Subclinical hypothyroidism, lipid metabolism and cardiovascular disease

Subclinical hypothyroidism is defined by elevated serum thyrotropin in presence of normal free thyroid hormones. Lipid metabolism is influenced by thyroid hormone and many reports showed that lipids status worsen along with TSH level. Subclinical hypothyroidism has been also linked to other cardiova...

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Published in:European journal of internal medicine Vol. 38; pp. 17 - 24
Main Authors: Delitala, Alessandro P, Fanciulli, Giuseppe, Maioli, Margherita, Delitala, Giuseppe
Format: Journal Article
Language:English
Published: Netherlands Elsevier B.V 01.03.2017
Subjects:
Blood Pressure
Cardiovascular disease
Cardiovascular Diseases - complications
Cardiovascular risk
Carotid Intima-Media Thickness
Humans
Hypothyroidism - complications
Internal Medicine
Lipid Metabolism
Metabolic Syndrome - complications
Risk Factors
Subclinical hypothyroidism
Thyroid Gland - physiopathology
Thyrotropin - blood
Thyroxine - therapeutic use
FT3
LDL-C
FT4
SREBP-2
TSH
HMG-CoA
Cardiovascular disease
LT4
Lp(a)
TC
CVD
HDL-C
IMT
TG
LDL-R
Subclinical hypothyroidism
Cardiovascular risk
SCH
Lipid metabolism
CHD
TR
BMI
hydroxymethylglutaryl coenzyme A reductase
sterol regulatory element-binding protein-2
intima media thickness
low density lipoprotein receptor
total cholesterol
lipoprotein (a)
thyrotropin
thyroid hormone receptor
free thyroxine
subclinical hypothyroidism
cardiovascular disease
body mass index
free triiodothyronine
triglycerides
high density lipoprotein cholesterol
levothyroxine
coronary heart disease
low density lipoprotein cholesterol
ISSN:0953-6205, 1879-0828, 1879-0828
Online Access:Get full text
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Summary:Subclinical hypothyroidism is defined by elevated serum thyrotropin in presence of normal free thyroid hormones. Lipid metabolism is influenced by thyroid hormone and many reports showed that lipids status worsen along with TSH level. Subclinical hypothyroidism has been also linked to other cardiovascular risk factors such as alteration in blood pressure and increased atherosclerosis. Further evidences suggested that mild dysfunction of thyroid gland is associated with metabolic syndrome and heart failure. Thyrotropin level seems the best predictor of cardiovascular disease, in particular when its levels are above 10mU/L. However, despite these observations, there is no clear evidence that levothyroxine therapy in subjects with milder form of subclinical hypothyroidism could improve lipid status and the other cardiovascular risk factors. In this review, we address the effect of thyroid hormone and cardiovascular risk, with a focus on lipid metabolism. •Thyroid hormones regulates lipid metabolism.•Subclinical hypothyroidism could worsen lipid status.•The beneficial effect of levo-thyroxine substitute therapy on lipids require further studies.
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ISSN:0953-6205
1879-0828
1879-0828
DOI:10.1016/j.ejim.2016.12.015