Evaluation and Treatment of Autoimmune Neurologic Disorders in the Pediatric Intensive Care Unit

Autoimmunity is being increasingly recognized as a cause of neurologic presentations both inside and outside the intensive care unit (ICU) setting. Pediatric autoimmune neurologic diseases likely to be seen in the ICU include autoimmune encephalitidies such as N-Methyl-D-aspartate (NMDA) receptor en...

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Vydáno v:Seminars in pediatric neurology Ročník 21; číslo 4; s. 284 - 290
Hlavní autoři: Benson, Leslie A., Olson, Heather, Gorman, Mark P.
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States Elsevier Inc 01.12.2014
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ISSN:1071-9091, 1558-0776, 1558-0776
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Shrnutí:Autoimmunity is being increasingly recognized as a cause of neurologic presentations both inside and outside the intensive care unit (ICU) setting. Pediatric autoimmune neurologic diseases likely to be seen in the ICU include autoimmune encephalitidies such as N-Methyl-D-aspartate (NMDA) receptor encephalitis, central nervous system vasculitis, demyelinating disorders, and neurologic involvement of systemic autoimmune disorders. In addition, there are conditions of suspected autoimmune etiology such as febrile infection–related epilepsy syndrome (FIRES) and rapid-onset obesity, hypoventilation, hypothalamic dysfunction, and autonomic dysregulation (ROHHAD) syndrome that are rare, but when they do present, it is often to the ICU. Refractory seizures, altered mental status, and disordered breathing are the most common indications for intensive care for these patients.
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ISSN:1071-9091
1558-0776
1558-0776
DOI:10.1016/j.spen.2014.12.008