The expression of prostate stem cell antigen in human clear cell renal cell carcinoma: a quantitative reverse transcriptase‐polymerase chain reaction analysis
OBJECTIVES To analyse the gene expression level of prostate stem cell antigen (PSCA) in human clear cell renal cell carcinoma (CC‐RCC) and its relationship with conventional clinicopathological manifestations, to evaluate its prognostic value for patient outcome, and to determine the effect of PSCA...
Gespeichert in:
| Veröffentlicht in: | BJU international Jg. 98; H. 3; S. 668 - 673 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Journal Article |
| Sprache: | Englisch |
| Veröffentlicht: |
Oxford, UK
Blackwell Publishing Ltd
01.09.2006
Blackwell |
| Schlagworte: | |
| ISSN: | 1464-4096, 1464-410X |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| Abstract | OBJECTIVES
To analyse the gene expression level of prostate stem cell antigen (PSCA) in human clear cell renal cell carcinoma (CC‐RCC) and its relationship with conventional clinicopathological manifestations, to evaluate its prognostic value for patient outcome, and to determine the effect of PSCA on the progression of CC‐RCC.
PATIENTS AND METHODS
We quantified PSCA mRNA level in human RCC cell lines (ACHN, A704, KPK‐1, Caki‐1, and Caki‐2) and in 154 surgical tissue samples (81 from CC‐RCC, 73 from normal kidney) using real‐time reverse transcriptase‐polymerase chain reaction (RT‐PCR). The findings were analysed in relation to clinicopathological factors. Immunohistochemical expression was examined using confocal laser scanning light‐microscopy.
RESULTS
PSCA was overexpressed in all RCC cell lines. PSCA mRNA levels were significantly higher in CC‐RCC than in normal kidney tissue samples (P < 0.001), in G2‐G3 than in G1 tumours (P = 0.028), and in advanced disease (T3‐T4) than in organ‐confined (T1‐T2) tumours (P = 0.016). There was significantly higher PSCA mRNA expression in patients with M1 than in those with M0 disease (P = 0.029). Patients in whom the lesions had high PSCA expression levels had a significantly worse prognosis than those with low PSCA expression levels (P = 0.044). Using immunohistochemical analysis there was markedly greater PSCA expression in CC‐RCC than in normal kidney, and in advanced‐disease high‐grade tumours than in organ‐confined low‐grade tumours.
CONCLUSIONS
A significant correlation was detected in the gene expression level of PSCA with histological grade, clinicopathological stage and prognosis in CC‐RCC. Our data indicate that PSCA is associated with carcinogenesis and progression of CC‐RCC. |
|---|---|
| AbstractList | To analyse the gene expression level of prostate stem cell antigen (PSCA) in human clear cell renal cell carcinoma (CC-RCC) and its relationship with conventional clinicopathological manifestations, to evaluate its prognostic value for patient outcome, and to determine the effect of PSCA on the progression of CC-RCC.OBJECTIVESTo analyse the gene expression level of prostate stem cell antigen (PSCA) in human clear cell renal cell carcinoma (CC-RCC) and its relationship with conventional clinicopathological manifestations, to evaluate its prognostic value for patient outcome, and to determine the effect of PSCA on the progression of CC-RCC.We quantified PSCA mRNA level in human RCC cell lines (ACHN, A704, KPK-1, Caki-1, and Caki-2) and in 154 surgical tissue samples (81 from CC-RCC, 73 from normal kidney) using real-time reverse transcriptase-polymerase chain reaction (RT-PCR). The findings were analysed in relation to clinicopathological factors. Immunohistochemical expression was examined using confocal laser scanning light-microscopy.PATIENTS AND METHODSWe quantified PSCA mRNA level in human RCC cell lines (ACHN, A704, KPK-1, Caki-1, and Caki-2) and in 154 surgical tissue samples (81 from CC-RCC, 73 from normal kidney) using real-time reverse transcriptase-polymerase chain reaction (RT-PCR). The findings were analysed in relation to clinicopathological factors. Immunohistochemical expression was examined using confocal laser scanning light-microscopy.PSCA was overexpressed in all RCC cell lines. PSCA mRNA levels were significantly higher in CC-RCC than in normal kidney tissue samples (P < 0.001), in G2-G3 than in G1 tumours (P = 0.028), and in advanced disease (T3-T4) than in organ-confined (T1-T2) tumours (P = 0.016). There was significantly higher PSCA mRNA expression in patients with M1 than in those with M0 disease (P = 0.029). Patients in whom the lesions had high PSCA expression levels had a significantly worse prognosis than those with low PSCA expression levels (P = 0.044). Using immunohistochemical analysis there was markedly greater PSCA expression in CC-RCC than in normal kidney, and in advanced-disease high-grade tumours than in organ-confined low-grade tumours.RESULTSPSCA was overexpressed in all RCC cell lines. PSCA mRNA levels were significantly higher in CC-RCC than in normal kidney tissue samples (P < 0.001), in G2-G3 than in G1 tumours (P = 0.028), and in advanced disease (T3-T4) than in organ-confined (T1-T2) tumours (P = 0.016). There was significantly higher PSCA mRNA expression in patients with M1 than in those with M0 disease (P = 0.029). Patients in whom the lesions had high PSCA expression levels had a significantly worse prognosis than those with low PSCA expression levels (P = 0.044). Using immunohistochemical analysis there was markedly greater PSCA expression in CC-RCC than in normal kidney, and in advanced-disease high-grade tumours than in organ-confined low-grade tumours.A significant correlation was detected in the gene expression level of PSCA with histological grade, clinicopathological stage and prognosis in CC-RCC. Our data indicate that PSCA is associated with carcinogenesis and progression of CC-RCC.CONCLUSIONSA significant correlation was detected in the gene expression level of PSCA with histological grade, clinicopathological stage and prognosis in CC-RCC. Our data indicate that PSCA is associated with carcinogenesis and progression of CC-RCC. To analyse the gene expression level of prostate stem cell antigen (PSCA) in human clear cell renal cell carcinoma (CC-RCC) and its relationship with conventional clinicopathological manifestations, to evaluate its prognostic value for patient outcome, and to determine the effect of PSCA on the progression of CC-RCC. We quantified PSCA mRNA level in human RCC cell lines (ACHN, A704, KPK-1, Caki-1, and Caki-2) and in 154 surgical tissue samples (81 from CC-RCC, 73 from normal kidney) using real-time reverse transcriptase-polymerase chain reaction (RT-PCR). The findings were analysed in relation to clinicopathological factors. Immunohistochemical expression was examined using confocal laser scanning light-microscopy. PSCA was overexpressed in all RCC cell lines. PSCA mRNA levels were significantly higher in CC-RCC than in normal kidney tissue samples (P < 0.001), in G2-G3 than in G1 tumours (P = 0.028), and in advanced disease (T3-T4) than in organ-confined (T1-T2) tumours (P = 0.016). There was significantly higher PSCA mRNA expression in patients with M1 than in those with M0 disease (P = 0.029). Patients in whom the lesions had high PSCA expression levels had a significantly worse prognosis than those with low PSCA expression levels (P = 0.044). Using immunohistochemical analysis there was markedly greater PSCA expression in CC-RCC than in normal kidney, and in advanced-disease high-grade tumours than in organ-confined low-grade tumours. A significant correlation was detected in the gene expression level of PSCA with histological grade, clinicopathological stage and prognosis in CC-RCC. Our data indicate that PSCA is associated with carcinogenesis and progression of CC-RCC. OBJECTIVES To analyse the gene expression level of prostate stem cell antigen (PSCA) in human clear cell renal cell carcinoma (CC‐RCC) and its relationship with conventional clinicopathological manifestations, to evaluate its prognostic value for patient outcome, and to determine the effect of PSCA on the progression of CC‐RCC. PATIENTS AND METHODS We quantified PSCA mRNA level in human RCC cell lines (ACHN, A704, KPK‐1, Caki‐1, and Caki‐2) and in 154 surgical tissue samples (81 from CC‐RCC, 73 from normal kidney) using real‐time reverse transcriptase‐polymerase chain reaction (RT‐PCR). The findings were analysed in relation to clinicopathological factors. Immunohistochemical expression was examined using confocal laser scanning light‐microscopy. RESULTS PSCA was overexpressed in all RCC cell lines. PSCA mRNA levels were significantly higher in CC‐RCC than in normal kidney tissue samples (P < 0.001), in G2‐G3 than in G1 tumours (P = 0.028), and in advanced disease (T3‐T4) than in organ‐confined (T1‐T2) tumours (P = 0.016). There was significantly higher PSCA mRNA expression in patients with M1 than in those with M0 disease (P = 0.029). Patients in whom the lesions had high PSCA expression levels had a significantly worse prognosis than those with low PSCA expression levels (P = 0.044). Using immunohistochemical analysis there was markedly greater PSCA expression in CC‐RCC than in normal kidney, and in advanced‐disease high‐grade tumours than in organ‐confined low‐grade tumours. CONCLUSIONS A significant correlation was detected in the gene expression level of PSCA with histological grade, clinicopathological stage and prognosis in CC‐RCC. Our data indicate that PSCA is associated with carcinogenesis and progression of CC‐RCC. |
| Author | ELSAMMAN, ESSAM M. FUKUMORI, TOMOHARU TAKAHASHI, MASAYUKI TOIDA, KAZUNORI NAKANISHI, RYOICHI KANAYAMA, HIRO‐OMI TANIMOTO, SHUJI |
| Author_xml | – sequence: 1 givenname: ESSAM M. surname: ELSAMMAN fullname: ELSAMMAN, ESSAM M. – sequence: 2 givenname: TOMOHARU surname: FUKUMORI fullname: FUKUMORI, TOMOHARU – sequence: 3 givenname: SHUJI surname: TANIMOTO fullname: TANIMOTO, SHUJI – sequence: 4 givenname: RYOICHI surname: NAKANISHI fullname: NAKANISHI, RYOICHI – sequence: 5 givenname: MASAYUKI surname: TAKAHASHI fullname: TAKAHASHI, MASAYUKI – sequence: 6 givenname: KAZUNORI surname: TOIDA fullname: TOIDA, KAZUNORI – sequence: 7 givenname: HIRO‐OMI surname: KANAYAMA fullname: KANAYAMA, HIRO‐OMI |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18021927$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/16925770$$D View this record in MEDLINE/PubMed |
| BookMark | eNqNkc1u1DAQxy1URD_gFZAvcNtgx4njIIFUKj5ViUsrcbNmvRPWK8dJ7aTs3niEPkKfjSfBabZU4lRfPPb85m_P_I_Jge88EkI5y3habzYZL2SxKDj7keWMyYxJUbJs-4Qc_Usc3MeslofkOMYNY-lCls_IIZd1XlYVOyK3F2ukuO0Dxmg7T7uG9qGLAwxI44AtNegcBT_Yn-ip9XQ9tuCpcQhhzgX04ObQQDDWdy28pUCvxqkqCdlrTNA1hoh0COCjCbYfIOKf3zd953YthnSgZg1JPiCYYfoIJNVdtPE5edqAi_hiv5-Qy08fL86-LM6_f_56dnq-MIUUbLFalbwBjmXDDSuUqJYFE0suJFeqKnlueF3XKcFVgyupGBgsQC6xUqwAIYw4Ia9n3dT-1Yhx0K2NU1fgsRujlqqqVHopgS_34LhscaX7YFsIO30_0wS82gMQDbgmtWxsfOAUy3mdV4lTM2fSwGPA5gFherJZb_TkoJ7c1JPN-s5mvU2l7_8rNXeT7nwasHWPEXg3C_yyDnePflh_-HY5ReIvVO3FSQ |
| CitedBy_id | crossref_primary_10_1002_med_20165 crossref_primary_10_1016_j_ymeth_2009_03_021 crossref_primary_10_1002_ijc_25740 crossref_primary_10_1586_14737140_2014_845372 crossref_primary_10_1016_j_gene_2013_08_058 crossref_primary_10_1186_1756_0500_5_371 crossref_primary_10_1155_2020_5395312 crossref_primary_10_1186_s12935_024_03320_6 crossref_primary_10_1089_gtmb_2022_0067 crossref_primary_10_1111_hel_12183 crossref_primary_10_5483_BMBRep_2012_45_11_210 crossref_primary_10_1016_j_canlet_2008_08_034 crossref_primary_10_1158_1078_0432_CCR_09_3169 crossref_primary_10_4049_jimmunol_1400330 crossref_primary_10_1016_j_eursup_2007_05_003 crossref_primary_10_1111_cas_12042 crossref_primary_10_1089_dna_2009_0960 crossref_primary_10_3390_cancers14081925 crossref_primary_10_1007_s10555_009_9190_y crossref_primary_10_3389_fphar_2023_970457 crossref_primary_10_1093_carcin_bgp323 crossref_primary_10_1093_carcin_bgw010 crossref_primary_10_1002_pros_20973 crossref_primary_10_1186_s12885_018_4547_7 crossref_primary_10_3390_pharmaceutics13050676 crossref_primary_10_3390_cancers15204917 crossref_primary_10_1016_j_urolonc_2011_02_004 crossref_primary_10_1093_jnci_djs458 crossref_primary_10_1111_1751_2980_12309 crossref_primary_10_1038_s41585_018_0119_5 crossref_primary_10_1053_j_gastro_2010_11_001 crossref_primary_10_1155_2013_648420 crossref_primary_10_1002_ijc_23150 crossref_primary_10_1002_pros_20608 crossref_primary_10_1093_jjco_hyp181 crossref_primary_10_1002_mc_20718 crossref_primary_10_1007_s00432_012_1210_6 crossref_primary_10_1002_gcc_20928 crossref_primary_10_1038_s41598_019_40032_8 crossref_primary_10_1016_j_vaccine_2010_12_016 crossref_primary_10_1002_mc_20796 crossref_primary_10_1007_s00705_010_0635_y |
| Cites_doi | 10.1158/1078-0432.CCR-04-1842 10.1016/S0165-2478(96)02682-X 10.1073/pnas.95.4.1735 10.1002/cne.20760 10.1006/bbrc.2000.3393 10.1084/jem.183.5.2355 10.1016/S0304-3835(01)00497-9 10.1111/j.1464-410X.2006.06153.x 10.1007/s11934-002-0010-y 10.1002/(SICI)1098-2264(200001)27:1<95::AID-GCC12>3.0.CO;2-3 10.1016/S0022-5347(05)67889-5 10.1083/jcb.129.6.1677 10.1073/pnas.92.10.4294 10.1016/S0006-8993(02)04244-0 10.1016/S0021-9258(19)49841-4 10.1016/S0090-4295(01)01601-6 10.1038/sj.onc.1203426 10.1097/01.ju.0000109982.60619.93 10.1002/ijc.2910590517 10.1093/jjco/hyh073 10.1073/pnas.012574899 10.1016/S0090-4295(98)00132-0 10.1016/S0022-5347(17)53357-1 |
| ContentType | Journal Article |
| Copyright | 2006 INIST-CNRS |
| Copyright_xml | – notice: 2006 INIST-CNRS |
| DBID | AAYXX CITATION IQODW CGR CUY CVF ECM EIF NPM 7X8 |
| DOI | 10.1111/j.1464-410X.2006.06350.x |
| DatabaseName | CrossRef Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1464-410X |
| EndPage | 673 |
| ExternalDocumentID | 16925770 18021927 10_1111_j_1464_410X_2006_06350_x BJU6350 |
| Genre | article Journal Article |
| GroupedDBID | --- .3N .55 .GA .Y3 05W 0R~ 10A 1OC 23N 24P 2WC 31~ 33P 36B 3O- 3SF 4.4 50Y 50Z 51W 51X 52M 52N 52O 52P 52R 52S 52T 52U 52V 52W 52X 53G 5GY 5HH 5LA 5RE 5VS 66C 6P2 702 7PT 8-0 8-1 8-3 8-4 8-5 8UM 930 A01 A03 AAESR AAEVG AAHHS AAHQN AAIPD AAMNL AANLZ AAONW AASGY AAXRX AAYCA AAZKR ABCQN ABCUV ABDBF ABEML ABJNI ABLJU ABOCM ABPVW ABQWH ABXGK ACAHQ ACCFJ ACCZN ACFBH ACGFS ACGOF ACMXC ACPOU ACPRK ACSCC ACUHS ACXBN ACXQS ADBBV ADBTR ADEOM ADIZJ ADKYN ADMGS ADOZA ADXAS ADZMN ADZOD AEEZP AEIGN AEIMD AENEX AEQDE AEUQT AEUYR AFBPY AFEBI AFFNX AFFPM AFGKR AFPWT AFWVQ AFZJQ AHBTC AHMBA AIACR AITYG AIURR AIWBW AJBDE ALAGY ALMA_UNASSIGNED_HOLDINGS ALUQN ALVPJ AMBMR AMYDB ATUGU AZBYB AZVAB BAFTC BAWUL BFHJK BHBCM BMXJE BROTX BRXPI BY8 C45 CAG COF CS3 D-6 D-7 D-E D-F DCZOG DIK DPXWK DR2 DRFUL DRMAN DRSTM DU5 E3Z EAD EAP EBC EBD EBS EJD EMB EMK EMOBN ESX EX3 F00 F01 F04 F5P FUBAC G-S G.N GODZA H.X HF~ HGLYW HZI HZ~ IHE IX1 J0M J5H K48 KBYEO LATKE LC2 LC3 LEEKS LH4 LITHE LOXES LP6 LP7 LUTES LW6 LYRES MEWTI MK4 MRFUL MRMAN MRSTM MSFUL MSMAN MSSTM MXFUL MXMAN MXSTM N04 N05 N9A NF~ O66 O9- OIG OK1 OVD P2P P2W P2X P2Z P4B P4D PQQKQ Q.N Q11 QB0 R.K RJQFR ROL RX1 SUPJJ SV3 TEORI TUS UB1 V9Y W8V W99 WBKPD WHWMO WIH WIJ WIK WOHZO WOW WQJ WRC WVDHM WXI WXSBR X7M XG1 YFH ZGI ZXP ~IA ~WT AAMMB AAYXX AEFGJ AEYWJ AGHNM AGXDD AGYGG AIDQK AIDYY AIQQE CITATION O8X IQODW CGR CUY CVF ECM EIF NPM 7X8 |
| ID | FETCH-LOGICAL-c4630-dd51fa1e5f1c04837b403b1361887512c199904818fed680ace4a6be7804a33c3 |
| IEDL.DBID | DRFUL |
| ISICitedReferencesCount | 55 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000240199500039&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 1464-4096 |
| IngestDate | Tue Oct 21 13:41:40 EDT 2025 Wed Feb 19 01:55:12 EST 2025 Mon Jul 21 09:14:52 EDT 2025 Sat Nov 29 06:57:50 EST 2025 Tue Nov 18 21:14:48 EST 2025 Wed Jan 22 16:31:17 EST 2025 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 3 |
| Keywords | Histological grading Nephrology Prognosis RNA-directed DNA polymerase PSCA Tumoral marker real-time RT-PCR Carcinogenesis Urology kidney Cancerology Histopathology Prostate stem cell antigen Grawitz tumor Reverse transcription polymerase chain reaction Quantitative analysis Kidney disease Human Urinary system disease Enzyme Transferases Malignant tumor Real time Anatomic pathology Nucleotidyltransferases Clear cell carcinoma Kidney cancer Molecular biology |
| Language | English |
| License | CC BY 4.0 |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c4630-dd51fa1e5f1c04837b403b1361887512c199904818fed680ace4a6be7804a33c3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| PMID | 16925770 |
| PQID | 68778630 |
| PQPubID | 23479 |
| PageCount | 6 |
| ParticipantIDs | proquest_miscellaneous_68778630 pubmed_primary_16925770 pascalfrancis_primary_18021927 crossref_primary_10_1111_j_1464_410X_2006_06350_x crossref_citationtrail_10_1111_j_1464_410X_2006_06350_x wiley_primary_10_1111_j_1464_410X_2006_06350_x_BJU6350 |
| PublicationCentury | 2000 |
| PublicationDate | September 2006 |
| PublicationDateYYYYMMDD | 2006-09-01 |
| PublicationDate_xml | – month: 09 year: 2006 text: September 2006 |
| PublicationDecade | 2000 |
| PublicationPlace | Oxford, UK |
| PublicationPlace_xml | – name: Oxford, UK – name: Oxford – name: England |
| PublicationTitle | BJU international |
| PublicationTitleAlternate | BJU Int |
| PublicationYear | 2006 |
| Publisher | Blackwell Publishing Ltd Blackwell |
| Publisher_xml | – name: Blackwell Publishing Ltd – name: Blackwell |
| References | 2001; 168 2002; 59 2006; 97 1995; 92 2005; 493 2000; 27 1982; 128 1992; 267 2002; 99 1998 1996; 183 2002; 3 2000; 275 1992 2003; 969 2001; 61 2000; 19 1997; 55 2002; 62 2004; 34 2004; 171 1995; 129 2000; 163 1994; 59 1998; 51 1998; 95 2005; 11 e_1_2_7_5_2 e_1_2_7_4_2 e_1_2_7_3_2 Ryu B (e_1_2_7_21_2) 2002; 62 e_1_2_7_9_2 e_1_2_7_8_2 e_1_2_7_7_2 e_1_2_7_6_2 e_1_2_7_19_2 e_1_2_7_18_2 e_1_2_7_17_2 e_1_2_7_16_2 e_1_2_7_14_2 e_1_2_7_11_2 e_1_2_7_10_2 The Japanese Urological Association. (e_1_2_7_15_2) 1992 e_1_2_7_26_2 e_1_2_7_27_2 e_1_2_7_28_2 e_1_2_7_29_2 Amara N (e_1_2_7_12_2) 2001; 61 Argani P (e_1_2_7_13_2) 2001; 61 e_1_2_7_25_2 e_1_2_7_24_2 e_1_2_7_23_2 e_1_2_7_22_2 e_1_2_7_20_2 Mostofi FK (e_1_2_7_2_2) 1998 |
| References_xml | – volume: 19 start-page: 1288 year: 2000 end-page: 96 article-title: Prostate stem cell antigen (PSCA) expression increases with high Gleason score, advanced stage and bone metastasis in prostate cancer publication-title: Oncogene – volume: 3 start-page: 44 year: 2002 end-page: 9 article-title: The role of adjuvant immunotherapy in renal cell carcinoma publication-title: Curr Urol Rep – volume: 59 start-page: 615 year: 2002 end-page: 20 article-title: Clinical significance of p53, mdm2, and bcl‐2 proteins in renal cell carcinoma publication-title: Urology – volume: 493 start-page: 381 year: 2005 end-page: 95 article-title: Localization of 5alpha‐reductase type 1 in the rat main olfactory bulb publication-title: J Comp Neurol – volume: 163 start-page: 408 year: 2000 end-page: 17 article-title: Systemic therapy for renal cell carcinoma publication-title: J Urol – volume: 267 start-page: 12317 year: 1992 end-page: 22 article-title: The glycophosphatidylinositol‐anchored Thy‐1 molecule interacts with the p60fyn protein tyrosine kinase in T cells publication-title: J Biol Chem – volume: 61 start-page: 4660 year: 2001 end-page: 5 article-title: Prostate stem cell antigen is overexpressed in human transitional cell carcinoma publication-title: Cancer Res – volume: 99 start-page: 401 year: 2002 end-page: 6 article-title: Growth, regeneration, and tumorigenesis of the prostate activates the PSCA promoter publication-title: Proc Natl Acad Sci USA – volume: 34 start-page: 414 year: 2004 end-page: 9 article-title: Prostate stem cell antigen (PSCA) expression in human prostate cancer tissues: implications for prostate carcinogenesis and progression of prostate cancer publication-title: Jpn J Clin Oncol – volume: 95 start-page: 1735 year: 1998 end-page: 40 article-title: Prostate stem cell antigen: a cell surface marker overexpressed in prostate cancer publication-title: Proc Natl Acad Sci USA – volume: 27 start-page: 95 year: 2000 end-page: 103 article-title: Coamplification of prostate stem cell antigen (PSCA) and MYC in locally advanced prostate cancer publication-title: Genes Chromosomes Cancer – volume: 51 start-page: 1057 year: 1998 end-page: 61 article-title: P53, bcl‐2, and Bax expression in renal cell carcinoma publication-title: Urology – year: 1992 – volume: 62 start-page: 819 year: 2002 end-page: 26 article-title: Relationships and differentially expressed genes among pancreatic cancers examined by large scale analysis of gene expression publication-title: Cancer Res – year: 1998 – volume: 171 start-page: 1117 year: 2004 end-page: 21 article-title: Prostate stem cell antigen expression is associated with Gleason score, seminal vesicle invasion and capsular invasion in prostate cancer publication-title: J Urol – volume: 59 start-page: 684 year: 1994 end-page: 91 article-title: An association between high Ly‐6A/E expression on tumor cells and a highly malignant phenotype publication-title: Int J Cancer – volume: 55 start-page: 47 year: 1997 end-page: 51 article-title: Stem cell antigen 2 expression in adult and developing mice publication-title: Immunol Lett – volume: 129 start-page: 1677 year: 1995 end-page: 89 article-title: The human E48 antigen, highly homologous to the murine Ly‐6 antigen ThB, is a GPI‐anchored molecule apparently involved in keratinocyte cell‐cell adhesion publication-title: J Cell Biol – volume: 168 start-page: 37 year: 2001 end-page: 43 article-title: PSCA expression is regulated by phorbol ester and cell adhesion in the bladder carcinoma cell line RT112 publication-title: Cancer Lett – volume: 97 start-page: 1202 year: 2006 end-page: 7 – volume: 92 start-page: 4294 year: 1995 end-page: 8 article-title: Overexpressed Ly‐6A.2 mediates cell‐cell adhesion by binding a ligand expressed on lymphoid cells publication-title: Proc Natl Acad Sci USA – volume: 11 start-page: 2591 year: 2005 end-page: 6 article-title: Prostate stem cell antigen is overexpressed in prostate cancer metastases publication-title: Clin Cancer Res – volume: 61 start-page: 4320 year: 2001 end-page: 4 article-title: Discovery of new markers of cancer through serial analysis of gene expression: prostate stem cell antigen is overexpressed in pancreatic adenocarcinoma publication-title: Cancer Res – volume: 969 start-page: 27 year: 2003 end-page: 35 article-title: Immunocytochemical localization of prostaglandin F synthase II in the rat spinal cord publication-title: Brain Res – volume: 128 start-page: 1117 year: 1982 end-page: 21 article-title: Human renal cell carcinoma: establishment and characterization of two new cell lines publication-title: J Urol – volume: 183 start-page: 2355 year: 1996 end-page: 60 article-title: Protection from anti‐TCR/CD3‐induced apoptosis in immature thymocytes by a signal through thymic shared antigen‐1/stem cell antigen‐2 publication-title: J Exp Med – volume: 275 start-page: 783 year: 2000 end-page: 8 article-title: Reduced expression of PSCA, a member of the LY‐6 family of cell surface antigens in bladder, esophagus and stomach tumors publication-title: Biochem Biophys Res Commun – ident: e_1_2_7_10_2 doi: 10.1158/1078-0432.CCR-04-1842 – ident: e_1_2_7_7_2 doi: 10.1016/S0165-2478(96)02682-X – ident: e_1_2_7_19_2 doi: 10.1073/pnas.95.4.1735 – volume: 61 start-page: 4320 year: 2001 ident: e_1_2_7_13_2 article-title: Discovery of new markers of cancer through serial analysis of gene expression: prostate stem cell antigen is overexpressed in pancreatic adenocarcinoma publication-title: Cancer Res – ident: e_1_2_7_17_2 doi: 10.1002/cne.20760 – ident: e_1_2_7_20_2 doi: 10.1006/bbrc.2000.3393 – ident: e_1_2_7_25_2 doi: 10.1084/jem.183.5.2355 – volume: 61 start-page: 4660 year: 2001 ident: e_1_2_7_12_2 article-title: Prostate stem cell antigen is overexpressed in human transitional cell carcinoma publication-title: Cancer Res – ident: e_1_2_7_24_2 doi: 10.1016/S0304-3835(01)00497-9 – ident: e_1_2_7_18_2 doi: 10.1111/j.1464-410X.2006.06153.x – volume: 62 start-page: 819 year: 2002 ident: e_1_2_7_21_2 article-title: Relationships and differentially expressed genes among pancreatic cancers examined by large scale analysis of gene expression publication-title: Cancer Res – ident: e_1_2_7_3_2 doi: 10.1007/s11934-002-0010-y – ident: e_1_2_7_22_2 doi: 10.1002/(SICI)1098-2264(200001)27:1<95::AID-GCC12>3.0.CO;2-3 – ident: e_1_2_7_4_2 doi: 10.1016/S0022-5347(05)67889-5 – volume-title: WHO, International Classification of tumours year: 1998 ident: e_1_2_7_2_2 – ident: e_1_2_7_29_2 doi: 10.1083/jcb.129.6.1677 – ident: e_1_2_7_27_2 doi: 10.1073/pnas.92.10.4294 – ident: e_1_2_7_16_2 doi: 10.1016/S0006-8993(02)04244-0 – ident: e_1_2_7_26_2 doi: 10.1016/S0021-9258(19)49841-4 – ident: e_1_2_7_6_2 doi: 10.1016/S0090-4295(01)01601-6 – ident: e_1_2_7_8_2 doi: 10.1038/sj.onc.1203426 – ident: e_1_2_7_9_2 doi: 10.1097/01.ju.0000109982.60619.93 – ident: e_1_2_7_28_2 doi: 10.1002/ijc.2910590517 – ident: e_1_2_7_11_2 doi: 10.1093/jjco/hyh073 – ident: e_1_2_7_23_2 doi: 10.1073/pnas.012574899 – volume-title: The General Rules for Clinical Pathological Studies on Renal Cell Carcinoma year: 1992 ident: e_1_2_7_15_2 – ident: e_1_2_7_5_2 doi: 10.1016/S0090-4295(98)00132-0 – ident: e_1_2_7_14_2 doi: 10.1016/S0022-5347(17)53357-1 |
| SSID | ssj0014665 |
| Score | 2.0828824 |
| Snippet | OBJECTIVES
To analyse the gene expression level of prostate stem cell antigen (PSCA) in human clear cell renal cell carcinoma (CC‐RCC) and its relationship... To analyse the gene expression level of prostate stem cell antigen (PSCA) in human clear cell renal cell carcinoma (CC-RCC) and its relationship with... |
| SourceID | proquest pubmed pascalfrancis crossref wiley |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 668 |
| SubjectTerms | Antigens, Neoplasm Biological and medical sciences Carcinoma, Renal Cell - metabolism Cell Line, Tumor clear cell carcinoma Female Gene Expression GPI-Linked Proteins Humans kidney Kidney Neoplasms - metabolism Kidneys Male Medical sciences Membrane Glycoproteins - metabolism Middle Aged Neoplasm Proteins - metabolism Nephrology. Urinary tract diseases Prognosis PSCA real‐time RT‐PCR Reverse Transcriptase Polymerase Chain Reaction - methods Tumors of the urinary system |
| Title | The expression of prostate stem cell antigen in human clear cell renal cell carcinoma: a quantitative reverse transcriptase‐polymerase chain reaction analysis |
| URI | https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fj.1464-410X.2006.06350.x https://www.ncbi.nlm.nih.gov/pubmed/16925770 https://www.proquest.com/docview/68778630 |
| Volume | 98 |
| WOSCitedRecordID | wos000240199500039&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVWIB databaseName: Wiley Online Library - Journals customDbUrl: eissn: 1464-410X dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0014665 issn: 1464-4096 databaseCode: DRFUL dateStart: 19990101 isFulltext: true titleUrlDefault: https://onlinelibrary.wiley.com providerName: Wiley-Blackwell |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3NTuMwELb4E0JCsMACZaHrA9egBLuOyw12t0KIrVarrdRbZLuOQGKT0rQIbjwCj8Cz8STM2GmroB4Q4hbJGqfNzHg-_30fIYdMQZ2zzMDcJG4EXAsZyKbuBaEyaBBrrlInNhG327Lbbf4pzz_hXRjPDzFZcMPMcOM1JrjSxdsk5wGPwm65pwC1MzwCPLmId6xgIrb482-rcznZU-DCCUt6K0Du1XM9M_uqFKvVvirgu6Ve8GIWIq0CXFehWuuf-d--kLUSp9JTH1gbZM5mm2T5d7kTv0WeIb6ovS-P0WY0T2kfL5AAdKXIDU1xR4CC25Dtk15n1IkBUoMqFb5tYPEF7tGgoFGW_1cnVNHbEVoNHSE5RYKpQWHpEEuqG-Cg6r48PvXzmwdcToMmc6Wge8C-7oYGvNKzrHwlndavfz_Og1LtITBcsDDo9RpRqiLbSCPjeO41D5mOmIhgHARYYpAwAdltZGp7QmIwcSW0RQYlxZhh22QhyzO7C26FAJQpB-TFDYfupBTqWAqhDdNMa1Yj8ditiSmp0FGR4yapTIl4gg5AoU6ROAck9zUSTSz7ng7kHTb1SuRMDSUArOZxXCPfx6GUQHLjh1eZzUdFIiTS-7GwRnZ8hE1tRRMG2xhahAukd_-a5Oyig097HzX8Rlb8MhSes9snC8PByB6QJXM3vC4GdTIfd2W9TL1XPSYuYg |
| linkProvider | Wiley-Blackwell |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3JThwxEC1FQ5QgoezAZAEfcu2oG3vcntzIMiLJMIoiRpqbZXvcChJ0D7MguPEJ-QS-jS-hym4GdcQBRbm1ZJV7qSrXay_vAbznBuuc5w7_TfJOIqxUieracZIaRwa5FaYIYhP5YKBGo-7PWg6IzsJEfojlhBtlRhivKcFpQvrvLBeJyNJRvaiAxTP9gIByRUieqxasfPnVG_aXiwpCBmXJaIXQvbmx586-GtVqbWJm-OGKqHhxFyRtItxQonpP_-vLPYMnNVJluzG0nsMDX76AR_v1WvxLuMQIY_6s3khbsqpgEzpCguCVETs0ozUBho4jvk92WLIgB8gc6VTEtqmnG4RLR5JGZXVsPjLDThZkNQ-U5IwopqYzz-ZUVMMQh3X36uLPpDo6pwk1bHK_DXaP6Dec0cBbRp6VVzDsfT34vJfUeg-JQ4elyXjcyQqT-U6RucB0b0XKbcZlhiMhAhNHlAnEb6MKP5aKwkkYaT1xKBnOHV-HVlmVfhP9iiGoCoHYSziB3SklzY6S0jpuubW8DfmNX7WrydBJk-NIN36KhCYHkFSn1MEB-qwN2dJyEglB7mGz1QidW0OFEKu7k7dh-yaWNKY3fXhT-mox01IRwR9P27ARQ-zWVnZxuM2xRYZIuvfT6E_fh3T1-l8Nt-Hx3sF-X_e_DX68gdU4KUW77t5Caz5d-Hfw0J3OD2fTrToDrwE0HzFq |
| linkToPdf | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3bbtQwEB2hLaqQEPfLcmn9wGtQUjuOwxtQVlzKqkKstG-W7ThqpZKEvaDyxifwCXwbX8KMnW4V1IcK8RbJGucyM54TX84BeMYN1jnPHf6bFHkirFSJKm2VpMaRQWGFqYPYRDGdqvm8POzlgOgsTOSH2Ey4UWaE8ZoS3HdV_XeWi0Rk6bxfVMDimT5HQLkl8jIXI9ja_zSZHWwWFYQMypLRCqH7cGPPhX0NqtX1zizxw9VR8eIiSDpEuKFETW7-15e7BTd6pMpextC6DVd8cwe2P_Zr8XfhF0YY86f9RtqGtTXr6AgJgldG7NCM1gQYOo74Ptlxw4IcIHOkUxHbFp5uEC4dSRo17Rfzghn2dU1Wq0BJzohiarH0bEVFNQxxWHd___jZtSffaUINm9yRwe4R_YYzGnjLyLNyD2aTN59fv016vYfECcnTpKryrDaZz-vMBaZ7K1JuMy4zHAkRmDiiTCB-G1X7SioKJ2Gk9cShZDh3_D6MmrbxD9GvGIKqFoi9hBPYnVLS7CkpreOWW8vHUJz5VbueDJ00OU704KdIaHIASXVKHRygT8eQbSy7SAhyCZudQeicGyqEWOVeMYbds1jSmN704U3j2_VSS0UEfzwdw4MYYue2ssThtsAWGSLp0k-jX72f0dWjfzXche3D_Yk-eDf98BiuxTkp2nT3BEarxdo_havu2-p4udjpE_APdqYw5Q |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+expression+of+prostate+stem+cell+antigen+in+human+clear+cell+renal+cell+carcinoma%3A+a+quantitative+reverse+transcriptase-polymerase+chain+reaction+analysis&rft.jtitle=BJU+international&rft.au=Elsamman%2C+Essam+M&rft.au=Fukumori%2C+Tomoharu&rft.au=Tanimoto%2C+Shuji&rft.au=Nakanishi%2C+Ryoichi&rft.date=2006-09-01&rft.issn=1464-4096&rft.volume=98&rft.issue=3&rft.spage=668&rft_id=info:doi/10.1111%2Fj.1464-410X.2006.06350.x&rft_id=info%3Apmid%2F16925770&rft.externalDocID=16925770 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1464-4096&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1464-4096&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1464-4096&client=summon |