The expression of GLP‐1 receptor mRNA and protein allows the effect of GLP‐1 on glucose metabolism in the human hypothalamus and brainstem

In the present work, several experimental approaches were used to determine the presence of the glucagon‐like peptide‐1 receptor (GLP‐1R) and the biological actions of its ligand in the human brain. In situ hybridization histochemistry revealed specific labelling for GLP‐1 receptor mRNA in several b...

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Bibliographic Details
Published in:	Journal of neurochemistry Vol. 92; no. 4; pp. 798 - 806
Main Authors:	Alvarez, Elvira, Martínez, M. Dolores, Roncero, Isabel, Chowen, Julie A., García‐Cuartero, Beatriz, Gispert, Juan D., Sanz, Carmen, Vázquez, Patricia, Maldonado, Antonio, De Cáceres, Javier, Desco, Manuel, Pozo, Miguel Angel, Blázquez, Enrique
Format:	Journal Article
Language:	English
Published:	Oxford, UK Blackwell Science Ltd 01.02.2005 Blackwell
Subjects:	Adult Aged Aged, 80 and over Biological and medical sciences biological effects Brain Stem - metabolism Cell receptors Cell structures and functions Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Female Fundamental and applied biological sciences. Psychology gene expression Glucagon - metabolism Glucagon - physiology Glucagon-Like Peptide 1 Glucagon-Like Peptide-1 Receptor Glucose - metabolism glucose sensing human brain Humans Hypothalamus - metabolism Male Medical sciences Middle Aged Molecular and cellular biology Monoamines receptors (catecholamine, serotonine, histamine, acetylcholine) Neurology Peptide Fragments - metabolism Peptide Fragments - physiology Protein Binding - physiology Protein Precursors - metabolism Protein Precursors - physiology Receptors, Glucagon - biosynthesis Receptors, Glucagon - genetics RNA, Messenger - biosynthesis Human Phosphates Statistical analysis Enzyme Transferases GLP-1 receptor Central nervous system Glucose Hypothalamus Gene expression Metabolism Statistical study Protein biological effects Encephalon human brain Glucokinase GLUT-1 glucose transporter glucagon-like peptide-1 receptor glucose sensing Positron Emission tomography
ISSN:	0022-3042, 1471-4159
Online Access:	Get full text
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