Soluble amyloid beta-protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration

Alzheimer disease is a major cause of cognitive failure, and a pathogenically related but more subtle process accounts for many cases of mild memory symptoms in older humans. Insoluble fibrillar plaques of amyloid β-proteins (Aβ) and neurofibrillary deposits of hyperphosphorylated tau proteins are t...

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Bibliographic Details
Published in:	Proceedings of the National Academy of Sciences - PNAS Vol. 108; no. 14; p. 5819
Main Authors:	Jin, Ming, Shepardson, Nina, Yang, Ting, Chen, Gang, Walsh, Dominic, Selkoe, Dennis J
Format:	Journal Article
Language:	English
Published:	United States 05.04.2011
Subjects:	Alzheimer Disease - physiopathology Amyloid beta-Peptides - metabolism Amyloid beta-Peptides - pharmacology Animals Blotting, Western Chromatography, Gel Dimerization Genetic Vectors - genetics Hippocampus - cytology Humans Immunohistochemistry Immunoprecipitation In Situ Nick-End Labeling Lentivirus Microscopy, Confocal Microtubules - drug effects Neurites - drug effects Neurites - pathology Phosphorylation - drug effects Rats Rats, Sprague-Dawley tau Proteins - metabolism
ISSN:	1091-6490, 1091-6490
Online Access:	Get more information
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