Making apples from oranges: Comparing noncollapsible effect estimators and their standard errors after adjustment for different covariate sets
We revisit the well‐known but often misunderstood issue of (non)collapsibility of effect measures in regression models for binary and time‐to‐event outcomes. We describe an existing simple but largely ignored procedure for marginalizing estimates of conditional odds ratios and propose a similar proc...
Saved in:
| Published in: | Biometrical journal Vol. 63; no. 3; pp. 528 - 557 |
|---|---|
| Main Authors: | , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Germany
Wiley - VCH Verlag GmbH & Co. KGaA
01.03.2021
John Wiley and Sons Inc |
| Subjects: | |
| ISSN: | 0323-3847, 1521-4036, 1521-4036 |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | We revisit the well‐known but often misunderstood issue of (non)collapsibility of effect measures in regression models for binary and time‐to‐event outcomes. We describe an existing simple but largely ignored procedure for marginalizing estimates of conditional odds ratios and propose a similar procedure for marginalizing estimates of conditional hazard ratios (allowing for right censoring), demonstrating its performance in simulation studies and in a reanalysis of data from a small randomized trial in primary biliary cirrhosis patients. In addition, we aim to provide an educational summary of issues surrounding (non)collapsibility from a causal inference perspective and to promote the idea that the words conditional and adjusted (likewise marginal and unadjusted) should not be used interchangeably. |
|---|---|
| Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 |
| ISSN: | 0323-3847 1521-4036 1521-4036 |
| DOI: | 10.1002/bimj.201900297 |