Current State of Clinical Trials and Regulatory Approvals with Fibroblast Activation Protein Targeting Interventions

In this article, the authors review the current state of fibroblast activation protein (FAP)-targeted interventions utilizing available data from clinicaltrials.gov. Thirty-seven records were reviewed and demonstrated interventions with imaging studies comprising the largest portion of the active st...

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Bibliographic Details
Published in:PET clinics Vol. 18; no. 3; p. 429
Main Authors: Mosessian, Sherly, Jensen, Jessica D, Enke, Aaron S
Format: Journal Article
Language:English
Published: United States 01.07.2023
Subjects:
Diagnostic Imaging
Fibroblasts - metabolism
Humans
Cancer-associated fibroblasts
Clinical development
Theranostic
Clinical trial
Diagnostic
Radioligand therapy
Radiopharmaceuticals
Fibroblast activation protein
ISSN:1879-9809, 1879-9809
Online Access:Get more information
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Summary:In this article, the authors review the current state of fibroblast activation protein (FAP)-targeted interventions utilizing available data from clinicaltrials.gov. Thirty-seven records were reviewed and demonstrated interventions with imaging studies comprising the largest portion of the active studies in progress, followed by therapeutic studies using non-radioligand and radioligand therapy. The efforts are in early stages of clinical development; however the field is gaining significant momentum. Completion of existing clincial studies and entrance of new products into the clincial trial phase will shed important light on the clinical utility of these interventions and shape future clinical development efforts.
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ISSN:1879-9809
1879-9809
DOI:10.1016/j.cpet.2023.02.010