Subclinical hypothyroidism, lipid metabolism and cardiovascular disease
Subclinical hypothyroidism is defined by elevated serum thyrotropin in presence of normal free thyroid hormones. Lipid metabolism is influenced by thyroid hormone and many reports showed that lipids status worsen along with TSH level. Subclinical hypothyroidism has been also linked to other cardiova...
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| Vydané v: | European journal of internal medicine Ročník 38; s. 17 - 24 |
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| Hlavní autori: | , , , |
| Médium: | Journal Article |
| Jazyk: | English |
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Netherlands
Elsevier B.V
01.03.2017
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| ISSN: | 0953-6205, 1879-0828, 1879-0828 |
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| Abstract | Subclinical hypothyroidism is defined by elevated serum thyrotropin in presence of normal free thyroid hormones. Lipid metabolism is influenced by thyroid hormone and many reports showed that lipids status worsen along with TSH level. Subclinical hypothyroidism has been also linked to other cardiovascular risk factors such as alteration in blood pressure and increased atherosclerosis. Further evidences suggested that mild dysfunction of thyroid gland is associated with metabolic syndrome and heart failure. Thyrotropin level seems the best predictor of cardiovascular disease, in particular when its levels are above 10mU/L. However, despite these observations, there is no clear evidence that levothyroxine therapy in subjects with milder form of subclinical hypothyroidism could improve lipid status and the other cardiovascular risk factors. In this review, we address the effect of thyroid hormone and cardiovascular risk, with a focus on lipid metabolism.
•Thyroid hormones regulates lipid metabolism.•Subclinical hypothyroidism could worsen lipid status.•The beneficial effect of levo-thyroxine substitute therapy on lipids require further studies. |
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| AbstractList | Subclinical hypothyroidism is defined by elevated serum thyrotropin in presence of normal free thyroid hormones. Lipid metabolism is influenced by thyroid hormone and many reports showed that lipids status worsen along with TSH level. Subclinical hypothyroidism has been also linked to other cardiovascular risk factors such as alteration in blood pressure and increased atherosclerosis. Further evidences suggested that mild dysfunction of thyroid gland is associated with metabolic syndrome and heart failure. Thyrotropin level seems the best predictor of cardiovascular disease, in particular when its levels are above 10mU/L. However, despite these observations, there is no clear evidence that levothyroxine therapy in subjects with milder form of subclinical hypothyroidism could improve lipid status and the other cardiovascular risk factors. In this review, we address the effect of thyroid hormone and cardiovascular risk, with a focus on lipid metabolism.
•Thyroid hormones regulates lipid metabolism.•Subclinical hypothyroidism could worsen lipid status.•The beneficial effect of levo-thyroxine substitute therapy on lipids require further studies. Abstract Subclinical hypothyroidism is defined by elevated serum thyrotropin in presence of normal free thyroid hormones. Lipid metabolism is influenced by thyroid hormone and many reports showed that lipids status worsen along with TSH level. Subclinical hypothyroidism has been also linked to other cardiovascular risk factors such as alteration in blood pressure and increased atherosclerosis. Further evidences suggested that mild dysfunction of thyroid gland is associated with metabolic syndrome and heart failure. Thyrotropin level seems the best predictor of cardiovascular disease, in particular when its levels are above 10 mU/L. However, despite these observations, there is no clear evidence that levothyroxine therapy in subjects with milder form of subclinical hypothyroidism could improve lipid status and the other cardiovascular risk factors. In this review, we address the effect of thyroid hormone and cardiovascular risk, with a focus on lipid metabolism. Subclinical hypothyroidism is defined by elevated serum thyrotropin in presence of normal free thyroid hormones. Lipid metabolism is influenced by thyroid hormone and many reports showed that lipids status worsen along with TSH level. Subclinical hypothyroidism has been also linked to other cardiovascular risk factors such as alteration in blood pressure and increased atherosclerosis. Further evidences suggested that mild dysfunction of thyroid gland is associated with metabolic syndrome and heart failure. Thyrotropin level seems the best predictor of cardiovascular disease, in particular when its levels are above 10mU/L. However, despite these observations, there is no clear evidence that levothyroxine therapy in subjects with milder form of subclinical hypothyroidism could improve lipid status and the other cardiovascular risk factors. In this review, we address the effect of thyroid hormone and cardiovascular risk, with a focus on lipid metabolism.Subclinical hypothyroidism is defined by elevated serum thyrotropin in presence of normal free thyroid hormones. Lipid metabolism is influenced by thyroid hormone and many reports showed that lipids status worsen along with TSH level. Subclinical hypothyroidism has been also linked to other cardiovascular risk factors such as alteration in blood pressure and increased atherosclerosis. Further evidences suggested that mild dysfunction of thyroid gland is associated with metabolic syndrome and heart failure. Thyrotropin level seems the best predictor of cardiovascular disease, in particular when its levels are above 10mU/L. However, despite these observations, there is no clear evidence that levothyroxine therapy in subjects with milder form of subclinical hypothyroidism could improve lipid status and the other cardiovascular risk factors. In this review, we address the effect of thyroid hormone and cardiovascular risk, with a focus on lipid metabolism. Subclinical hypothyroidism is defined by elevated serum thyrotropin in presence of normal free thyroid hormones. Lipid metabolism is influenced by thyroid hormone and many reports showed that lipids status worsen along with TSH level. Subclinical hypothyroidism has been also linked to other cardiovascular risk factors such as alteration in blood pressure and increased atherosclerosis. Further evidences suggested that mild dysfunction of thyroid gland is associated with metabolic syndrome and heart failure. Thyrotropin level seems the best predictor of cardiovascular disease, in particular when its levels are above 10mU/L. However, despite these observations, there is no clear evidence that levothyroxine therapy in subjects with milder form of subclinical hypothyroidism could improve lipid status and the other cardiovascular risk factors. In this review, we address the effect of thyroid hormone and cardiovascular risk, with a focus on lipid metabolism. |
| Author | Delitala, Giuseppe Maioli, Margherita Delitala, Alessandro P Fanciulli, Giuseppe |
| Author_xml | – sequence: 1 givenname: Alessandro P orcidid: 0000-0003-1729-8969 surname: Delitala fullname: Delitala, Alessandro P email: aledelitala@tiscali.it organization: Clinica Medica, Azienda Ospedaliero Universitaria di Sassari, Viale San Pietro 8, 07100, Sassari, Italy – sequence: 2 givenname: Giuseppe surname: Fanciulli fullname: Fanciulli, Giuseppe organization: Department of Clinical and Experimental Medicine, University of Sassari – Azienda Ospedaliero Universitaria di Sassari, Viale San Pietro 8, 07100 Sassari, Italy – sequence: 3 givenname: Margherita surname: Maioli fullname: Maioli, Margherita organization: Center for developmental biology and reprogramming - CEDEBIOR, Department of Biomedical Sciences, University of Sassari, Viale San Pietro 43/B, 07100 Sassari, Italy – sequence: 4 givenname: Giuseppe surname: Delitala fullname: Delitala, Giuseppe organization: Department of Clinical and Experimental Medicine, University of Sassari – Azienda Ospedaliero Universitaria di Sassari, Viale San Pietro 8, 07100 Sassari, Italy |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/28040402$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1111/cen.12532 10.1016/S0021-9150(02)00372-6 10.1161/01.CIR.100.2.123 10.1111/jgs.13532 10.1111/j.1365-2796.2006.01652.x 10.1210/jc.2006-1605 10.1007/BF02598988 10.1186/1476-511X-11-17 10.1089/thy.2000.10.251 10.1016/j.bbagen.2012.06.003 10.1210/jc.2003-030039 10.1530/eje.1.01857 10.1074/jbc.M305417200 10.1210/jcem.86.10.7973 10.1089/thy.2014.0219 10.1089/thy.2000.10.803 10.1016/j.atherosclerosis.2008.09.022 10.1507/endocrj.43.731 10.7326/0003-4819-148-11-200806030-00225 10.1016/j.metabol.2009.08.018 10.1210/jc.2012-1133 10.1016/S0002-9343(02)01022-7 10.1210/jc.2013-1315 10.1507/endocrj.K09E-315 10.4158/EP.14.5.570 10.1089/thy.2012.0013 10.1056/NEJM193012252032601 10.1210/jcem.87.4.8378 10.1016/0026-0495(95)90075-6 10.4158/EP.12.1.5 10.1111/j.1365-2265.2005.02399.x 10.1038/324641a0 10.1177/000331970305400506 10.1159/000356507 10.1111/j.1365-2265.2007.02943.x 10.1253/circj.71.191 10.1186/1743-7075-9-44 10.1507/endocrj.EJ12-0226 10.1111/cen.12216 10.1016/j.maturitas.2016.07.003 10.1007/s11886-004-0054-3 10.1001/jama.291.2.228 10.1089/105072503321669857 10.1016/S0009-8981(98)00074-6 10.1210/jc.2008-0167 10.1002/14651858.CD003419.pub2 10.1210/en.2006-0116 10.1016/j.amjmed.2005.09.028 10.1007/BF03347530 10.1210/jc.2014-3586 10.1159/000362597 10.1210/jc.2012-4065 10.1210/jcem.86.2.7221 10.1210/jc.2015-3191 10.1016/j.atherosclerosis.2008.06.011 10.1530/acta.0.1280202 10.1210/jc.2012-3818 10.1111/j.1365-2265.2008.03509.x 10.1001/jama.1972.03200070084015 10.1016/j.amjmed.2004.04.027 10.1007/s12020-011-9446-5 10.1002/hep.23800 10.1016/j.tem.2009.11.004 10.1089/thy.2007.0165 10.1210/jc.2011-2532 10.1210/jc.2003-030398 10.1089/thy.2010.0313 10.1089/thy.2006.0302 10.1210/me.2002-0009 10.1016/0009-9120(96)00069-0 10.1089/thy.2007.0359 10.1089/thy.2006.0208 10.1210/er.2006-0043 10.1016/j.metabol.2004.05.016 10.1016/S2213-8587(14)70006-3 10.1210/jc.2002-020493 10.17219/acem/38555 10.5455/medarh.2012.66.364-368 10.1210/jcem.87.7.8678 10.1210/jc.2004-2225 10.1001/jama.295.9.1033 10.3904/kjim.2011.26.4.432 10.1056/NEJMoa0905633 10.1111/j.1440-1681.1998.tb02293.x 10.1001/jama.2010.1361 10.1210/endo-125-1-459 10.1053/j.gastro.2008.01.032 10.1089/thy.2016.0010 10.2169/internalmedicine.33.413 10.1210/jc.2012-2180 10.1016/j.numecd.2015.09.001 10.1210/jc.2003-031669 10.1111/j.1365-2265.2004.02088.x 10.1111/ijcp.12394 10.1016/j.trsl.2007.12.006 10.1530/eje.0.1450705 10.1530/EJE-14-0182 10.1001/archinte.1990.00390210077017 |
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| Copyright | 2016 European Federation of Internal Medicine European Federation of Internal Medicine Copyright © 2016 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved. |
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| Keywords | FT3 LDL-C FT4 SREBP-2 TSH HMG-CoA Cardiovascular disease LT4 Lp(a) TC CVD HDL-C IMT TG LDL-R Subclinical hypothyroidism Cardiovascular risk SCH Lipid metabolism CHD TR BMI hydroxymethylglutaryl coenzyme A reductase sterol regulatory element-binding protein-2 intima media thickness low density lipoprotein receptor total cholesterol lipoprotein (a) thyrotropin thyroid hormone receptor free thyroxine subclinical hypothyroidism cardiovascular disease body mass index free triiodothyronine triglycerides high density lipoprotein cholesterol levothyroxine coronary heart disease low density lipoprotein cholesterol |
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| References | Wang, Tan, Wang, Zhang, Zhao, Song (bb0280) 2012; 97 Kong, Sheikh, Lumb, Naoumova, Freedman, Crook (bb0470) 2002; 112 Fadeyev, Sytch, Kalashnikov, Rojtman, Syrkin, Melnichenko (bb0430) 2006; 12 Tagami, Tamanaha, Shimazu, Honda, Nanba, Nomura (bb0405) 2010; 57 Lee, Kim, Oh, Park, Kim, Park (bb0065) 2011; 26 Mikhail, Alshammari, Alenezi, Mansour, Khalil (bb0415) 2008; 14 Hennessey, Espaillat (bb0125) 2015; 63 Iqbal, Jorde, Figenschau (bb0425) 2006; 260 Xu, Yang, Liu, Yuan, Yu, Gao (bb0270) 2012; 9 Delitala, Pilia, Ferreli, Loi, Curreli, Balaci (bb0020) 2014; 171 Delitala, Orru, Filigheddu, Pilia, Delitala, Ganau (bb0135) 2015; 82 Pedersen, Aardal, Larssen, Varhaug, Myking, Vik-Mo (bb0035) 2000; 10 Tognini, Polini, Pasqualetti, Ursino, Caraccio, Ferdeghini (bb0275) 2012; 22 Santos-Palacios, Brugos-Larumbe, Guillen-Grima, Galofre (bb0285) 2013; 79 Waterhouse, McLaughlin, Walsh, Sheehan, O'Shea (bb0240) 2007; 17 Serter, Demirbas, Korukluoglu, Culha, Cakal, Aral (bb0435) 2004; 27 Cappola, Fried, Arnold, Danese, Kuller, Burke (bb0265) 2006; 295 Takashima, Niwa, Mannami, Tomoike, Iwai (bb0160) 2007; 71 Takamura, Akilzhanova, Hayashida, Kadota, Yamasaki, Usa (bb0145) 2009; 204 Milionis, Efstathiadou, Tselepis, Bairaktari, Tsironis, Tsatsoulis (bb0465) 2003; 13 Dullaart, de Vries, Roozendaal, Kobold, Sluiter (bb0150) 2007; 67 Jorde, Joakimsen, Stensland, Mathiesen (bb0155) 2008; 18 Chiche, Jublanc, Coudert, Carreau, Kahn, Bruckert (bb0170) 2009; 203 Arem, Patsch (bb0505) 1990; 150 Ito, Takamatsu, Sasaki, Hiraiwa, Fukao, Murakami (bb0230) 2004; 117 Hashimoto, Yamada, Matsumoto, Monden, Satoh, Mori (bb0340) 2006; 147 Schreier, Sanguinetti, Mosso, Lopez, Siri, Wikinski (bb0195) 1996; 29 Knudsen, Laurberg, Rasmussen, Bulow, Perrild, Ovesen (bb0045) 2005; 90 Taylor, Razvi, Pearce, Dayan (bb0050) 2013; 98 Pearce (bb0185) 2004; 6 Bilic-Komarica, Beciragic, Junuzovic (bb0380) 2012; 66 Brenta, Berg, Arias, Zago, Schnitman, Muzzio (bb0225) 2007; 17 Caraccio, Ferrannini, Monzani (bb0140) 2002; 87 Adamarczuk-Janczyszyn, Zdrojowy-Welna, Rogala, Zatonska, Bednarek-Tupikowska (bb0365) 2016; 25 Monzani, Caraccio, Kozakowa, Dardano, Vittone, Virdis (bb0450) 2004; 89 Pearce, Brabant, Duntas, Monzani, Peeters, Razvi (bb0025) 2013; 2 Gagnon, Antunes, Ly, Pongsuwan, Gavin, Lochnan (bb0250) 2010; 59 Paoli, Bellabarba, Velazquez, Mendoza, Molina, Wang (bb0480) 1998; 275 Apriletti, Ribeiro, Wagner, Feng, Webb, Kushner (bb0320) 1998; 25 Romaldini, Biancalana, Figueiredo, Farah, Mathias (bb0490) 1996; 6 Kowalska, Borawski, Nikolajuk, Budlewski, Otziomek, Gorska (bb0395) 2011; 40 Razvi, Shakoor, Vanderpump, Weaver, Pearce (bb0075) 2008; 93 Christ-Crain, Meier, Guglielmetti, Huber, Riesen, Staub (bb0055) 2003; 166 Arem, Escalante, Arem, Morrisett, Patsch (bb0495) 1995; 44 Rodondi, Aujesky, Vittinghoff, Cornuz, Bauer (bb0260) 2006; 119 Obuobie, Smith, Evans, John, Davies, Lazarus (bb0130) 2002; 87 Galioni, Gofman, Guzvich, Pouteau, Rubinger, Strisower (bb0300) 1957; 272 Anagnostis, Efstathiadou, Slavakis, Selalmatzidou, Poulasouchidou, Katergari (bb0375) 2014; 68 Chadarevian, Bruckert, Leenhardt, Giral, Ankri, Turpin (bb0060) 2001; 86 Delitala, Steri, Pilia, Dei, Lai, Delitala (bb0290) 2016; 92 Tian, Song, Xing, Zhang, Ning, Li (bb0255) 2010; 52 Jaeschke, Guyatt, Gerstein, Patterson, Molloy, Cook (bb0510) 1996; 11 Hyland, Arnold, Lee, Cappola (bb0100) 2013; 98 Miura, Iitaka, Yoshimura, Kitahama, Fukasawa, Kawakami (bb0515) 1994; 33 Sigal, Medeiros-Neto, Vinagre, Diament, Maranhao (bb0400) 2011; 21 Ganotakis, Mandalaki, Tampakaki, Malliaraki, Mandalakis, Vrentzos (bb0455) 2003; 54 Taddei, Caraccio, Virdis, Dardano, Versari, Ghiadoni (bb0460) 2003; 88 Cappola, Ladenson (bb0095) 2003; 88 Galman, Bonde, Matasconi, Angelin, Rudling (bb0345) 2008; 134 Ito, Kitanaka, Arishima, Kudo, Nishihara, Kubota (bb0385) 2013; 60 Zhao, Liu, Wang, Yuan, Zhang, Xu (bb0370) 2016; 26 Adrees, Gibney, El-Saeity, Boran (bb0215) 2009; 71 Delitala, Filigheddu, Orru, AlGhatrif, Steri, Pilia (bb0165) 2015; 25 Rodondi, den Elzen, Bauer, Cappola, Razvi, Walsh (bb0110) 2010; 304 Ochs, Auer, Bauer, Nanchen, Gussekloo, Cornuz (bb0080) 2008; 148 Shin, Osborne (bb0180) 2003; 278 Gullu, Sav, Kamel (bb0440) 2005; 152 Flamant, Gauthier (bb0310) 2013; 1830 Villar, Saconato, Valente, Atallah (bb0235) 2007; 3 Bogner, Arntz, Peters, Schleusener (bb0500) 1993; 128 Liu, Brent (bb0010) 2010; 21 Lempiainen, Mykkanen, Pyorala, Laakso, Kuusisto (bb0200) 1999; 100 Tzotzas, Krassas, Konstantinidis, Bougoulia (bb0220) 2000; 10 Meier, Staub, Roth, Guglielmetti, Kunz, Miserez (bb0475) 2001; 86 Peleg, Efrati, Benbassat, Fygenzo, Golik (bb0410) 2008; 18 Sjouke, Langslet, Ceska, Nicholls, Nissen, Ohlander (bb0350) 2014; 2 Day, Gebhard, Schwartz, Strait, Duane, Stone (bb0330) 1989; 125 Steinberg, Parthasarathy, Carew, Khoo, Witztum (bb0190) 1989; 320 Mason, Hunt, Hurxthal (bb0295) 1930; 203 Huber, Staub, Meier, Mitrache, Guglielmetti, Huber (bb0040) 2002; 87 Cabral, Teixeira, Soares, Leite, Salles, Waisman (bb0390) 2011; 66 Zhao, Yang, Chen, Tang, Guan, Zhang (bb0115) 2015; 25 Pearce (bb0175) 2012; 97 Pasqualetti, Tognini, Polini, Caraccio, Monzani (bb0120) 2013; 98 Efstathiadou, Bitsis, Milionis, Kukuvitis, Bairaktari, Elisaf (bb0210) 2001; 145 Ito, Arishima, Kudo, Nishihara, Ohye, Kubota (bb0420) 2007; 92 Lazarus, Brown, Daumerie, Hubalewska-Dydejczyk, Negro, Vaidya (bb0030) 2014; 3 Ladenson, Kristensen, Ridgway, Olsson, Carlsson, Klein (bb0325) 2010; 362 Cappola, Arnold, Wulczyn, Carlson, Robbins, Psaty (bb0355) 2015; 100 Surks, Ortiz, Daniels, Sawin, Col, Cobin (bb0015) 2004; 291 Yildirimkaya, Ozata, Yilmaz, Kilinc, Gundogan, Kutluay (bb0485) 1996; 43 Kvetny, Heldgaard, Bladbjerg, Gram (bb0085) 2004; 61 Walsh, Bremner, Bulsara, O'Leary, Leedman, Feddema (bb0090) 2005; 63 Lu, Guan, Liu, Wang, Xu, Li (bb0245) 2012; 11 Weinberger, Thompson, Ong, Lebo, Gruol, Evans (bb0315) 1986; 324 Webb (bb0005) 2010; 11 LeGrys, Funk, Lorenz, Giri, Jackson, Manson (bb0105) 2013; 98 Virgini, Rodondi, Cawthon, Harrison, Hoffman, Orwoll (bb0360) 2015; 100 Teixeira Pde, Reuters, Ferreira, Almeida, Reis, Buescu (bb0205) 2008; 151 Biondi, Cooper (bb0070) 2008; 29 (bb0305) 1972; 220 Gullberg, Rudling, Salto, Forrest, Angelin, Vennstrom (bb0335) 2002; 16 Perez, Cubero, Sucunza, Ortega, Arcelus, Rodriguez-Espinosa (bb0445) 2004; 53 Taddei (10.1016/j.ejim.2016.12.015_bb0460) 2003; 88 Surks (10.1016/j.ejim.2016.12.015_bb0015) 2004; 291 Bilic-Komarica (10.1016/j.ejim.2016.12.015_bb0380) 2012; 66 Waterhouse (10.1016/j.ejim.2016.12.015_bb0240) 2007; 17 Sigal (10.1016/j.ejim.2016.12.015_bb0400) 2011; 21 Efstathiadou (10.1016/j.ejim.2016.12.015_bb0210) 2001; 145 Adrees (10.1016/j.ejim.2016.12.015_bb0215) 2009; 71 Milionis (10.1016/j.ejim.2016.12.015_bb0465) 2003; 13 Mikhail (10.1016/j.ejim.2016.12.015_bb0415) 2008; 14 Gullberg (10.1016/j.ejim.2016.12.015_bb0335) 2002; 16 Delitala (10.1016/j.ejim.2016.12.015_bb0135) 2015; 82 LeGrys (10.1016/j.ejim.2016.12.015_bb0105) 2013; 98 Takashima (10.1016/j.ejim.2016.12.015_bb0160) 2007; 71 Miura (10.1016/j.ejim.2016.12.015_bb0515) 1994; 33 Cappola (10.1016/j.ejim.2016.12.015_bb0265) 2006; 295 Ito (10.1016/j.ejim.2016.12.015_bb0420) 2007; 92 Apriletti (10.1016/j.ejim.2016.12.015_bb0320) 1998; 25 Rodondi (10.1016/j.ejim.2016.12.015_bb0110) 2010; 304 Sjouke (10.1016/j.ejim.2016.12.015_bb0350) 2014; 2 Yildirimkaya (10.1016/j.ejim.2016.12.015_bb0485) 1996; 43 (10.1016/j.ejim.2016.12.015_bb0305) 1972; 220 Cabral (10.1016/j.ejim.2016.12.015_bb0390) 2011; 66 Tagami (10.1016/j.ejim.2016.12.015_bb0405) 2010; 57 Taylor (10.1016/j.ejim.2016.12.015_bb0050) 2013; 98 Huber (10.1016/j.ejim.2016.12.015_bb0040) 2002; 87 Perez (10.1016/j.ejim.2016.12.015_bb0445) 2004; 53 Lu (10.1016/j.ejim.2016.12.015_bb0245) 2012; 11 Delitala (10.1016/j.ejim.2016.12.015_bb0165) 2015; 25 Liu (10.1016/j.ejim.2016.12.015_bb0010) 2010; 21 Delitala (10.1016/j.ejim.2016.12.015_bb0290) 2016; 92 Jorde (10.1016/j.ejim.2016.12.015_bb0155) 2008; 18 Delitala (10.1016/j.ejim.2016.12.015_bb0020) 2014; 171 Lee (10.1016/j.ejim.2016.12.015_bb0065) 2011; 26 Arem (10.1016/j.ejim.2016.12.015_bb0505) 1990; 150 Ganotakis (10.1016/j.ejim.2016.12.015_bb0455) 2003; 54 Kvetny (10.1016/j.ejim.2016.12.015_bb0085) 2004; 61 Santos-Palacios (10.1016/j.ejim.2016.12.015_bb0285) 2013; 79 Obuobie (10.1016/j.ejim.2016.12.015_bb0130) 2002; 87 Flamant (10.1016/j.ejim.2016.12.015_bb0310) 2013; 1830 Iqbal (10.1016/j.ejim.2016.12.015_bb0425) 2006; 260 Hashimoto (10.1016/j.ejim.2016.12.015_bb0340) 2006; 147 Virgini (10.1016/j.ejim.2016.12.015_bb0360) 2015; 100 Zhao (10.1016/j.ejim.2016.12.015_bb0115) 2015; 25 Arem (10.1016/j.ejim.2016.12.015_bb0495) 1995; 44 Chiche (10.1016/j.ejim.2016.12.015_bb0170) 2009; 203 Gagnon (10.1016/j.ejim.2016.12.015_bb0250) 2010; 59 Webb (10.1016/j.ejim.2016.12.015_bb0005) 2010; 11 Bogner (10.1016/j.ejim.2016.12.015_bb0500) 1993; 128 Knudsen (10.1016/j.ejim.2016.12.015_bb0045) 2005; 90 Lempiainen (10.1016/j.ejim.2016.12.015_bb0200) 1999; 100 Wang (10.1016/j.ejim.2016.12.015_bb0280) 2012; 97 Paoli (10.1016/j.ejim.2016.12.015_bb0480) 1998; 275 Cappola (10.1016/j.ejim.2016.12.015_bb0355) 2015; 100 Jaeschke (10.1016/j.ejim.2016.12.015_bb0510) 1996; 11 Takamura (10.1016/j.ejim.2016.12.015_bb0145) 2009; 204 Zhao (10.1016/j.ejim.2016.12.015_bb0370) 2016; 26 Galman (10.1016/j.ejim.2016.12.015_bb0345) 2008; 134 Meier (10.1016/j.ejim.2016.12.015_bb0475) 2001; 86 Mason (10.1016/j.ejim.2016.12.015_bb0295) 1930; 203 Shin (10.1016/j.ejim.2016.12.015_bb0180) 2003; 278 Pasqualetti (10.1016/j.ejim.2016.12.015_bb0120) 2013; 98 Schreier (10.1016/j.ejim.2016.12.015_bb0195) 1996; 29 Walsh (10.1016/j.ejim.2016.12.015_bb0090) 2005; 63 Weinberger (10.1016/j.ejim.2016.12.015_bb0315) 1986; 324 Pearce (10.1016/j.ejim.2016.12.015_bb0185) 2004; 6 Rodondi (10.1016/j.ejim.2016.12.015_bb0260) 2006; 119 Lazarus (10.1016/j.ejim.2016.12.015_bb0030) 2014; 3 Tognini (10.1016/j.ejim.2016.12.015_bb0275) 2012; 22 Teixeira Pde (10.1016/j.ejim.2016.12.015_bb0205) 2008; 151 Kowalska (10.1016/j.ejim.2016.12.015_bb0395) 2011; 40 Tian (10.1016/j.ejim.2016.12.015_bb0255) 2010; 52 Fadeyev (10.1016/j.ejim.2016.12.015_bb0430) 2006; 12 Caraccio (10.1016/j.ejim.2016.12.015_bb0140) 2002; 87 Adamarczuk-Janczyszyn (10.1016/j.ejim.2016.12.015_bb0365) 2016; 25 Gullu (10.1016/j.ejim.2016.12.015_bb0440) 2005; 152 Chadarevian (10.1016/j.ejim.2016.12.015_bb0060) 2001; 86 Tzotzas (10.1016/j.ejim.2016.12.015_bb0220) 2000; 10 Dullaart (10.1016/j.ejim.2016.12.015_bb0150) 2007; 67 Anagnostis (10.1016/j.ejim.2016.12.015_bb0375) 2014; 68 Romaldini (10.1016/j.ejim.2016.12.015_bb0490) 1996; 6 Day (10.1016/j.ejim.2016.12.015_bb0330) 1989; 125 Ito (10.1016/j.ejim.2016.12.015_bb0230) 2004; 117 Serter (10.1016/j.ejim.2016.12.015_bb0435) 2004; 27 Cappola (10.1016/j.ejim.2016.12.015_bb0095) 2003; 88 Peleg (10.1016/j.ejim.2016.12.015_bb0410) 2008; 18 Ochs (10.1016/j.ejim.2016.12.015_bb0080) 2008; 148 Xu (10.1016/j.ejim.2016.12.015_bb0270) 2012; 9 Hyland (10.1016/j.ejim.2016.12.015_bb0100) 2013; 98 Brenta (10.1016/j.ejim.2016.12.015_bb0225) 2007; 17 Pearce (10.1016/j.ejim.2016.12.015_bb0025) 2013; 2 Razvi (10.1016/j.ejim.2016.12.015_bb0075) 2008; 93 Hennessey (10.1016/j.ejim.2016.12.015_bb0125) 2015; 63 Galioni (10.1016/j.ejim.2016.12.015_bb0300) 1957; 272 Monzani (10.1016/j.ejim.2016.12.015_bb0450) 2004; 89 Pearce (10.1016/j.ejim.2016.12.015_bb0175) 2012; 97 Steinberg (10.1016/j.ejim.2016.12.015_bb0190) 1989; 320 Christ-Crain (10.1016/j.ejim.2016.12.015_bb0055) 2003; 166 Villar (10.1016/j.ejim.2016.12.015_bb0235) 2007; 3 Pedersen (10.1016/j.ejim.2016.12.015_bb0035) 2000; 10 Kong (10.1016/j.ejim.2016.12.015_bb0470) 2002; 112 Biondi (10.1016/j.ejim.2016.12.015_bb0070) 2008; 29 Ito (10.1016/j.ejim.2016.12.015_bb0385) 2013; 60 Ladenson (10.1016/j.ejim.2016.12.015_bb0325) 2010; 362 |
| References_xml | – volume: 52 start-page: 1401 year: 2010 end-page: 1409 ident: bb0255 article-title: A novel role for thyroid-stimulating hormone: up-regulation of hepatic 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase expression through the cyclic adenosine monophosphate/protein kinase A/cyclic adenosine monophosphate-responsive element binding protein pathway publication-title: Hepatology – volume: 125 start-page: 459 year: 1989 end-page: 468 ident: bb0330 article-title: Time course of hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and messenger ribonucleic acid, biliary lipid secretion, and hepatic cholesterol content in methimazole-treated hypothyroid and hypophysectomized rats after triiodothyronine administration: possible linkage of cholesterol synthesis to biliary secretion publication-title: Endocrinology – volume: 2 start-page: 455 year: 2014 end-page: 463 ident: bb0350 article-title: Eprotirome in patients with familial hypercholesterolaemia (the AKKA trial): a randomised, double-blind, placebo-controlled phase 3 study publication-title: Lancet Diabetes Endocrinol – volume: 87 start-page: 3221 year: 2002 end-page: 3226 ident: bb0040 article-title: Prospective study of the spontaneous course of subclinical hypothyroidism: prognostic value of thyrotropin, thyroid reserve, and thyroid antibodies publication-title: J Clin Endocrinol Metab – volume: 11 start-page: 1135 year: 2010 end-page: 1142 ident: bb0005 article-title: Thyroid hormone receptor and lipid regulation publication-title: Curr Opin Investig Drugs – volume: 33 start-page: 413 year: 1994 end-page: 417 ident: bb0515 article-title: Disturbed lipid metabolism in patients with subclinical hypothyroidism: effect of L-thyroxine therapy publication-title: Intern Med – volume: 150 start-page: 2097 year: 1990 end-page: 2100 ident: bb0505 article-title: Lipoprotein and apolipoprotein levels in subclinical hypothyroidism. Effect of levothyroxine therapy publication-title: Arch Intern Med – volume: 87 start-page: 4662 year: 2002 end-page: 4666 ident: bb0130 article-title: Increased central arterial stiffness in hypothyroidism publication-title: J Clin Endocrinol Metab – volume: 79 start-page: 874 year: 2013 end-page: 881 ident: bb0285 article-title: A cross-sectional study of the association between circulating TSH level and lipid profile in a large Spanish population publication-title: Clin Endocrinol (Oxf) – volume: 134 start-page: 1127 year: 2008 end-page: 1136 ident: bb0345 article-title: Dramatically increased intestinal absorption of cholesterol following hypophysectomy is normalized by thyroid hormone publication-title: Gastroenterology – volume: 21 start-page: 347 year: 2011 end-page: 353 ident: bb0400 article-title: Lipid metabolism in subclinical hypothyroidism: plasma kinetics of triglyceride-rich lipoproteins and lipid transfers to high-density lipoprotein before and after levothyroxine treatment publication-title: Thyroid – volume: 29 start-page: 479 year: 1996 end-page: 487 ident: bb0195 article-title: Low-density lipoprotein composition and oxidability in atherosclerotic cardiovascular disease publication-title: Clin Biochem – volume: 88 start-page: 3731 year: 2003 end-page: 3737 ident: bb0460 article-title: Impaired endothelium-dependent vasodilatation in subclinical hypothyroidism: beneficial effect of levothyroxine therapy publication-title: J Clin Endocrinol Metab – volume: 152 start-page: 355 year: 2005 end-page: 361 ident: bb0440 article-title: Effects of levothyroxine treatment on biochemical and hemostasis parameters in patients with hypothyroidism publication-title: Eur J Endocrinol – volume: 25 start-page: 485 year: 2015 end-page: 493 ident: bb0115 article-title: Subclinical hypothyroidism might worsen the effects of aging on serum lipid profiles: a population-based case-control study publication-title: Thyroid – volume: 119 start-page: 541 year: 2006 end-page: 551 ident: bb0260 article-title: Subclinical hypothyroidism and the risk of coronary heart disease: a meta-analysis publication-title: Am J Med – volume: 63 start-page: 670 year: 2005 end-page: 675 ident: bb0090 article-title: Thyroid dysfunction and serum lipids: a community-based study publication-title: Clin Endocrinol (Oxf) – volume: 272 start-page: 120 year: 1957 end-page: 123 ident: bb0300 article-title: Long-term effect of dried thyroid on serum-lipoprotein and serum-cholesterol levels publication-title: Lancet – volume: 57 start-page: 253 year: 2010 end-page: 258 ident: bb0405 article-title: Lipid profiles in the untreated patients with Hashimoto thyroiditis and the effects of thyroxine treatment on subclinical hypothyroidism with Hashimoto thyroiditis publication-title: Endocr J – volume: 68 start-page: 857 year: 2014 end-page: 863 ident: bb0375 article-title: The effect of L-thyroxine substitution on lipid profile, glucose homeostasis, inflammation and coagulation in patients with subclinical hypothyroidism publication-title: Int J Clin Pract – volume: 112 start-page: 348 year: 2002 end-page: 354 ident: bb0470 article-title: A 6-month randomized trial of thyroxine treatment in women with mild subclinical hypothyroidism publication-title: Am J Med – volume: 18 start-page: 825 year: 2008 end-page: 830 ident: bb0410 article-title: The effect of levothyroxine on arterial stiffness and lipid profile in patients with subclinical hypothyroidism publication-title: Thyroid – volume: 59 start-page: 547 year: 2010 end-page: 553 ident: bb0250 article-title: Thyroid-stimulating hormone stimulates lipolysis in adipocytes in culture and raises serum free fatty acid levels in vivo publication-title: Metabolism – volume: 6 start-page: 451 year: 2004 end-page: 456 ident: bb0185 article-title: Hypothyroidism and dyslipidemia: modern concepts and approaches publication-title: Curr Cardiol Rep – volume: 29 start-page: 76 year: 2008 end-page: 131 ident: bb0070 article-title: The clinical significance of subclinical thyroid dysfunction publication-title: Endocr Rev – volume: 2 start-page: 215 year: 2013 end-page: 228 ident: bb0025 article-title: 2013 ETA guideline: management of Subclinical Hypothyroidism publication-title: Eur Thyroid J – volume: 275 start-page: 81 year: 1998 end-page: 91 ident: bb0480 article-title: Sex steroids, lipids, and lipoprotein cholesterols in women with subclinical and overt hypothyroidism before and after L-thyroxine therapy publication-title: Clin Chim Acta – volume: 89 start-page: 2099 year: 2004 end-page: 2106 ident: bb0450 article-title: Effect of levothyroxine replacement on lipid profile and intima-media thickness in subclinical hypothyroidism: a double-blind, placebo-controlled study publication-title: J Clin Endocrinol Metab – volume: 324 start-page: 641 year: 1986 end-page: 646 ident: bb0315 article-title: The c-erb-A gene encodes a thyroid hormone receptor publication-title: Nature – volume: 171 start-page: 143 year: 2014 end-page: 149 ident: bb0020 article-title: Prevalence of unknown thyroid disorders in a Sardinian cohort publication-title: Eur J Endocrinol – volume: 16 start-page: 1767 year: 2002 end-page: 1777 ident: bb0335 article-title: Requirement for thyroid hormone receptor beta in T3 regulation of cholesterol metabolism in mice publication-title: Mol Endocrinol – volume: 61 start-page: 232 year: 2004 end-page: 238 ident: bb0085 article-title: Subclinical hypothyroidism is associated with a low-grade inflammation, increased triglyceride levels and predicts cardiovascular disease in males below 50 publication-title: Clin Endocrinol (Oxf) – volume: 97 start-page: 326 year: 2012 end-page: 333 ident: bb0175 article-title: Update in lipid alterations in subclinical hypothyroidism publication-title: J Clin Endocrinol Metab – volume: 151 start-page: 224 year: 2008 end-page: 231 ident: bb0205 article-title: Lipid profile in different degrees of hypothyroidism and effects of levothyroxine replacement in mild thyroid failure publication-title: Transl Res – volume: 92 start-page: 30 year: 2016 end-page: 34 ident: bb0290 article-title: Menopause modulates the association between thyrotropin levels and lipid parameters: the SardiNIA study publication-title: Maturitas – volume: 12 start-page: 5 year: 2006 end-page: 17 ident: bb0430 article-title: Levothyroxine replacement therapy in patients with subclinical hypothyroidism and coronary artery disease publication-title: Endocr Pract – volume: 3 start-page: 76 year: 2014 end-page: 94 ident: bb0030 article-title: 2014 European thyroid association guidelines for the management of subclinical hypothyroidism in pregnancy and in children publication-title: Eur Thyroid J – volume: 67 start-page: 668 year: 2007 end-page: 673 ident: bb0150 article-title: Carotid artery intima media thickness is inversely related to serum free thyroxine in euthyroid subjects publication-title: Clin Endocrinol (Oxf) – volume: 88 start-page: 2438 year: 2003 end-page: 2444 ident: bb0095 article-title: Hypothyroidism and atherosclerosis publication-title: J Clin Endocrinol Metab – volume: 10 start-page: 803 year: 2000 end-page: 808 ident: bb0220 article-title: Changes in lipoprotein(a) levels in overt and subclinical hypothyroidism before and during treatment publication-title: Thyroid – volume: 11 start-page: 744 year: 1996 end-page: 749 ident: bb0510 article-title: Does treatment with L-thyroxine influence health status in middle-aged and older adults with subclinical hypothyroidism? publication-title: J Gen Intern Med – volume: 17 start-page: 243 year: 2007 end-page: 248 ident: bb0240 article-title: An examination of the relationship between normal range thyrotropin and cardiovascular risk parameters: a study in healthy women publication-title: Thyroid – volume: 98 start-page: 3562 year: 2013 end-page: 3571 ident: bb0050 article-title: Clinical review: a review of the clinical consequences of variation in thyroid function within the reference range publication-title: J Clin Endocrinol Metab – volume: 25 start-page: S2 year: 1998 end-page: 11 ident: bb0320 article-title: Molecular and structural biology of thyroid hormone receptors publication-title: Clin Exp Pharmacol Physiol Suppl – volume: 13 start-page: 365 year: 2003 end-page: 369 ident: bb0465 article-title: Lipoprotein (a) levels and apolipoprotein (a) isoform size in patients with subclinical hypothyroidism: effect of treatment with levothyroxine publication-title: Thyroid – volume: 291 start-page: 228 year: 2004 end-page: 238 ident: bb0015 article-title: Subclinical thyroid disease: scientific review and guidelines for diagnosis and management publication-title: JAMA – volume: 128 start-page: 202 year: 1993 end-page: 206 ident: bb0500 article-title: Subclinical hypothyroidism and hyperlipoproteinaemia: indiscriminate L-thyroxine treatment not justified publication-title: Acta Endocrinol – volume: 60 start-page: 65 year: 2013 end-page: 71 ident: bb0385 article-title: Effect of publication-title: Endocr J – volume: 98 start-page: 533 year: 2013 end-page: 540 ident: bb0100 article-title: Persistent subclinical hypothyroidism and cardiovascular risk in the elderly: the cardiovascular health study publication-title: J Clin Endocrinol Metab – volume: 304 start-page: 1365 year: 2010 end-page: 1374 ident: bb0110 article-title: Subclinical hypothyroidism and the risk of coronary heart disease and mortality publication-title: JAMA – volume: 43 start-page: 731 year: 1996 end-page: 736 ident: bb0485 article-title: Lipoprotein(a) concentration in subclinical hypothyroidism before and after levo-thyroxine therapy publication-title: Endocr J – volume: 90 start-page: 4019 year: 2005 end-page: 4024 ident: bb0045 article-title: Small differences in thyroid function may be important for body mass index and the occurrence of obesity in the population publication-title: J Clin Endocrinol Metab – volume: 9 start-page: 44 year: 2012 ident: bb0270 article-title: Thyroid stimulating hormone, independent of thyroid hormone, can elevate the serum total cholesterol level in patients with coronary heart disease: a cross-sectional design publication-title: Nutr Metab (Lond) – volume: 362 start-page: 906 year: 2010 end-page: 916 ident: bb0325 article-title: Use of the thyroid hormone analogue eprotirome in statin-treated dyslipidemia publication-title: N Engl J Med – volume: 204 start-page: e77 year: 2009 end-page: e81 ident: bb0145 article-title: Thyroid function is associated with carotid intima-media thickness in euthyroid subjects publication-title: Atherosclerosis – volume: 26 start-page: 1019 year: 2016 end-page: 1029 ident: bb0370 article-title: A worthy finding: decrease in total cholesterol and low-density lipoprotein cholesterol in treated mild subclinical hypothyroidism publication-title: Thyroid – volume: 21 start-page: 166 year: 2010 end-page: 173 ident: bb0010 article-title: Thyroid hormone crosstalk with nuclear receptor signaling in metabolic regulation publication-title: Trends Endocrinol Metab – volume: 97 start-page: 2724 year: 2012 end-page: 2731 ident: bb0280 article-title: Thyroid-stimulating hormone levels within the reference range are associated with serum lipid profiles independent of thyroid hormones publication-title: J Clin Endocrinol Metab – volume: 86 start-page: 732 year: 2001 end-page: 737 ident: bb0060 article-title: Components of the fibrinolytic system are differently altered in moderate and severe hypothyroidism publication-title: J Clin Endocrinol Metab – volume: 320 start-page: 915 year: 1989 end-page: 924 ident: bb0190 article-title: Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity publication-title: N Engl J Med – volume: 278 start-page: 34114 year: 2003 end-page: 34118 ident: bb0180 article-title: Thyroid hormone regulation and cholesterol metabolism are connected through sterol regulatory element-binding protein-2 (SREBP-2) publication-title: J Biol Chem – volume: 66 start-page: 1321 year: 2011 end-page: 1328 ident: bb0390 article-title: Effects of thyroxine replacement on endothelial function and carotid artery intima-media thickness in female patients with mild subclinical hypothyroidism publication-title: Clinics (Sao Paulo) – volume: 117 start-page: 696 year: 2004 end-page: 699 ident: bb0230 article-title: Disturbed metabolism of remnant lipoproteins in patients with subclinical hypothyroidism publication-title: Am J Med – volume: 166 start-page: 379 year: 2003 end-page: 386 ident: bb0055 article-title: Elevated C-reactive protein and homocysteine values: cardiovascular risk factors in hypothyroidism? A cross-sectional and a double-blind, placebo-controlled trial publication-title: Atherosclerosis – volume: 148 start-page: 832 year: 2008 end-page: 845 ident: bb0080 article-title: Meta-analysis: subclinical thyroid dysfunction and the risk for coronary heart disease and mortality publication-title: Ann Intern Med – volume: 203 start-page: 269 year: 2009 end-page: 276 ident: bb0170 article-title: Hypothyroidism is not associated with increased carotid atherosclerosis when cardiovascular risk factors are accounted for in hyperlipidemic patients publication-title: Atherosclerosis – volume: 71 start-page: 191 year: 2007 end-page: 195 ident: bb0160 article-title: Characterization of subclinical thyroid dysfunction from cardiovascular and metabolic viewpoints: the Suita study publication-title: Circ J – volume: 145 start-page: 705 year: 2001 end-page: 710 ident: bb0210 article-title: Lipid profile in subclinical hypothyroidism: is L-thyroxine substitution beneficial? publication-title: Eur J Endocrinol – volume: 98 start-page: 2256 year: 2013 end-page: 2266 ident: bb0120 article-title: Is subclinical hypothyroidism a cardiovascular risk factor in the elderly? publication-title: J Clin Endocrinol Metab – volume: 100 start-page: 4524 year: 2015 end-page: 4532 ident: bb0360 article-title: Subclinical thyroid dysfunction and frailty among older men publication-title: J Clin Endocrinol Metab – volume: 26 start-page: 432 year: 2011 end-page: 439 ident: bb0065 article-title: Serum TSH level in healthy Koreans and the association of TSH with serum lipid concentration and metabolic syndrome publication-title: Korean J Intern Med – volume: 40 start-page: 95 year: 2011 end-page: 101 ident: bb0395 article-title: Insulin sensitivity, plasma adiponectin and sICAM-1 concentrations in patients with subclinical hypothyroidism: response to levothyroxine therapy publication-title: Endocrine – volume: 54 start-page: 569 year: 2003 end-page: 576 ident: bb0455 article-title: Subclinical hypothyroidism and lipid abnormalities in older women attending a vascular disease prevention clinic: effect of thyroid replacement therapy publication-title: Angiology – volume: 86 start-page: 4860 year: 2001 end-page: 4866 ident: bb0475 article-title: TSH-controlled L-thyroxine therapy reduces cholesterol levels and clinical symptoms in subclinical hypothyroidism: a double blind, placebo-controlled trial (Basel Thyroid Study) publication-title: J Clin Endocrinol Metab – volume: 260 start-page: 53 year: 2006 end-page: 61 ident: bb0425 article-title: Serum lipid levels in relation to serum thyroid-stimulating hormone and the effect of thyroxine treatment on serum lipid levels in subjects with subclinical hypothyroidism: the Tromso Study publication-title: J Intern Med – volume: 63 start-page: 1663 year: 2015 end-page: 1673 ident: bb0125 article-title: Diagnosis and management of subclinical hypothyroidism in elderly adults: a review of the literature publication-title: J Am Geriatr Soc – volume: 3 year: 2007 ident: bb0235 article-title: Thyroid hormone replacement for subclinical hypothyroidism publication-title: Cochrane Database Syst Rev – volume: 14 start-page: 570 year: 2008 end-page: 575 ident: bb0415 article-title: Increased atherogenic low-density lipoprotein cholesterol in untreated subclinical hypothyroidism publication-title: Endocr Pract – volume: 71 start-page: 298 year: 2009 end-page: 303 ident: bb0215 article-title: Effects of 18 publication-title: Clin Endocrinol (Oxf) – volume: 295 start-page: 1033 year: 2006 end-page: 1041 ident: bb0265 article-title: Thyroid status, cardiovascular risk, and mortality in older adults publication-title: JAMA – volume: 17 start-page: 453 year: 2007 end-page: 460 ident: bb0225 article-title: Lipoprotein alterations, hepatic lipase activity, and insulin sensitivity in subclinical hypothyroidism: response to L-T(4) treatment publication-title: Thyroid – volume: 53 start-page: 1512 year: 2004 end-page: 1515 ident: bb0445 article-title: Emerging cardiovascular risk factors in subclinical hypothyroidism: lack of change after restoration of euthyroidism publication-title: Metabolism – volume: 6 start-page: 183 year: 1996 end-page: 188 ident: bb0490 article-title: Effect of L-thyroxine administration on antithyroid antibody levels, lipid profile, and thyroid volume in patients with Hashimoto's thyroiditis publication-title: Thyroid – volume: 98 start-page: 2308 year: 2013 end-page: 2317 ident: bb0105 article-title: Subclinical hypothyroidism and risk for incident myocardial infarction among postmenopausal women publication-title: J Clin Endocrinol Metab – volume: 82 start-page: 592 year: 2015 end-page: 597 ident: bb0135 article-title: Serum free thyroxine levels are positively associated with arterial stiffness in the SardiNIA study publication-title: Clin Endocrinol (Oxf) – volume: 100 start-page: 123 year: 1999 end-page: 128 ident: bb0200 article-title: Insulin resistance syndrome predicts coronary heart disease events in elderly nondiabetic men publication-title: Circulation – volume: 203 start-page: 1273 year: 1930 end-page: 1278 ident: bb0295 article-title: Blood cholesterol values in hyperthyroidism and hypothyroidism - their significance publication-title: N Engl J Med – volume: 100 start-page: 1088 year: 2015 end-page: 1096 ident: bb0355 article-title: Thyroid function in the euthyroid range and adverse outcomes in older adults publication-title: J Clin Endocrinol Metab – volume: 25 start-page: 1104 year: 2015 end-page: 1110 ident: bb0165 article-title: No evidence of association between subclinical thyroid disorders and common carotid intima medial thickness or atherosclerotic plaque publication-title: Nutr Metab Cardiovasc Dis – volume: 18 start-page: 21 year: 2008 end-page: 25 ident: bb0155 article-title: Lack of significant association between intima-media thickness in the carotid artery and serum TSH level publication-title: Tromso Study Thyroid – volume: 10 start-page: 251 year: 2000 end-page: 259 ident: bb0035 article-title: The value of ultrasonography in predicting autoimmune thyroid disease publication-title: Thyroid – volume: 92 start-page: 608 year: 2007 end-page: 611 ident: bb0420 article-title: Effect of levo-thyroxine replacement on non-high-density lipoprotein cholesterol in hypothyroid patients publication-title: J Clin Endocrinol Metab – volume: 93 start-page: 2998 year: 2008 end-page: 3007 ident: bb0075 article-title: The influence of age on the relationship between subclinical hypothyroidism and ischemic heart disease: a metaanalysis publication-title: J Clin Endocrinol Metab – volume: 27 start-page: 897 year: 2004 end-page: 903 ident: bb0435 article-title: The effect of L-thyroxine replacement therapy on lipid based cardiovascular risk in subclinical hypothyroidism publication-title: J Endocrinol Invest – volume: 25 start-page: 457 year: 2016 end-page: 463 ident: bb0365 article-title: Evaluation of selected atherosclerosis risk factors in women with subclinical hypothyroidism treated with L-thyroxine publication-title: Adv Clin Exp Med – volume: 1830 start-page: 3900 year: 2013 end-page: 3907 ident: bb0310 article-title: Thyroid hormone receptors: the challenge of elucidating isotype-specific functions and cell-specific response publication-title: Biochim Biophys Acta – volume: 220 start-page: 996 year: 1972 end-page: 1008 ident: bb0305 publication-title: The coronary drug project. Findings leading to further modifications of its protocol with respect to dextrothyroxine. The coronary drug project research group – volume: 66 start-page: 364 year: 2012 end-page: 368 ident: bb0380 article-title: Effects of treatment with publication-title: Med Arch – volume: 11 start-page: 17 year: 2012 ident: bb0245 article-title: Role of extrathyroidal TSHR expression in adipocyte differentiation and its association with obesity publication-title: Lipids Health Dis – volume: 87 start-page: 1533 year: 2002 end-page: 1538 ident: bb0140 article-title: Lipoprotein profile in subclinical hypothyroidism: response to levothyroxine replacement, a randomized placebo-controlled study publication-title: J Clin Endocrinol Metab – volume: 44 start-page: 1559 year: 1995 end-page: 1563 ident: bb0495 article-title: Effect of L-thyroxine therapy on lipoprotein fractions in overt and subclinical hypothyroidism, with special reference to lipoprotein(a) publication-title: Metabolism – volume: 22 start-page: 1096 year: 2012 end-page: 1103 ident: bb0275 article-title: Age and gender substantially influence the relationship between thyroid status and the lipoprotein profile: results from a large cross-sectional study publication-title: Thyroid – volume: 147 start-page: 4292 year: 2006 end-page: 4302 ident: bb0340 article-title: Mouse sterol response element binding protein-1c gene expression is negatively regulated by thyroid hormone publication-title: Endocrinology – volume: 82 start-page: 592 issue: 4 year: 2015 ident: 10.1016/j.ejim.2016.12.015_bb0135 article-title: Serum free thyroxine levels are positively associated with arterial stiffness in the SardiNIA study publication-title: Clin Endocrinol (Oxf) doi: 10.1111/cen.12532 – volume: 166 start-page: 379 issue: 2 year: 2003 ident: 10.1016/j.ejim.2016.12.015_bb0055 article-title: Elevated C-reactive protein and homocysteine values: cardiovascular risk factors in hypothyroidism? A cross-sectional and a double-blind, placebo-controlled trial publication-title: Atherosclerosis doi: 10.1016/S0021-9150(02)00372-6 – volume: 100 start-page: 123 issue: 2 year: 1999 ident: 10.1016/j.ejim.2016.12.015_bb0200 article-title: Insulin resistance syndrome predicts coronary heart disease events in elderly nondiabetic men publication-title: Circulation doi: 10.1161/01.CIR.100.2.123 – volume: 63 start-page: 1663 issue: 8 year: 2015 ident: 10.1016/j.ejim.2016.12.015_bb0125 article-title: Diagnosis and management of subclinical hypothyroidism in elderly adults: a review of the literature publication-title: J Am Geriatr Soc doi: 10.1111/jgs.13532 – volume: 260 start-page: 53 issue: 1 year: 2006 ident: 10.1016/j.ejim.2016.12.015_bb0425 article-title: Serum lipid levels in relation to serum thyroid-stimulating hormone and the effect of thyroxine treatment on serum lipid levels in subjects with subclinical hypothyroidism: the Tromso Study publication-title: J Intern Med doi: 10.1111/j.1365-2796.2006.01652.x – volume: 92 start-page: 608 issue: 2 year: 2007 ident: 10.1016/j.ejim.2016.12.015_bb0420 article-title: Effect of levo-thyroxine replacement on non-high-density lipoprotein cholesterol in hypothyroid patients publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2006-1605 – volume: 11 start-page: 744 issue: 12 year: 1996 ident: 10.1016/j.ejim.2016.12.015_bb0510 article-title: Does treatment with L-thyroxine influence health status in middle-aged and older adults with subclinical hypothyroidism? publication-title: J Gen Intern Med doi: 10.1007/BF02598988 – volume: 11 start-page: 17 year: 2012 ident: 10.1016/j.ejim.2016.12.015_bb0245 article-title: Role of extrathyroidal TSHR expression in adipocyte differentiation and its association with obesity publication-title: Lipids Health Dis doi: 10.1186/1476-511X-11-17 – volume: 10 start-page: 251 issue: 3 year: 2000 ident: 10.1016/j.ejim.2016.12.015_bb0035 article-title: The value of ultrasonography in predicting autoimmune thyroid disease publication-title: Thyroid doi: 10.1089/thy.2000.10.251 – volume: 1830 start-page: 3900 issue: 7 year: 2013 ident: 10.1016/j.ejim.2016.12.015_bb0310 article-title: Thyroid hormone receptors: the challenge of elucidating isotype-specific functions and cell-specific response publication-title: Biochim Biophys Acta doi: 10.1016/j.bbagen.2012.06.003 – volume: 88 start-page: 3731 issue: 8 year: 2003 ident: 10.1016/j.ejim.2016.12.015_bb0460 article-title: Impaired endothelium-dependent vasodilatation in subclinical hypothyroidism: beneficial effect of levothyroxine therapy publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2003-030039 – volume: 152 start-page: 355 issue: 3 year: 2005 ident: 10.1016/j.ejim.2016.12.015_bb0440 article-title: Effects of levothyroxine treatment on biochemical and hemostasis parameters in patients with hypothyroidism publication-title: Eur J Endocrinol doi: 10.1530/eje.1.01857 – volume: 278 start-page: 34114 issue: 36 year: 2003 ident: 10.1016/j.ejim.2016.12.015_bb0180 article-title: Thyroid hormone regulation and cholesterol metabolism are connected through sterol regulatory element-binding protein-2 (SREBP-2) publication-title: J Biol Chem doi: 10.1074/jbc.M305417200 – volume: 6 start-page: 183 issue: 3 year: 1996 ident: 10.1016/j.ejim.2016.12.015_bb0490 article-title: Effect of L-thyroxine administration on antithyroid antibody levels, lipid profile, and thyroid volume in patients with Hashimoto's thyroiditis publication-title: Thyroid – volume: 86 start-page: 4860 issue: 10 year: 2001 ident: 10.1016/j.ejim.2016.12.015_bb0475 article-title: TSH-controlled L-thyroxine therapy reduces cholesterol levels and clinical symptoms in subclinical hypothyroidism: a double blind, placebo-controlled trial (Basel Thyroid Study) publication-title: J Clin Endocrinol Metab doi: 10.1210/jcem.86.10.7973 – volume: 25 start-page: 485 issue: 5 year: 2015 ident: 10.1016/j.ejim.2016.12.015_bb0115 article-title: Subclinical hypothyroidism might worsen the effects of aging on serum lipid profiles: a population-based case-control study publication-title: Thyroid doi: 10.1089/thy.2014.0219 – volume: 10 start-page: 803 issue: 9 year: 2000 ident: 10.1016/j.ejim.2016.12.015_bb0220 article-title: Changes in lipoprotein(a) levels in overt and subclinical hypothyroidism before and during treatment publication-title: Thyroid doi: 10.1089/thy.2000.10.803 – volume: 204 start-page: e77 issue: 2 year: 2009 ident: 10.1016/j.ejim.2016.12.015_bb0145 article-title: Thyroid function is associated with carotid intima-media thickness in euthyroid subjects publication-title: Atherosclerosis doi: 10.1016/j.atherosclerosis.2008.09.022 – volume: 43 start-page: 731 issue: 6 year: 1996 ident: 10.1016/j.ejim.2016.12.015_bb0485 article-title: Lipoprotein(a) concentration in subclinical hypothyroidism before and after levo-thyroxine therapy publication-title: Endocr J doi: 10.1507/endocrj.43.731 – volume: 148 start-page: 832 issue: 11 year: 2008 ident: 10.1016/j.ejim.2016.12.015_bb0080 article-title: Meta-analysis: subclinical thyroid dysfunction and the risk for coronary heart disease and mortality publication-title: Ann Intern Med doi: 10.7326/0003-4819-148-11-200806030-00225 – volume: 59 start-page: 547 issue: 4 year: 2010 ident: 10.1016/j.ejim.2016.12.015_bb0250 article-title: Thyroid-stimulating hormone stimulates lipolysis in adipocytes in culture and raises serum free fatty acid levels in vivo publication-title: Metabolism doi: 10.1016/j.metabol.2009.08.018 – volume: 97 start-page: 2724 issue: 8 year: 2012 ident: 10.1016/j.ejim.2016.12.015_bb0280 article-title: Thyroid-stimulating hormone levels within the reference range are associated with serum lipid profiles independent of thyroid hormones publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2012-1133 – volume: 112 start-page: 348 issue: 5 year: 2002 ident: 10.1016/j.ejim.2016.12.015_bb0470 article-title: A 6-month randomized trial of thyroxine treatment in women with mild subclinical hypothyroidism publication-title: Am J Med doi: 10.1016/S0002-9343(02)01022-7 – volume: 98 start-page: 3562 issue: 9 year: 2013 ident: 10.1016/j.ejim.2016.12.015_bb0050 article-title: Clinical review: a review of the clinical consequences of variation in thyroid function within the reference range publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2013-1315 – volume: 57 start-page: 253 issue: 3 year: 2010 ident: 10.1016/j.ejim.2016.12.015_bb0405 article-title: Lipid profiles in the untreated patients with Hashimoto thyroiditis and the effects of thyroxine treatment on subclinical hypothyroidism with Hashimoto thyroiditis publication-title: Endocr J doi: 10.1507/endocrj.K09E-315 – volume: 14 start-page: 570 issue: 5 year: 2008 ident: 10.1016/j.ejim.2016.12.015_bb0415 article-title: Increased atherogenic low-density lipoprotein cholesterol in untreated subclinical hypothyroidism publication-title: Endocr Pract doi: 10.4158/EP.14.5.570 – volume: 22 start-page: 1096 issue: 11 year: 2012 ident: 10.1016/j.ejim.2016.12.015_bb0275 article-title: Age and gender substantially influence the relationship between thyroid status and the lipoprotein profile: results from a large cross-sectional study publication-title: Thyroid doi: 10.1089/thy.2012.0013 – volume: 203 start-page: 1273 year: 1930 ident: 10.1016/j.ejim.2016.12.015_bb0295 article-title: Blood cholesterol values in hyperthyroidism and hypothyroidism - their significance publication-title: N Engl J Med doi: 10.1056/NEJM193012252032601 – volume: 87 start-page: 1533 issue: 4 year: 2002 ident: 10.1016/j.ejim.2016.12.015_bb0140 article-title: Lipoprotein profile in subclinical hypothyroidism: response to levothyroxine replacement, a randomized placebo-controlled study publication-title: J Clin Endocrinol Metab doi: 10.1210/jcem.87.4.8378 – volume: 44 start-page: 1559 issue: 12 year: 1995 ident: 10.1016/j.ejim.2016.12.015_bb0495 article-title: Effect of L-thyroxine therapy on lipoprotein fractions in overt and subclinical hypothyroidism, with special reference to lipoprotein(a) publication-title: Metabolism doi: 10.1016/0026-0495(95)90075-6 – volume: 12 start-page: 5 issue: 1 year: 2006 ident: 10.1016/j.ejim.2016.12.015_bb0430 article-title: Levothyroxine replacement therapy in patients with subclinical hypothyroidism and coronary artery disease publication-title: Endocr Pract doi: 10.4158/EP.12.1.5 – volume: 63 start-page: 670 issue: 6 year: 2005 ident: 10.1016/j.ejim.2016.12.015_bb0090 article-title: Thyroid dysfunction and serum lipids: a community-based study publication-title: Clin Endocrinol (Oxf) doi: 10.1111/j.1365-2265.2005.02399.x – volume: 324 start-page: 641 issue: 6098 year: 1986 ident: 10.1016/j.ejim.2016.12.015_bb0315 article-title: The c-erb-A gene encodes a thyroid hormone receptor publication-title: Nature doi: 10.1038/324641a0 – volume: 54 start-page: 569 issue: 5 year: 2003 ident: 10.1016/j.ejim.2016.12.015_bb0455 article-title: Subclinical hypothyroidism and lipid abnormalities in older women attending a vascular disease prevention clinic: effect of thyroid replacement therapy publication-title: Angiology doi: 10.1177/000331970305400506 – volume: 2 start-page: 215 issue: 4 year: 2013 ident: 10.1016/j.ejim.2016.12.015_bb0025 article-title: 2013 ETA guideline: management of Subclinical Hypothyroidism publication-title: Eur Thyroid J doi: 10.1159/000356507 – volume: 67 start-page: 668 issue: 5 year: 2007 ident: 10.1016/j.ejim.2016.12.015_bb0150 article-title: Carotid artery intima media thickness is inversely related to serum free thyroxine in euthyroid subjects publication-title: Clin Endocrinol (Oxf) doi: 10.1111/j.1365-2265.2007.02943.x – volume: 71 start-page: 191 issue: 2 year: 2007 ident: 10.1016/j.ejim.2016.12.015_bb0160 article-title: Characterization of subclinical thyroid dysfunction from cardiovascular and metabolic viewpoints: the Suita study publication-title: Circ J doi: 10.1253/circj.71.191 – volume: 9 start-page: 44 issue: 1 year: 2012 ident: 10.1016/j.ejim.2016.12.015_bb0270 article-title: Thyroid stimulating hormone, independent of thyroid hormone, can elevate the serum total cholesterol level in patients with coronary heart disease: a cross-sectional design publication-title: Nutr Metab (Lond) doi: 10.1186/1743-7075-9-44 – volume: 60 start-page: 65 issue: 1 year: 2013 ident: 10.1016/j.ejim.2016.12.015_bb0385 article-title: Effect of l-thyroxine replacement on apolipoprotein B-48 in overt and subclinical hypothyroid patients publication-title: Endocr J doi: 10.1507/endocrj.EJ12-0226 – volume: 79 start-page: 874 issue: 6 year: 2013 ident: 10.1016/j.ejim.2016.12.015_bb0285 article-title: A cross-sectional study of the association between circulating TSH level and lipid profile in a large Spanish population publication-title: Clin Endocrinol (Oxf) doi: 10.1111/cen.12216 – volume: 92 start-page: 30 year: 2016 ident: 10.1016/j.ejim.2016.12.015_bb0290 article-title: Menopause modulates the association between thyrotropin levels and lipid parameters: the SardiNIA study publication-title: Maturitas doi: 10.1016/j.maturitas.2016.07.003 – volume: 11 start-page: 1135 issue: 10 year: 2010 ident: 10.1016/j.ejim.2016.12.015_bb0005 article-title: Thyroid hormone receptor and lipid regulation publication-title: Curr Opin Investig Drugs – volume: 6 start-page: 451 issue: 6 year: 2004 ident: 10.1016/j.ejim.2016.12.015_bb0185 article-title: Hypothyroidism and dyslipidemia: modern concepts and approaches publication-title: Curr Cardiol Rep doi: 10.1007/s11886-004-0054-3 – volume: 66 start-page: 1321 issue: 8 year: 2011 ident: 10.1016/j.ejim.2016.12.015_bb0390 article-title: Effects of thyroxine replacement on endothelial function and carotid artery intima-media thickness in female patients with mild subclinical hypothyroidism publication-title: Clinics (Sao Paulo) – volume: 291 start-page: 228 issue: 2 year: 2004 ident: 10.1016/j.ejim.2016.12.015_bb0015 article-title: Subclinical thyroid disease: scientific review and guidelines for diagnosis and management publication-title: JAMA doi: 10.1001/jama.291.2.228 – volume: 13 start-page: 365 issue: 4 year: 2003 ident: 10.1016/j.ejim.2016.12.015_bb0465 article-title: Lipoprotein (a) levels and apolipoprotein (a) isoform size in patients with subclinical hypothyroidism: effect of treatment with levothyroxine publication-title: Thyroid doi: 10.1089/105072503321669857 – volume: 275 start-page: 81 issue: 1 year: 1998 ident: 10.1016/j.ejim.2016.12.015_bb0480 article-title: Sex steroids, lipids, and lipoprotein cholesterols in women with subclinical and overt hypothyroidism before and after L-thyroxine therapy publication-title: Clin Chim Acta doi: 10.1016/S0009-8981(98)00074-6 – volume: 93 start-page: 2998 issue: 8 year: 2008 ident: 10.1016/j.ejim.2016.12.015_bb0075 article-title: The influence of age on the relationship between subclinical hypothyroidism and ischemic heart disease: a metaanalysis publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2008-0167 – volume: 320 start-page: 915 issue: 14 year: 1989 ident: 10.1016/j.ejim.2016.12.015_bb0190 article-title: Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity publication-title: N Engl J Med – volume: 3 year: 2007 ident: 10.1016/j.ejim.2016.12.015_bb0235 article-title: Thyroid hormone replacement for subclinical hypothyroidism publication-title: Cochrane Database Syst Rev doi: 10.1002/14651858.CD003419.pub2 – volume: 147 start-page: 4292 issue: 9 year: 2006 ident: 10.1016/j.ejim.2016.12.015_bb0340 article-title: Mouse sterol response element binding protein-1c gene expression is negatively regulated by thyroid hormone publication-title: Endocrinology doi: 10.1210/en.2006-0116 – volume: 119 start-page: 541 issue: 7 year: 2006 ident: 10.1016/j.ejim.2016.12.015_bb0260 article-title: Subclinical hypothyroidism and the risk of coronary heart disease: a meta-analysis publication-title: Am J Med doi: 10.1016/j.amjmed.2005.09.028 – volume: 27 start-page: 897 issue: 10 year: 2004 ident: 10.1016/j.ejim.2016.12.015_bb0435 article-title: The effect of L-thyroxine replacement therapy on lipid based cardiovascular risk in subclinical hypothyroidism publication-title: J Endocrinol Invest doi: 10.1007/BF03347530 – volume: 100 start-page: 1088 issue: 3 year: 2015 ident: 10.1016/j.ejim.2016.12.015_bb0355 article-title: Thyroid function in the euthyroid range and adverse outcomes in older adults publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2014-3586 – volume: 3 start-page: 76 issue: 2 year: 2014 ident: 10.1016/j.ejim.2016.12.015_bb0030 article-title: 2014 European thyroid association guidelines for the management of subclinical hypothyroidism in pregnancy and in children publication-title: Eur Thyroid J doi: 10.1159/000362597 – volume: 98 start-page: 2308 issue: 6 year: 2013 ident: 10.1016/j.ejim.2016.12.015_bb0105 article-title: Subclinical hypothyroidism and risk for incident myocardial infarction among postmenopausal women publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2012-4065 – volume: 86 start-page: 732 issue: 2 year: 2001 ident: 10.1016/j.ejim.2016.12.015_bb0060 article-title: Components of the fibrinolytic system are differently altered in moderate and severe hypothyroidism publication-title: J Clin Endocrinol Metab doi: 10.1210/jcem.86.2.7221 – volume: 100 start-page: 4524 issue: 12 year: 2015 ident: 10.1016/j.ejim.2016.12.015_bb0360 article-title: Subclinical thyroid dysfunction and frailty among older men publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2015-3191 – volume: 203 start-page: 269 issue: 1 year: 2009 ident: 10.1016/j.ejim.2016.12.015_bb0170 article-title: Hypothyroidism is not associated with increased carotid atherosclerosis when cardiovascular risk factors are accounted for in hyperlipidemic patients publication-title: Atherosclerosis doi: 10.1016/j.atherosclerosis.2008.06.011 – volume: 128 start-page: 202 issue: 3 year: 1993 ident: 10.1016/j.ejim.2016.12.015_bb0500 article-title: Subclinical hypothyroidism and hyperlipoproteinaemia: indiscriminate L-thyroxine treatment not justified publication-title: Acta Endocrinol doi: 10.1530/acta.0.1280202 – volume: 98 start-page: 2256 issue: 6 year: 2013 ident: 10.1016/j.ejim.2016.12.015_bb0120 article-title: Is subclinical hypothyroidism a cardiovascular risk factor in the elderly? publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2012-3818 – volume: 71 start-page: 298 issue: 2 year: 2009 ident: 10.1016/j.ejim.2016.12.015_bb0215 article-title: Effects of 18months of L-T4 replacement in women with subclinical hypothyroidism publication-title: Clin Endocrinol (Oxf) doi: 10.1111/j.1365-2265.2008.03509.x – volume: 220 start-page: 996 issue: 7 year: 1972 ident: 10.1016/j.ejim.2016.12.015_bb0305 publication-title: JAMA doi: 10.1001/jama.1972.03200070084015 – volume: 117 start-page: 696 issue: 9 year: 2004 ident: 10.1016/j.ejim.2016.12.015_bb0230 article-title: Disturbed metabolism of remnant lipoproteins in patients with subclinical hypothyroidism publication-title: Am J Med doi: 10.1016/j.amjmed.2004.04.027 – volume: 40 start-page: 95 issue: 1 year: 2011 ident: 10.1016/j.ejim.2016.12.015_bb0395 article-title: Insulin sensitivity, plasma adiponectin and sICAM-1 concentrations in patients with subclinical hypothyroidism: response to levothyroxine therapy publication-title: Endocrine doi: 10.1007/s12020-011-9446-5 – volume: 52 start-page: 1401 issue: 4 year: 2010 ident: 10.1016/j.ejim.2016.12.015_bb0255 publication-title: Hepatology doi: 10.1002/hep.23800 – volume: 21 start-page: 166 issue: 3 year: 2010 ident: 10.1016/j.ejim.2016.12.015_bb0010 article-title: Thyroid hormone crosstalk with nuclear receptor signaling in metabolic regulation publication-title: Trends Endocrinol Metab doi: 10.1016/j.tem.2009.11.004 – volume: 18 start-page: 21 issue: 1 year: 2008 ident: 10.1016/j.ejim.2016.12.015_bb0155 article-title: Lack of significant association between intima-media thickness in the carotid artery and serum TSH level publication-title: Tromso Study Thyroid doi: 10.1089/thy.2007.0165 – volume: 97 start-page: 326 issue: 2 year: 2012 ident: 10.1016/j.ejim.2016.12.015_bb0175 article-title: Update in lipid alterations in subclinical hypothyroidism publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2011-2532 – volume: 88 start-page: 2438 issue: 6 year: 2003 ident: 10.1016/j.ejim.2016.12.015_bb0095 article-title: Hypothyroidism and atherosclerosis publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2003-030398 – volume: 21 start-page: 347 issue: 4 year: 2011 ident: 10.1016/j.ejim.2016.12.015_bb0400 article-title: Lipid metabolism in subclinical hypothyroidism: plasma kinetics of triglyceride-rich lipoproteins and lipid transfers to high-density lipoprotein before and after levothyroxine treatment publication-title: Thyroid doi: 10.1089/thy.2010.0313 – volume: 17 start-page: 453 issue: 5 year: 2007 ident: 10.1016/j.ejim.2016.12.015_bb0225 article-title: Lipoprotein alterations, hepatic lipase activity, and insulin sensitivity in subclinical hypothyroidism: response to L-T(4) treatment publication-title: Thyroid doi: 10.1089/thy.2006.0302 – volume: 16 start-page: 1767 issue: 8 year: 2002 ident: 10.1016/j.ejim.2016.12.015_bb0335 article-title: Requirement for thyroid hormone receptor beta in T3 regulation of cholesterol metabolism in mice publication-title: Mol Endocrinol doi: 10.1210/me.2002-0009 – volume: 29 start-page: 479 issue: 5 year: 1996 ident: 10.1016/j.ejim.2016.12.015_bb0195 article-title: Low-density lipoprotein composition and oxidability in atherosclerotic cardiovascular disease publication-title: Clin Biochem doi: 10.1016/0009-9120(96)00069-0 – volume: 18 start-page: 825 issue: 8 year: 2008 ident: 10.1016/j.ejim.2016.12.015_bb0410 article-title: The effect of levothyroxine on arterial stiffness and lipid profile in patients with subclinical hypothyroidism publication-title: Thyroid doi: 10.1089/thy.2007.0359 – volume: 17 start-page: 243 issue: 3 year: 2007 ident: 10.1016/j.ejim.2016.12.015_bb0240 article-title: An examination of the relationship between normal range thyrotropin and cardiovascular risk parameters: a study in healthy women publication-title: Thyroid doi: 10.1089/thy.2006.0208 – volume: 29 start-page: 76 issue: 1 year: 2008 ident: 10.1016/j.ejim.2016.12.015_bb0070 article-title: The clinical significance of subclinical thyroid dysfunction publication-title: Endocr Rev doi: 10.1210/er.2006-0043 – volume: 53 start-page: 1512 issue: 11 year: 2004 ident: 10.1016/j.ejim.2016.12.015_bb0445 article-title: Emerging cardiovascular risk factors in subclinical hypothyroidism: lack of change after restoration of euthyroidism publication-title: Metabolism doi: 10.1016/j.metabol.2004.05.016 – volume: 2 start-page: 455 issue: 6 year: 2014 ident: 10.1016/j.ejim.2016.12.015_bb0350 article-title: Eprotirome in patients with familial hypercholesterolaemia (the AKKA trial): a randomised, double-blind, placebo-controlled phase 3 study publication-title: Lancet Diabetes Endocrinol doi: 10.1016/S2213-8587(14)70006-3 – volume: 87 start-page: 4662 issue: 10 year: 2002 ident: 10.1016/j.ejim.2016.12.015_bb0130 article-title: Increased central arterial stiffness in hypothyroidism publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2002-020493 – volume: 25 start-page: 457 issue: 3 year: 2016 ident: 10.1016/j.ejim.2016.12.015_bb0365 article-title: Evaluation of selected atherosclerosis risk factors in women with subclinical hypothyroidism treated with L-thyroxine publication-title: Adv Clin Exp Med doi: 10.17219/acem/38555 – volume: 66 start-page: 364 issue: 6 year: 2012 ident: 10.1016/j.ejim.2016.12.015_bb0380 article-title: Effects of treatment with l-thyroxin on glucose regulation in patients with subclinical hypothyroidism publication-title: Med Arch doi: 10.5455/medarh.2012.66.364-368 – volume: 87 start-page: 3221 issue: 7 year: 2002 ident: 10.1016/j.ejim.2016.12.015_bb0040 article-title: Prospective study of the spontaneous course of subclinical hypothyroidism: prognostic value of thyrotropin, thyroid reserve, and thyroid antibodies publication-title: J Clin Endocrinol Metab doi: 10.1210/jcem.87.7.8678 – volume: 90 start-page: 4019 issue: 7 year: 2005 ident: 10.1016/j.ejim.2016.12.015_bb0045 article-title: Small differences in thyroid function may be important for body mass index and the occurrence of obesity in the population publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2004-2225 – volume: 295 start-page: 1033 issue: 9 year: 2006 ident: 10.1016/j.ejim.2016.12.015_bb0265 article-title: Thyroid status, cardiovascular risk, and mortality in older adults publication-title: JAMA doi: 10.1001/jama.295.9.1033 – volume: 26 start-page: 432 issue: 4 year: 2011 ident: 10.1016/j.ejim.2016.12.015_bb0065 article-title: Serum TSH level in healthy Koreans and the association of TSH with serum lipid concentration and metabolic syndrome publication-title: Korean J Intern Med doi: 10.3904/kjim.2011.26.4.432 – volume: 362 start-page: 906 issue: 10 year: 2010 ident: 10.1016/j.ejim.2016.12.015_bb0325 article-title: Use of the thyroid hormone analogue eprotirome in statin-treated dyslipidemia publication-title: N Engl J Med doi: 10.1056/NEJMoa0905633 – volume: 25 start-page: S2 year: 1998 ident: 10.1016/j.ejim.2016.12.015_bb0320 article-title: Molecular and structural biology of thyroid hormone receptors publication-title: Clin Exp Pharmacol Physiol Suppl doi: 10.1111/j.1440-1681.1998.tb02293.x – volume: 304 start-page: 1365 issue: 12 year: 2010 ident: 10.1016/j.ejim.2016.12.015_bb0110 article-title: Subclinical hypothyroidism and the risk of coronary heart disease and mortality publication-title: JAMA doi: 10.1001/jama.2010.1361 – volume: 125 start-page: 459 issue: 1 year: 1989 ident: 10.1016/j.ejim.2016.12.015_bb0330 publication-title: Endocrinology doi: 10.1210/endo-125-1-459 – volume: 134 start-page: 1127 issue: 4 year: 2008 ident: 10.1016/j.ejim.2016.12.015_bb0345 article-title: Dramatically increased intestinal absorption of cholesterol following hypophysectomy is normalized by thyroid hormone publication-title: Gastroenterology doi: 10.1053/j.gastro.2008.01.032 – volume: 26 start-page: 1019 issue: 8 year: 2016 ident: 10.1016/j.ejim.2016.12.015_bb0370 article-title: A worthy finding: decrease in total cholesterol and low-density lipoprotein cholesterol in treated mild subclinical hypothyroidism publication-title: Thyroid doi: 10.1089/thy.2016.0010 – volume: 33 start-page: 413 issue: 7 year: 1994 ident: 10.1016/j.ejim.2016.12.015_bb0515 article-title: Disturbed lipid metabolism in patients with subclinical hypothyroidism: effect of L-thyroxine therapy publication-title: Intern Med doi: 10.2169/internalmedicine.33.413 – volume: 98 start-page: 533 issue: 2 year: 2013 ident: 10.1016/j.ejim.2016.12.015_bb0100 article-title: Persistent subclinical hypothyroidism and cardiovascular risk in the elderly: the cardiovascular health study publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2012-2180 – volume: 25 start-page: 1104 issue: 12 year: 2015 ident: 10.1016/j.ejim.2016.12.015_bb0165 article-title: No evidence of association between subclinical thyroid disorders and common carotid intima medial thickness or atherosclerotic plaque publication-title: Nutr Metab Cardiovasc Dis doi: 10.1016/j.numecd.2015.09.001 – volume: 89 start-page: 2099 issue: 5 year: 2004 ident: 10.1016/j.ejim.2016.12.015_bb0450 article-title: Effect of levothyroxine replacement on lipid profile and intima-media thickness in subclinical hypothyroidism: a double-blind, placebo-controlled study publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2003-031669 – volume: 61 start-page: 232 issue: 2 year: 2004 ident: 10.1016/j.ejim.2016.12.015_bb0085 article-title: Subclinical hypothyroidism is associated with a low-grade inflammation, increased triglyceride levels and predicts cardiovascular disease in males below 50years publication-title: Clin Endocrinol (Oxf) doi: 10.1111/j.1365-2265.2004.02088.x – volume: 68 start-page: 857 issue: 7 year: 2014 ident: 10.1016/j.ejim.2016.12.015_bb0375 article-title: The effect of L-thyroxine substitution on lipid profile, glucose homeostasis, inflammation and coagulation in patients with subclinical hypothyroidism publication-title: Int J Clin Pract doi: 10.1111/ijcp.12394 – volume: 151 start-page: 224 issue: 4 year: 2008 ident: 10.1016/j.ejim.2016.12.015_bb0205 article-title: Lipid profile in different degrees of hypothyroidism and effects of levothyroxine replacement in mild thyroid failure publication-title: Transl Res doi: 10.1016/j.trsl.2007.12.006 – volume: 272 start-page: 120 issue: 6960 year: 1957 ident: 10.1016/j.ejim.2016.12.015_bb0300 article-title: Long-term effect of dried thyroid on serum-lipoprotein and serum-cholesterol levels publication-title: Lancet – volume: 145 start-page: 705 issue: 6 year: 2001 ident: 10.1016/j.ejim.2016.12.015_bb0210 article-title: Lipid profile in subclinical hypothyroidism: is L-thyroxine substitution beneficial? publication-title: Eur J Endocrinol doi: 10.1530/eje.0.1450705 – volume: 171 start-page: 143 issue: 1 year: 2014 ident: 10.1016/j.ejim.2016.12.015_bb0020 article-title: Prevalence of unknown thyroid disorders in a Sardinian cohort publication-title: Eur J Endocrinol doi: 10.1530/EJE-14-0182 – volume: 150 start-page: 2097 issue: 10 year: 1990 ident: 10.1016/j.ejim.2016.12.015_bb0505 article-title: Lipoprotein and apolipoprotein levels in subclinical hypothyroidism. Effect of levothyroxine therapy publication-title: Arch Intern Med doi: 10.1001/archinte.1990.00390210077017 |
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| Snippet | Subclinical hypothyroidism is defined by elevated serum thyrotropin in presence of normal free thyroid hormones. Lipid metabolism is influenced by thyroid... Abstract Subclinical hypothyroidism is defined by elevated serum thyrotropin in presence of normal free thyroid hormones. Lipid metabolism is influenced by... |
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| SubjectTerms | Blood Pressure Cardiovascular disease Cardiovascular Diseases - complications Cardiovascular risk Carotid Intima-Media Thickness Humans Hypothyroidism - complications Internal Medicine Lipid Metabolism Metabolic Syndrome - complications Risk Factors Subclinical hypothyroidism Thyroid Gland - physiopathology Thyrotropin - blood Thyroxine - therapeutic use |
| Title | Subclinical hypothyroidism, lipid metabolism and cardiovascular disease |
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