenetic inheritance
DNA methylation
Epigenetics
Intergenerational
Small RNAs
Non-Mendellian
ISSN:1084-9521, 1096-3634, 1096-3634
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Shrnutí:Inherited epigenetic information has been observed to regulate a variety of complex organismal phenotypes across diverse taxa of life. This continually expanding body of literature suggests that epigenetic inheritance plays a significant, and potentially fundamental, role in inheritance. Despite the important role these types of effects play in biology, the molecular mediators of this non-genetic transmission of information are just now beginning to be deciphered. Here we provide an intellectual framework for interpreting these findings and how they can interact with each other. We also define the different types of mechanisms that have been found to mediate epigenetic inheritance and to regulate whether epigenetic information persists for one or many generations. The field of epigenetic inheritance is entering an exciting phase, in which we are beginning to understand the mechanisms by which non-genetic information is transmitted to, and deciphered by, subsequent generations to maintain essential environmental information without permanently altering the genetic code. A more complete understanding of how and when epigenetic inheritance occurs will advance our understanding of numerous different aspects of biology ranging from how organisms cope with changing environments to human pathologies influenced by a parent’s environment.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
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content type line 23
ISSN:1084-9521
1096-3634
1096-3634
DOI:10.1016/j.semcdb.2021.08.006