Clinical impact and direct costs of nosocomial respiratory syncytial virus infections in the neonatal intensive care unit

•Nosocomial viral infections are frequently overlooked in neonatology units.•Nosocomial respiratory syncytial virus infection resulted in longer hospitalizations.•Health-care interventions increased in infants with nosocomial infection.•Hospital costs were higher in infants with respiratory syncytia...

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Veröffentlicht in:American journal of infection control Jg. 48; H. 9; S. 982 - 986
Hauptverfasser: Comas-García, Andreu, Aguilera-Martínez, José I., Escalante-Padrón, Francisco J., Lima-Rogel, Victoria, Gutierrez-Mendoza, Luis M., Noyola, Daniel E.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States Elsevier Inc 01.09.2020
Schlagworte:
Economics
Health-care associated infection
Infectious Disease
Newborn
Pneumonia
Premature
Economics
Premature
Health-care associated infection
Pneumonia
Newborn
ISSN:0196-6553, 1527-3296, 1527-3296
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Zusammenfassung:•Nosocomial viral infections are frequently overlooked in neonatology units.•Nosocomial respiratory syncytial virus infection resulted in longer hospitalizations.•Health-care interventions increased in infants with nosocomial infection.•Hospital costs were higher in infants with respiratory syncytial virus infection.•Interventions to reduce nosocomial respiratory syncytial virus infections are needed. Nosocomial infections are a leading cause of morbidity, costs, and mortality in preterm newborns. Most reports regarding nosocomial infections in neonatal intensive care units (NICU) are focused on bacterial infections and there is limited information regarding the impact of nosocomial viruses. The objective of this study was to assess the impact of nosocomial respiratory syncytial virus (RSV) infections in a NICU. This was a retrospective cohort design from a NICU in a general hospital in Mexico. We included 24 newborn infants with nosocomial RSV infection and 24 infants without RSV matched by gestational age, birth weight, and the period of time of hospitalization. Infants with nosocomial RSV infection had longer hospitalization duration (median 24 days vs. 13 days; P = .05), increased antibiotic use (45.8% vs. 8.3%; P = .003), more mechanical ventilation requirement (54.2% vs. 0.4%; P <.001), more frequent nosocomial infections (45.8% vs. 0%; P <.001), and higher hospitalization direct costs (median 3,587.20 USD vs. 1,123.60 USD; P = .001) after nosocomial RSV detection. Nosocomial RSV infections are associated to a significant increase of costs in infants hospitalized in the NICU. Evaluation of interventions that may reduce the incidence of nosocomial RSV infections in this setting is warranted.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0196-6553
1527-3296
1527-3296
DOI:10.1016/j.ajic.2020.04.009