Mitochondrial biogenesis is required for the anchorage-independent survival and propagation of stem-like cancer cells

Here, we show that new mitochondrial biogenesis is required for the anchorage independent survival and propagation of cancer stem-like cells (CSCs). More specifically, we used the drug XCT790 as an investigational tool, as it functions as a specific inhibitor of the ERRα-PGC1 signaling pathway, whic...

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Bibliographic Details
Published in:	Oncotarget Vol. 6; no. 17; pp. 14777 - 14795
Main Authors:	De Luca, Arianna, Fiorillo, Marco, Peiris-Pagès, Maria, Ozsvari, Bela, Smith, Duncan L, Sanchez-Alvarez, Rosa, Martinez-Outschoorn, Ubaldo E, Cappello, Anna Rita, Pezzi, Vincenzo, Lisanti, Michael P, Sotgia, Federica
Format:	Journal Article
Language:	English
Published:	United States 20.06.2015
Subjects:	Acetylcarnitine - pharmacology Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Cell Adhesion - drug effects Cell Adhesion - physiology Cell Proliferation - drug effects Cell Proliferation - physiology Cell Survival - drug effects Cell Survival - physiology Chromatography, Liquid Doxycycline - pharmacology ERRalpha Estrogen-Related Receptor Forkhead Box Protein M1 Forkhead Transcription Factors - genetics Forkhead Transcription Factors - metabolism Glycolysis - drug effects Humans MCF-7 Cells Mitochondria - drug effects Mitochondria - metabolism Neoplastic Stem Cells - drug effects Neoplastic Stem Cells - metabolism Nitriles - pharmacology Oligomycins - pharmacology Organelle Biogenesis Oxidative Phosphorylation - drug effects Proteomics - methods Receptors, Estrogen - genetics Receptors, Estrogen - metabolism Signal Transduction - drug effects Spheroids, Cellular - drug effects Spheroids, Cellular - metabolism Tandem Mass Spectrometry Thiazoles - pharmacology Wnt Signaling Pathway - drug effects drug repurposing ERR-α XCT790 doxycycline PGC1-α/β
ISSN:	1949-2553
Online Access:	Get more information
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