Pathogenesis of non-alcoholic fatty liver disease in children and adolescence: From "two hit theory" to "multiple hit model"

Nonalcoholic fatty liver disease (NAFLD) has become the dominant form of chronic liver disease in children and adolescents with the increasing prevalence of obesity worldwide. NAFLD represents a wide spectrum of conditions, ranging from fatty liver - which generally follows a benign, non-progressive...

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Bibliographic Details
Published in:World journal of gastroenterology : WJG Vol. 24; no. 27; p. 2974
Main Authors: Fang, Yan-Lan, Chen, Hong, Wang, Chun-Lin, Liang, Li
Format: Journal Article
Language:English
Published: United States 21.07.2018
Subjects:
Nonalcoholic fatty liver disease
Children
Adolescents
Non-alcoholic steatohepatitis
Pathogenesis
ISSN:2219-2840, 2219-2840
Online Access:Get more information
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Summary:Nonalcoholic fatty liver disease (NAFLD) has become the dominant form of chronic liver disease in children and adolescents with the increasing prevalence of obesity worldwide. NAFLD represents a wide spectrum of conditions, ranging from fatty liver - which generally follows a benign, non-progressive clinical course - to non-alcoholic steatohepatitis, a subset of NAFLD that may progress to cirrhosis and end-stage liver disease or liver carcinoma. The underlying pathophysiological mechanism of "pediatric" NAFLD remains unclear, although it is strongly associated with obesity and insulin resistance. In this review we provide a general overview on the current understanding of NAFLD in children and adolescents, which underpins practice, enabling early diagnosis and appropriate therapeutic intervention for this life-threatening liver disease.
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ISSN:2219-2840
2219-2840
DOI:10.3748/wjg.v24.i27.2974