Liposphere mediated topical delivery of thymoquinone in the treatment of psoriasis

Thymoquinone (TMQ) is reported with good anti-psoriatic activity; however, the hydrophobicity, poor aqueous solubility, light and pH sensitive nature of TMQ hinder its delivery to target site. To address these delivery challenges of TMQ, lipospheres were explored. The topical use of lipospheres offe...

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Bibliographic Details
Published in:Nanomedicine Vol. 13; no. 7; pp. 2251 - 2262
Main Authors: Jain, Anjali, Pooladanda, Venkatesh, Bulbake, Upendra, Doppalapudi, Sindhu, Rafeeqi, Towseef Amin, Godugu, Chandraiah, Khan, Wahid
Format: Journal Article
Language:English
Published: United States Elsevier Inc 01.10.2017
Subjects:
Administration, Topical
Animals
Anti-Inflammatory Agents - administration & dosage
Anti-Inflammatory Agents - pharmacokinetics
Anti-Inflammatory Agents - therapeutic use
Benzoquinones - administration & dosage
Benzoquinones - pharmacokinetics
Benzoquinones - therapeutic use
Imiquimod induced psoriatic plaque model
Inflammation
Interleukin-17 - analysis
Interleukin-2 - analysis
Interleukin-6 - analysis
Internal Medicine
Liposomes
Lipospheres
Male
Mice
Mice, Inbred BALB C
Psoriasis
Psoriasis - drug therapy
RAW 264.7 Cells
Skin - drug effects
Skin - pathology
Skin Absorption
Thymoquinone
Tumor Necrosis Factor-alpha - analysis
Inflammation
Psoriasis
Lipospheres
Thymoquinone
Imiquimod induced psoriatic plaque model
Imiquimod induced psoriatic mice model
ISSN:1549-9634, 1549-9642, 1549-9642
Online Access:Get full text
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Summary:Thymoquinone (TMQ) is reported with good anti-psoriatic activity; however, the hydrophobicity, poor aqueous solubility, light and pH sensitive nature of TMQ hinder its delivery to target site. To address these delivery challenges of TMQ, lipospheres were explored. The topical use of lipospheres offers an effective mean of penetration along with stability and scalability. TMQ lipospheres of particle size below 70 nm were prepared and evaluated. These lipospheres resulted in deeper skin penetration, slow release and skin compatibility. Anti-inflammatory and anti-psoriatic potential of lipospheres was determined using in vitro cell lines and imiquimod induced psoriatic plaque model. Cell lines studies indicated reduction in the level of nitric oxide and IL-2, IL-6, IL-1β, TNF-α, whereas in vivo results indicated improvement in the phenotypic, histopathological features and reduced level of IL-17 and TNF-α in psoriatic skin. These results suggest the potential of TMQ lipospheres in the management of psoriasis. Present work explores the potential of TMQ lipospheres in the treatment of psoriasis. TMQ loaded lipospheres were prepared and characterized for suitability in TMQ topical delivery. In vitro and in vivo studies were performed to determine the anti-inflammatory and anti-psoriatic activity of these lipospheres. Results suggest the potential of TMQ lipospheres in the management of psoriasis. [Display omitted]
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ISSN:1549-9634
1549-9642
1549-9642
DOI:10.1016/j.nano.2017.06.009