Efficient and flexible simulation-based sample size determination for clinical trials with multiple design parameters

Simulation offers a simple and flexible way to estimate the power of a clinical trial when analytic formulae are not available. The computational burden of using simulation has, however, restricted its application to only the simplest of sample size determination problems, often minimising a single...

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Bibliographic Details

Published in:	Statistical methods in medical research Vol. 30; no. 3; p. 799
Main Authors:	Wilson, Duncan T, Hooper, Richard, Brown, Julia, Farrin, Amanda J, Walwyn, Rebecca Ea
Format:	Journal Article
Language:	English
Published:	England 01.03.2021
Subjects:	Algorithms Cluster Analysis Computer Simulation Models, Statistical Research Design Sample Size Clinical trials Gaussian process global optimisation power sample size simulation
ISSN:	1477-0334, 1477-0334
Online Access:	Get more information
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