Single-Biocatalyst Synthesis of Enantiopure d-Arylalanines Exploiting an Engineered d-Amino Acid Dehydrogenase

A practical and efficient biocatalytic synthesis of aromatic d‐amino acids has been developed, based on the reductive amination of the corresponding α‐keto acids via a recombinant whole cell system composed of an engineered dehydrogenase and cofactor recycling apparatus. The reaction was shown to gi...

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Vydáno v:	Advanced synthesis & catalysis Ročník 358; číslo 20; s. 3298 - 3306
Hlavní autoři:	Parmeggiani, Fabio, Ahmed, Syed T., Thompson, Matthew P., Weise, Nicholas J., Galman, James L., Gahloth, Deepankar, Dunstan, Mark S., Leys, David, Turner, Nicholas J.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Blackwell Publishing Ltd 20.10.2016
Témata:	amino acids asymmetric synthesis biocatalysis Catalysis Catalysts Derivatives enzyme catalysis Enzymes oxidoreductases Recombinant Recycling Synthesis Synthesis (chemistry)
ISSN:	1615-4150, 1615-4169
On-line přístup:	Získat plný text
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