USP15 Deubiquitinase Safeguards Hematopoiesis and Genome Integrity in Hematopoietic Stem Cells and Leukemia Cells

Altering ubiquitination by disruption of deubiquitinating enzymes (DUBs) affects hematopoietic stem cell (HSC) maintenance. However, comprehensive knowledge of DUB function during hematopoiesis in vivo is lacking. Here, we systematically inactivate DUBs in mouse hematopoietic progenitors using in vi...

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Veröffentlicht in:	Cell reports (Cambridge) Jg. 33; H. 13; S. 108533
Hauptverfasser:	van den Berk, Paul, Lancini, Cesare, Company, Carlos, Serresi, Michela, Sanchez-Bailon, Maria Pilar, Hulsman, Danielle, Pritchard, Colin, Song, Ji-Ying, Schmitt, Matthias Jürgen, Tanger, Ellen, Popp, Oliver, Mertins, Philipp, Huijbers, Ivo J., Jacobs, Heinz, van Lohuizen, Maarten, Gargiulo, Gaetano, Citterio, Elisabetta
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Elsevier Inc 29.12.2020 Cell Press
Schlagworte:	deubiquitinase deubiquitinating enzymes DNA damage response FUS fused in sarcoma genome integrity hematopoietic stem cell HSC in vivo shRNA screen leukemia RNAi USP15 leukemia USP15 RNAi DNA damage response FUS deubiquitinating enzymes in vivo shRNA screen hematopoietic stem cell HSC genome integrity deubiquitinase fused in sarcoma
ISSN:	2211-1247, 2211-1247
Online-Zugang:	Volltext
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