Ketamine and Active Ketamine Metabolites Regulate STAT3 and the Type I Interferon Pathway in Human Microglia: Molecular Mechanisms Linked to the Antidepressant Effects of Ketamine

Inflammation is an important biological process which contributes to risk for depression, in part as a result of the production of proinflammatory cytokines and of alterations in glutamatergic neurotransmission. Ketamine has anti-inflammatory properties which might contribute to its antidepressant e...

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Bibliographic Details

Published in:	Frontiers in pharmacology Vol. 10; p. 1302
Main Authors:	Ho, Ming-Fen, Zhang, Cheng, Zhang, Lingxin, Li, Hu, Weinshilboum, Richard M.
Format:	Journal Article
Language:	English
Published:	Switzerland Frontiers Media S.A 05.11.2019
Subjects:	antidepressant gene expression ketamine microglia Pharmacology RNA-seq RNA-seq ketamine microglia gene expression antidepressant
ISSN:	1663-9812, 1663-9812
Online Access:	Get full text
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