Association of SOD2 (rs4880) and GPX1 (rs1050450) Gene Polymorphisms with Risk of Balkan Endemic Nephropathy and its Related Tumors

Background and Objectives: Experimental data show that superoxide dismutase 2 (SOD2) is involved in ochratoxin (OTA)-induced nephrotoxicity, whereas clinical data indicate the role of SOD2 rs4880 or glutathione peroxidase 1 (GPX1) rs1050450 polymorphisms in end-stage renal disease and urothelial car...

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Vydáno v:Medicina (Kaunas, Lithuania) Ročník 55; číslo 8; s. 435
Hlavní autoři: Dragicevic, Biljana, Suvakov, Sonja, Jerotic, Djurdja, Reljic, Zorica, Djukanovic, Ljubica, Zelen, Ivanka, Pljesa-Ercegovac, Marija, Savic-Radojevic, Ana, Simic, Tatjana, Dragicevic, Dejan, Matic, Marija
Médium: Journal Article
Jazyk:angličtina
Vydáno: Switzerland MDPI 03.08.2019
MDPI AG
Témata:
Aged
Aged, 80 and over
Balkan endemic nephropathy
Balkan Nephropathy - epidemiology
Balkan Nephropathy - genetics
Balkan Nephropathy - physiopathology
Biomarkers - analysis
Biomarkers - blood
Bosnia and Herzegovina - epidemiology
Female
gene polymorphism
glutathione peroxidase
Glutathione Peroxidase - blood
Glutathione Peroxidase - genetics
Humans
Male
Polymorphism, Genetic - genetics
Serbia - epidemiology
superoxide dismutase
Superoxide Dismutase - blood
Superoxide Dismutase - genetics
Serbia
Bosnia and Herzegovina
gene polymorphism
Balkan endemic nephropathy
superoxide dismutase
glutathione peroxidase
ISSN:1648-9144, 1010-660X, 1648-9144, 1010-660X
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Shrnutí:Background and Objectives: Experimental data show that superoxide dismutase 2 (SOD2) is involved in ochratoxin (OTA)-induced nephrotoxicity, whereas clinical data indicate the role of SOD2 rs4880 or glutathione peroxidase 1 (GPX1) rs1050450 polymorphisms in end-stage renal disease and urothelial carcinoma risk, known to be the major complications of Balkan endemic nephropathy (BEN). Therefore, we hypothesized that SOD2 and GPX1 gene polymorphisms would influence the risk of BEN and its associated tumors. Materials and Methods: The study was conducted in 207 BEN patients and 86 controls from endemic areas. Results: Individuals with both copies of variant SOD2 allele, known for lower mitochondrial antioxidant protection, are at a significantly higher BEN risk (OR = 2.6, p = 0.021). No association was observed between GPX1 gene polymorphism and BEN risk. Combining SOD2 and GPX1 genotypes did not alter the risk of BEN development. Regarding the risk of urothelial tumors in BEN patients, none of the polymorphisms studied was significantly associated with the risk of these tumors. Conclusions: Polymorphism in SOD2 rs4880 gene affects the risk of BEN development. Hence, SOD2 genotyping could, together with a panel of other enzymes, be used as a biomarker of susceptibility in BEN areas.
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These authors contributed equally to this work.
ISSN:1648-9144
1010-660X
1648-9144
1010-660X
DOI:10.3390/medicina55080435