Perinatal complications and long-term neurodevelopmental outcome of infants with intrauterine growth restriction
The objective of the study was to evaluate perinatal and long-term complications of fetuses with intrauterine growth restriction (IUGR) compared with constitutionally small for gestational age (SGA) ones. The outcome of infants with IUGR and SGA born at the Medical University Graz (Austria) between...
Saved in:
| Published in: | American journal of obstetrics and gynecology Vol. 208; no. 2; pp. 130.e1 - 130.e6 |
|---|---|
| Main Authors: | , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
United States
Mosby, Inc
01.02.2013
|
| Subjects: | |
| ISSN: | 0002-9378, 1097-6868, 1097-6868 |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract | The objective of the study was to evaluate perinatal and long-term complications of fetuses with intrauterine growth restriction (IUGR) compared with constitutionally small for gestational age (SGA) ones.
The outcome of infants with IUGR and SGA born at the Medical University Graz (Austria) between 2003 and 2009 was retrospectively analyzed. Group assignment was based on birthweight, Doppler ultrasound, and placental morphology. The primary outcome was neurodevelopmental delay at 2 years corrected age. The secondary outcomes were perinatal complications.
We included 219 IUGR and 299 SGA infants for perinatal and 146 and 215 for long-term analysis. Fetuses with IUGR were delivered earlier (35 vs 38 weeks) and had higher rates of mortality (8% vs 1%; odds ratio [OR], 8.3) as well as perinatal complications (24.4% vs 1.0%; OR, 31.6). The long-term outcome was affected by increased risk for neurodevelopmental impairment (24.7% vs 5.6%; OR, 5.5) and growth delay (21.2% vs 7.4%; OR, 3.4).
IUGR infants are subject to an increased risk for adverse short- and long-term outcome compared with SGA children. |
|---|---|
| AbstractList | The objective of the study was to evaluate perinatal and long-term complications of fetuses with intrauterine growth restriction (IUGR) compared with constitutionally small for gestational age (SGA) ones.
The outcome of infants with IUGR and SGA born at the Medical University Graz (Austria) between 2003 and 2009 was retrospectively analyzed. Group assignment was based on birthweight, Doppler ultrasound, and placental morphology. The primary outcome was neurodevelopmental delay at 2 years corrected age. The secondary outcomes were perinatal complications.
We included 219 IUGR and 299 SGA infants for perinatal and 146 and 215 for long-term analysis. Fetuses with IUGR were delivered earlier (35 vs 38 weeks) and had higher rates of mortality (8% vs 1%; odds ratio [OR], 8.3) as well as perinatal complications (24.4% vs 1.0%; OR, 31.6). The long-term outcome was affected by increased risk for neurodevelopmental impairment (24.7% vs 5.6%; OR, 5.5) and growth delay (21.2% vs 7.4%; OR, 3.4).
IUGR infants are subject to an increased risk for adverse short- and long-term outcome compared with SGA children. Objective The objective of the study was to evaluate perinatal and long-term complications of fetuses with intrauterine growth restriction (IUGR) compared with constitutionally small for gestational age (SGA) ones. Study Design The outcome of infants with IUGR and SGA born at the Medical University Graz (Austria) between 2003 and 2009 was retrospectively analyzed. Group assignment was based on birthweight, Doppler ultrasound, and placental morphology. The primary outcome was neurodevelopmental delay at 2 years corrected age. The secondary outcomes were perinatal complications. Results We included 219 IUGR and 299 SGA infants for perinatal and 146 and 215 for long-term analysis. Fetuses with IUGR were delivered earlier (35 vs 38 weeks) and had higher rates of mortality (8% vs 1%; odds ratio [OR], 8.3) as well as perinatal complications (24.4% vs 1.0%; OR, 31.6). The long-term outcome was affected by increased risk for neurodevelopmental impairment (24.7% vs 5.6%; OR, 5.5) and growth delay (21.2% vs 7.4%; OR, 3.4). Conclusion IUGR infants are subject to an increased risk for adverse short- and long-term outcome compared with SGA children. The objective of the study was to evaluate perinatal and long-term complications of fetuses with intrauterine growth restriction (IUGR) compared with constitutionally small for gestational age (SGA) ones.OBJECTIVEThe objective of the study was to evaluate perinatal and long-term complications of fetuses with intrauterine growth restriction (IUGR) compared with constitutionally small for gestational age (SGA) ones.The outcome of infants with IUGR and SGA born at the Medical University Graz (Austria) between 2003 and 2009 was retrospectively analyzed. Group assignment was based on birthweight, Doppler ultrasound, and placental morphology. The primary outcome was neurodevelopmental delay at 2 years corrected age. The secondary outcomes were perinatal complications.STUDY DESIGNThe outcome of infants with IUGR and SGA born at the Medical University Graz (Austria) between 2003 and 2009 was retrospectively analyzed. Group assignment was based on birthweight, Doppler ultrasound, and placental morphology. The primary outcome was neurodevelopmental delay at 2 years corrected age. The secondary outcomes were perinatal complications.We included 219 IUGR and 299 SGA infants for perinatal and 146 and 215 for long-term analysis. Fetuses with IUGR were delivered earlier (35 vs 38 weeks) and had higher rates of mortality (8% vs 1%; odds ratio [OR], 8.3) as well as perinatal complications (24.4% vs 1.0%; OR, 31.6). The long-term outcome was affected by increased risk for neurodevelopmental impairment (24.7% vs 5.6%; OR, 5.5) and growth delay (21.2% vs 7.4%; OR, 3.4).RESULTSWe included 219 IUGR and 299 SGA infants for perinatal and 146 and 215 for long-term analysis. Fetuses with IUGR were delivered earlier (35 vs 38 weeks) and had higher rates of mortality (8% vs 1%; odds ratio [OR], 8.3) as well as perinatal complications (24.4% vs 1.0%; OR, 31.6). The long-term outcome was affected by increased risk for neurodevelopmental impairment (24.7% vs 5.6%; OR, 5.5) and growth delay (21.2% vs 7.4%; OR, 3.4).IUGR infants are subject to an increased risk for adverse short- and long-term outcome compared with SGA children.CONCLUSIONIUGR infants are subject to an increased risk for adverse short- and long-term outcome compared with SGA children. |
| Author | von Beckerath, Anne-Karen Rotky-Fast, Christa Karpf, Eva Klaritsch, Philipp Lang, Uwe Kollmann, Martina |
| Author_xml | – sequence: 1 givenname: Anne-Karen surname: von Beckerath fullname: von Beckerath, Anne-Karen organization: Department of Obstetrics and Gynecology, Medical University of Graz, Graz, Austria – sequence: 2 givenname: Martina surname: Kollmann fullname: Kollmann, Martina organization: Department of Obstetrics and Gynecology, Medical University of Graz, Graz, Austria – sequence: 3 givenname: Christa surname: Rotky-Fast fullname: Rotky-Fast, Christa organization: Department of Pediatrics and Adolescent Medicine, Medical University of Graz, Graz, Austria – sequence: 4 givenname: Eva surname: Karpf fullname: Karpf, Eva organization: Institute of Pathology, Medical University of Graz, Graz, Austria – sequence: 5 givenname: Uwe surname: Lang fullname: Lang, Uwe organization: Department of Obstetrics and Gynecology, Medical University of Graz, Graz, Austria – sequence: 6 givenname: Philipp surname: Klaritsch fullname: Klaritsch, Philipp email: philipp.klaritsch@medunigraz.at organization: Department of Obstetrics and Gynecology, Medical University of Graz, Graz, Austria |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/23159694$$D View this record in MEDLINE/PubMed |
| BookMark | eNqFkk-L1TAUxYOMOG9Gv4AL6dJNa27alzYiggz-gwEFdR3S9PaZmiY1SWeYb2_qm9kMOK7CDed3Qs65Z-TEeYeEPAdaAQX-aqrU5A8Vo8AqgIpC84jsgIq25B3vTsiOUspKUbfdKTmLcdpGJtgTcspq2Asumh1ZvmIwTiVlC-3nxRqtkvEuFsoNhfXuUCYMc-FwDX7AK7R-mdFtcr-mTGDhx8K4UbkUi2uTfuYhBbWmzRaLQ_DX-S5gTMHozfkpeTwqG_HZ7XlOfnx4__3iU3n55ePni3eXpW44S2XTDwrZvkcAPfK2rQVHJdTIlaprTQekuqZq0EoDNA3bQ9v3ArAdWxgptqo-Jy-Pvkvwv9f8vpxN1GitcujXKIF1meootFn64la69jMOcglmVuFG3qWUBd1RoIOPMeAotUl_c8pfNVYClVshcpJbIXIrRALIXEhG2T30zv1B6M0RwhzQlcEgozboNA4moE5y8OZh_O09XFvjcrP2F95gnPwaXI5egoxMUvlt24ttS4BRRrnossHrfxv87_U_Ff3QJA |
| CitedBy_id | crossref_primary_10_1016_j_anpede_2015_09_033 crossref_primary_10_1016_j_mce_2016_01_025 crossref_primary_10_1016_j_actatropica_2014_03_005 crossref_primary_10_3390_biomedicines13030542 crossref_primary_10_1038_s41380_024_02772_6 crossref_primary_10_1371_journal_pone_0088496 crossref_primary_10_1159_000382013 crossref_primary_10_1007_s13669_013_0041_z crossref_primary_10_1093_ntr_ntv072 crossref_primary_10_1007_s00234_021_02786_9 crossref_primary_10_1016_j_ajog_2019_06_026 crossref_primary_10_1111_jpc_13808 crossref_primary_10_1186_s10020_020_00253_4 crossref_primary_10_3109_14767058_2015_1081893 crossref_primary_10_1016_j_vaccine_2017_01_042 crossref_primary_10_3390_ijms25031386 crossref_primary_10_1186_s13643_021_01711_8 crossref_primary_10_1038_s41598_021_82144_0 crossref_primary_10_1186_s12887_022_03542_5 crossref_primary_10_1001_jamanetworkopen_2025_7217 crossref_primary_10_1542_neo_17_2_e108 crossref_primary_10_1097_PRS_0000000000005108 crossref_primary_10_3390_nu14030451 crossref_primary_10_7759_cureus_31611 crossref_primary_10_1016_j_endinu_2021_04_005 crossref_primary_10_1159_000507583 crossref_primary_10_1016_j_gofs_2022_11_003 crossref_primary_10_1016_j_jsbmb_2018_01_015 crossref_primary_10_1016_j_mce_2016_03_017 crossref_primary_10_1016_j_scitotenv_2024_171386 crossref_primary_10_3389_fnins_2023_1092357 crossref_primary_10_7554_eLife_82631 crossref_primary_10_1016_j_ajog_2016_11_1008 crossref_primary_10_3233_NPM_200621 crossref_primary_10_1002_ajim_23516 crossref_primary_10_1016_j_ogc_2021_02_004 crossref_primary_10_1093_molehr_gaab006 crossref_primary_10_1016_j_jogc_2016_09_038 crossref_primary_10_3390_ijms26157388 crossref_primary_10_1016_j_clnesp_2025_06_010 crossref_primary_10_1038_s41581_022_00668_8 crossref_primary_10_1016_j_ajog_2018_09_043 crossref_primary_10_3390_antiox10030405 crossref_primary_10_1016_j_ajog_2017_04_020 crossref_primary_10_1542_neo_19_8_e456 crossref_primary_10_1097_JPN_0000000000000603 crossref_primary_10_1159_000516845 crossref_primary_10_1136_bmjopen_2023_074417 crossref_primary_10_3389_fendo_2018_00570 crossref_primary_10_1016_j_earlhumdev_2020_104951 crossref_primary_10_1136_bmjopen_2018_028243 crossref_primary_10_1016_j_siny_2016_08_007 crossref_primary_10_1016_j_placenta_2020_03_010 crossref_primary_10_1016_j_ajog_2017_11_566 crossref_primary_10_1002_uog_70095 crossref_primary_10_1136_archdischild_2016_310791 crossref_primary_10_1159_000479675 crossref_primary_10_3109_14767058_2014_934219 crossref_primary_10_1111_ajo_12264 crossref_primary_10_1016_j_placenta_2019_10_002 crossref_primary_10_1515_jpm_2019_0016 crossref_primary_10_1016_S1701_2163_15_30865_3 crossref_primary_10_1016_j_jgyn_2013_09_020 crossref_primary_10_1136_bmjmed_2023_000784 crossref_primary_10_1016_j_jogc_2016_08_001 crossref_primary_10_1111_aogs_13730 crossref_primary_10_1016_j_ajog_2014_05_008 crossref_primary_10_3109_14767058_2014_947952 crossref_primary_10_1016_j_placenta_2022_06_007 crossref_primary_10_1016_j_jpeds_2016_09_072 crossref_primary_10_1017_S2040174418000831 crossref_primary_10_1016_j_endien_2022_03_006 crossref_primary_10_3389_fcvm_2022_931943 crossref_primary_10_1016_j_anpedi_2015_09_012 crossref_primary_10_1111_jpc_12910 crossref_primary_10_1002_uog_27609 crossref_primary_10_1007_s10995_020_03070_7 crossref_primary_10_1113_JP271402 crossref_primary_10_1080_16070658_2025_2538402 crossref_primary_10_1016_j_placenta_2014_06_001 crossref_primary_10_1186_s13072_019_0254_0 crossref_primary_10_1007_s00404_013_2973_y crossref_primary_10_1186_s12958_018_0421_3 crossref_primary_10_1002_ijgo_14721 crossref_primary_10_1016_j_pcl_2018_12_009 crossref_primary_10_1016_j_gofs_2021_04_004 crossref_primary_10_1038_s41598_022_22895_6 crossref_primary_10_5114_pjr_2023_126224 crossref_primary_10_1002_uog_29238 crossref_primary_10_1016_j_ejogrb_2020_12_023 crossref_primary_10_1007_s00394_014_0809_6 crossref_primary_10_1186_s40748_016_0031_z crossref_primary_10_1016_S1701_2163_15_30866_5 crossref_primary_10_1515_cclm_2023_0294 crossref_primary_10_1007_s11892_020_01331_x crossref_primary_10_1097_MD_0000000000024681 crossref_primary_10_1007_s10565_024_09855_8 crossref_primary_10_1016_j_ajog_2015_10_004 crossref_primary_10_1002_uog_22185 crossref_primary_10_1016_j_jgyn_2013_09_014 crossref_primary_10_1016_S2352_4642_18_30245_1 crossref_primary_10_1515_jpm_2023_0156 crossref_primary_10_3389_fped_2021_741793 crossref_primary_10_1016_j_molmed_2014_04_005 crossref_primary_10_1016_j_jgyn_2013_09_019 crossref_primary_10_1038_pr_2017_37 crossref_primary_10_1155_2017_9382083 crossref_primary_10_1186_s12887_023_04361_y crossref_primary_10_3109_14767058_2015_1048431 crossref_primary_10_3390_jcm9051448 crossref_primary_10_1001_jamanetworkopen_2023_31815 crossref_primary_10_3389_fped_2014_00118 crossref_primary_10_1159_000464272 crossref_primary_10_1080_01443615_2021_1993801 crossref_primary_10_3109_14767058_2016_1157576 |
| Cites_doi | 10.1016/0029-7844(94)00430-L 10.1542/peds.71.3.376 10.1002/uog.10055 10.1053/j.semperi.2008.04.010 10.1002/uog.1836 10.1111/j.1440-1754.1995.tb00847.x 10.1016/S0002-9378(00)70494-7 10.1002/uog.9008 10.1016/j.ajog.2010.10.915 10.1016/S0002-9378(99)70283-8 10.1016/0028-2243(91)90104-S 10.1136/adc.51.11.820 10.1111/j.1651-2227.1985.tb10922.x 10.1111/j.1469-8749.1997.tb07414.x 10.7863/jum.2005.24.9.1223 10.1136/jcp.2008.055236 10.1542/peds.113.3.515 10.1055/s-0029-1241833 10.1002/uog.20 10.1056/NEJMoa041367 10.1016/j.reprotox.2005.04.007 10.1056/NEJM199904223401603 10.1046/j.0960-7692.2001.00590.x 10.1002/uog.7738 10.1136/jcp.2008.055244 10.1002/uog.6286 10.1016/S0002-9378(00)70505-9 10.1002/uog.11112 |
| ContentType | Journal Article |
| Copyright | 2013 Mosby, Inc. Mosby, Inc. Copyright © 2013 Mosby, Inc. All rights reserved. |
| Copyright_xml | – notice: 2013 Mosby, Inc. – notice: Mosby, Inc. – notice: Copyright © 2013 Mosby, Inc. All rights reserved. |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 |
| DOI | 10.1016/j.ajog.2012.11.014 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1097-6868 |
| EndPage | 130.e6 |
| ExternalDocumentID | 23159694 10_1016_j_ajog_2012_11_014 S0002937812020698 1_s2_0_S0002937812020698 |
| Genre | Journal Article Comparative Study |
| GeographicLocations | Austria |
| GeographicLocations_xml | – name: Austria |
| GroupedDBID | --- --K --M -ET .1- .55 .FO .GJ .XZ .~1 0R~ 1B1 1CY 1P~ 1~. 1~5 23M 2KS 354 3O- 4.4 457 4CK 4G. 53G 5GY 5RE 5VS 6J9 7-5 85S 8F7 8P~ AAEDT AAEDW AAIKC AAIKJ AAKOC AALRI AAMNW AAOAW AAQFI AAQQT AAQXK AATTM AAWTL AAXKI AAXUO AAYJJ AAYWO ABBQC ABCQX ABDPE ABFNM ABFRF ABJNI ABMAC ABMZM ABOCM ABPMR ABWVN ABXDB ACDAQ ACGFO ACGFS ACIEU ACLOT ACRLP ACRPL ACVFH ADBBV ADCNI ADEZE ADMUD ADNMO ADVLN AEBSH AEFWE AEIPS AEKER AENEX AEUPX AEVXI AFCHL AFFNX AFJKZ AFPUW AFRHN AFTJW AFXIZ AGHFR AGNAY AGQPQ AGUBO AGYEJ AHDLI AI. AIEXJ AIGII AIIUN AIKHN AITUG AJRQY AJUYK AKBMS AKRWK AKYEP ALMA_UNASSIGNED_HOLDINGS AMRAJ ANKPU ANZVX APXCP ASPBG AVWKF AXJTR AZFZN BKOJK BLXMC BNPGV C45 C5W CAG COF CS3 EBS EFJIC EFKBS EFLBG EJD EO8 EX3 F5P FDB FEDTE FGOYB FIRID FNPLU FYGXN G-Q GBLVA HVGLF HZ~ IH2 IHE J1W K-O KOM LPU M41 MO0 N4W N9A NEJ NQ- O-L O9- OAUVE OBH OCB OGEVE OHH OHT OMK OQ. OVD P-8 P-9 P2P PC. PH~ Q38 R2- ROL RPZ RXW SDF SEL SES SEW SJN SPCBC SSH SSZ T5K TAE TEORI TWZ UDS UGJ UHB UHS UHU UKR UNMZH UV1 VH1 VVN WH7 WOQ WOW X6Y X7M XFW YFH YOC YYQ YZZ Z5R ZGI ZXP ZY1 ~G- ~H1 ~HD AACTN AFCTW AFKWA AJOXV AMFUW NCXOZ RIG AAIAV ABLVK ABYKQ ADOJD AFDAS AHPSJ AJBFU G8K LCYCR ZA5 AAYXX CITATION XRW AGCQF AGRNS CGR CUY CVF ECM EIF NPM 7X8 |
| ID | FETCH-LOGICAL-c462t-4bdae25be11cf677396ea9af6aa33c0de0c30adcac11442517bb91e7f71f0e7a3 |
| ISICitedReferencesCount | 139 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000314018700015&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 0002-9378 1097-6868 |
| IngestDate | Sun Sep 28 11:09:09 EDT 2025 Mon Jul 21 06:05:34 EDT 2025 Sat Nov 29 07:33:34 EST 2025 Tue Nov 18 22:35:05 EST 2025 Fri Feb 23 02:34:13 EST 2024 Sun Feb 23 10:18:55 EST 2025 Tue Oct 14 19:34:50 EDT 2025 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 2 |
| Keywords | intrauterine growth restriction neurodevelopmental impairment small for gestational age Doppler ultrasound |
| Language | English |
| License | Copyright © 2013 Mosby, Inc. All rights reserved. |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c462t-4bdae25be11cf677396ea9af6aa33c0de0c30adcac11442517bb91e7f71f0e7a3 |
| Notes | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 |
| PMID | 23159694 |
| PQID | 1282518017 |
| PQPubID | 23479 |
| ParticipantIDs | proquest_miscellaneous_1282518017 pubmed_primary_23159694 crossref_citationtrail_10_1016_j_ajog_2012_11_014 crossref_primary_10_1016_j_ajog_2012_11_014 elsevier_sciencedirect_doi_10_1016_j_ajog_2012_11_014 elsevier_clinicalkeyesjournals_1_s2_0_S0002937812020698 elsevier_clinicalkey_doi_10_1016_j_ajog_2012_11_014 |
| PublicationCentury | 2000 |
| PublicationDate | 2013-02-01 |
| PublicationDateYYYYMMDD | 2013-02-01 |
| PublicationDate_xml | – month: 02 year: 2013 text: 2013-02-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States |
| PublicationTitle | American journal of obstetrics and gynecology |
| PublicationTitleAlternate | Am J Obstet Gynecol |
| PublicationYear | 2013 |
| Publisher | Mosby, Inc |
| Publisher_xml | – name: Mosby, Inc |
| References | Roberts, Post (bib6) 2008; 61 Bhide (bib30) 2011; 38 Bayley (bib27) 1993 Rantakallio (bib11) 1985; 74 Lees, Baumgartner (bib33) 2005; 25 (bib26) 1976 Palisano, Rosenbaum, Walter, Russell, Wood, Galuppi (bib28) 1997; 39 Douglas, Gear (bib16) 1976; 51 Odibo, Riddick, Pare, Stamilio, Macones (bib21) 2005; 24 Voigt, Rochow, Hesse, Olbertz, Schneider, Jorch (bib18) 2010; 214 Baschat (bib17) 2011; 37 Bahado-Singh, Kovanci, Jeffres (bib19) 1999; 180 Baschat, Weiner (bib8) 2000; 182 Baschat, Gembruch (bib20) 2003; 21 McCowan, Harding, Roberts, Barker, Ford, Stewart (bib7) 2000; 182 Neilson, Alfirevic (bib9) 2000 Faye-Petersen (bib23) 2008; 61 Grantham-McGregor (bib10) 1998; 52 Lagerstrom, Bremme, Eneroth, Janson (bib13) 1991; 40 Morley, Fewtrell, Abbott, Stephenson, MacFadyen, Lucas (bib29) 2004; 113 Baschat, Viscardi, Hussey-Gardner, Hashmi, Harman (bib24) 2009; 33 Oros, Figueras, Cruz-Martinez, Meler, Munmany, Gratacos (bib22) 2011; 37 Pryor, Silva, Brooke (bib12) 1995; 31 Miller, Turan, Baschat (bib4) 2008; 32 McIntire, Bloom, Casey, Leveno (bib2) 1999; 340 Arcangeli, Thilaganathan, Hooper, Khan, Bhide (bib3) 2012; 40 Hecher, Bilardo, Stigter (bib32) 2001; 18 Resnik (bib1) 2002; 99 Paz, Gale, Laor, Danon, Stevenson, Seidman (bib14) 1995; 85 Westwood, Kramer, Munz, Lovett, Watters (bib15) 1983; 71 Ergaz, Avgil, Ornoy (bib5) 2005; 20 Marlow, Wolke, Bracewell, Samara (bib25) 2005; 352 Baschat, Odibo (bib31) 2011; 204 Hecher (10.1016/j.ajog.2012.11.014_bib32) 2001; 18 McIntire (10.1016/j.ajog.2012.11.014_bib2) 1999; 340 Baschat (10.1016/j.ajog.2012.11.014_bib31) 2011; 204 Douglas (10.1016/j.ajog.2012.11.014_bib16) 1976; 51 Pryor (10.1016/j.ajog.2012.11.014_bib12) 1995; 31 Resnik (10.1016/j.ajog.2012.11.014_bib1) 2002; 99 Palisano (10.1016/j.ajog.2012.11.014_bib28) 1997; 39 Morley (10.1016/j.ajog.2012.11.014_bib29) 2004; 113 Oros (10.1016/j.ajog.2012.11.014_bib22) 2011; 37 Bayley (10.1016/j.ajog.2012.11.014_bib27) 1993 Rantakallio (10.1016/j.ajog.2012.11.014_bib11) 1985; 74 Marlow (10.1016/j.ajog.2012.11.014_bib25) 2005; 352 Arcangeli (10.1016/j.ajog.2012.11.014_bib3) 2012; 40 Bhide (10.1016/j.ajog.2012.11.014_bib30) 2011; 38 Baschat (10.1016/j.ajog.2012.11.014_bib17) 2011; 37 Voigt (10.1016/j.ajog.2012.11.014_bib18) 2010; 214 Faye-Petersen (10.1016/j.ajog.2012.11.014_bib23) 2008; 61 Grantham-McGregor (10.1016/j.ajog.2012.11.014_bib10) 1998; 52 Baschat (10.1016/j.ajog.2012.11.014_bib24) 2009; 33 Miller (10.1016/j.ajog.2012.11.014_bib4) 2008; 32 Baschat (10.1016/j.ajog.2012.11.014_bib20) 2003; 21 Lagerstrom (10.1016/j.ajog.2012.11.014_bib13) 1991; 40 Neilson (10.1016/j.ajog.2012.11.014_bib9) 2000 (10.1016/j.ajog.2012.11.014_bib26) 1976 Lees (10.1016/j.ajog.2012.11.014_bib33) 2005; 25 Baschat (10.1016/j.ajog.2012.11.014_bib8) 2000; 182 Ergaz (10.1016/j.ajog.2012.11.014_bib5) 2005; 20 Paz (10.1016/j.ajog.2012.11.014_bib14) 1995; 85 McCowan (10.1016/j.ajog.2012.11.014_bib7) 2000; 182 Roberts (10.1016/j.ajog.2012.11.014_bib6) 2008; 61 Westwood (10.1016/j.ajog.2012.11.014_bib15) 1983; 71 Bahado-Singh (10.1016/j.ajog.2012.11.014_bib19) 1999; 180 Odibo (10.1016/j.ajog.2012.11.014_bib21) 2005; 24 |
| References_xml | – volume: 214 start-page: 24 year: 2010 end-page: 29 ident: bib18 article-title: Short communication about percentile values of body measures of newborn babies publication-title: Z Geburtshilfe Neonatol – volume: 21 start-page: 124 year: 2003 end-page: 127 ident: bib20 article-title: The cerebroplacental doppler ratio revisited publication-title: Ultrasound Obstet Gynecol – volume: 52 start-page: S59 year: 1998 end-page: S64 ident: bib10 article-title: Small for gestational age, term babies, in the first six years of life publication-title: Eur J Clin Nutr – volume: 37 start-page: 191 year: 2011 end-page: 195 ident: bib22 article-title: Longitudinal changes in uterine, umbilical and fetal cerebral doppler indices in late-onset small-for-gestational age fetuses publication-title: Ultrasound Obstet Gynecol – volume: 40 start-page: 129 year: 1991 end-page: 136 ident: bib13 article-title: School marks and IQ-test scores for low birth weight children at the age of 13 years publication-title: Eur J Obstet Gynecol Reprod Biol – volume: 61 start-page: 1261 year: 2008 end-page: 1275 ident: bib23 article-title: The placenta in preterm birth publication-title: J Clin Pathol – volume: 51 start-page: 820 year: 1976 end-page: 827 ident: bib16 article-title: Children of low birthweight in the 1946 national cohort. behaviour and educational achievement in adolescence publication-title: Arch Dis Child – volume: 24 start-page: 1223 year: 2005 end-page: 1228 ident: bib21 article-title: Cerebroplacental doppler ratio and adverse perinatal outcomes in intrauterine growth restriction: evaluating the impact of using gestational age-specific reference values publication-title: J Ultrasound Med – year: 2000 ident: bib9 article-title: Doppler ultrasound for fetal assessment in high risk pregnancies publication-title: Cochrane Database Syst Rev – volume: 113 start-page: 515 year: 2004 end-page: 521 ident: bib29 article-title: Neurodevelopment in children born small for gestational age: a randomized trial of nutrient-enriched versus standard formula and comparison with a reference breastfed group publication-title: Pediatrics – volume: 71 start-page: 376 year: 1983 end-page: 382 ident: bib15 article-title: Growth and development of full-term nonasphyxiated small-for-gestational-age newborns: follow-up through adolescence publication-title: Pediatrics – volume: 25 start-page: 105 year: 2005 end-page: 107 ident: bib33 article-title: The TRUFFLE study–a collaborative publicly funded project from concept to reality: how to negotiate an ethical, administrative and funding obstacle course in the European Union publication-title: Ultrasound Obstet Gynecol – volume: 182 start-page: 154 year: 2000 end-page: 158 ident: bib8 article-title: Umbilical artery doppler screening for detection of the small fetus in need of antepartum surveillance publication-title: Am J Obstet Gynecol – volume: 99 start-page: 490 year: 2002 end-page: 496 ident: bib1 article-title: Intrauterine growth restriction publication-title: Obstet Gynecol – volume: 182 start-page: 81 year: 2000 end-page: 86 ident: bib7 article-title: A pilot randomized controlled trial of two regimens of fetal surveillance for small-for-gestational-age fetuses with normal results of umbilical artery Doppler velocimetry publication-title: Am J Obstet Gynecol – volume: 18 start-page: 564 year: 2001 end-page: 570 ident: bib32 article-title: Monitoring of fetuses with intrauterine growth restriction: a longitudinal study publication-title: Ultrasound Obstet Gynecol – volume: 20 start-page: 301 year: 2005 end-page: 322 ident: bib5 article-title: Intrauterine growth restriction-etiology and consequences: what do we know about the human situation and experimental animal models? publication-title: Reprod Toxicol – volume: 74 start-page: 62 year: 1985 end-page: 69 ident: bib11 article-title: A 14-year follow-up of children with normal and abnormal birth weight for their gestational age publication-title: Acta Paediatr Scand – volume: 33 start-page: 44 year: 2009 end-page: 50 ident: bib24 article-title: Infant neurodevelopment following fetal growth restriction: Relationship with antepartum surveillance parameters publication-title: Ultrasound Obstet Gynecol – volume: 352 start-page: 9 year: 2005 end-page: 19 ident: bib25 article-title: Neurologic and developmental disability at six years of age after extremely preterm birth publication-title: N Engl J Med – volume: 204 start-page: 2 year: 2011 end-page: 3 ident: bib31 article-title: Timing of delivery in fetal growth restriction and childhood development: some uncertainties remain publication-title: Am J Obstet Gynecol – volume: 39 start-page: 214 year: 1997 end-page: 223 ident: bib28 article-title: Development and reliability of a system to classify gross motor function in children with cerebral palsy publication-title: Dev Med Child Neurol – volume: 180 start-page: 750 year: 1999 end-page: 756 ident: bib19 article-title: The doppler cerebroplacental ratio and perinatal outcome in intrauterine growth restriction publication-title: Am J Obstet Gynecol – volume: 40 start-page: 267 year: 2012 end-page: 275 ident: bib3 article-title: Neurodevelopmental delay in small babies at term publication-title: Ultrasound Obstet Gynecol – volume: 85 start-page: 452 year: 1995 end-page: 456 ident: bib14 article-title: The cognitive outcome of full-term small for gestational age infants at late adolescence publication-title: Obstet Gynecol – volume: 61 start-page: 1254 year: 2008 end-page: 1260 ident: bib6 article-title: The placenta in pre-eclampsia and intrauterine growth restriction publication-title: J Clin Pathol – volume: 32 start-page: 274 year: 2008 end-page: 280 ident: bib4 article-title: Fetal growth restriction publication-title: Semin Perinatol – year: 1993 ident: bib27 article-title: Bayley scales of infant development – volume: 38 start-page: 243 year: 2011 end-page: 245 ident: bib30 article-title: Fetal growth restriction and developmental delay: current understanding and future possibilities publication-title: Ultrasound Obstet Gynecol – volume: 31 start-page: 403 year: 1995 end-page: 407 ident: bib12 article-title: Growth, development and behaviour in adolescents born small-for-gestational-age publication-title: J Paediatr Child Health – volume: 340 start-page: 1234 year: 1999 end-page: 1238 ident: bib2 article-title: Birth weight in relation to morbidity and mortality among newborn infants publication-title: N Engl J Med – year: 1976 ident: bib26 publication-title: Neurological development in infancy – volume: 37 start-page: 501 year: 2011 end-page: 514 ident: bib17 article-title: Neurodevelopment following fetal growth restriction and its relationship with antepartum parameters of placental dysfunction publication-title: Ultrasound Obstet Gynecol – volume: 99 start-page: 490 year: 2002 ident: 10.1016/j.ajog.2012.11.014_bib1 article-title: Intrauterine growth restriction publication-title: Obstet Gynecol – volume: 85 start-page: 452 year: 1995 ident: 10.1016/j.ajog.2012.11.014_bib14 article-title: The cognitive outcome of full-term small for gestational age infants at late adolescence publication-title: Obstet Gynecol doi: 10.1016/0029-7844(94)00430-L – year: 1976 ident: 10.1016/j.ajog.2012.11.014_bib26 – volume: 71 start-page: 376 year: 1983 ident: 10.1016/j.ajog.2012.11.014_bib15 article-title: Growth and development of full-term nonasphyxiated small-for-gestational-age newborns: follow-up through adolescence publication-title: Pediatrics doi: 10.1542/peds.71.3.376 – volume: 38 start-page: 243 year: 2011 ident: 10.1016/j.ajog.2012.11.014_bib30 article-title: Fetal growth restriction and developmental delay: current understanding and future possibilities publication-title: Ultrasound Obstet Gynecol doi: 10.1002/uog.10055 – volume: 32 start-page: 274 year: 2008 ident: 10.1016/j.ajog.2012.11.014_bib4 article-title: Fetal growth restriction publication-title: Semin Perinatol doi: 10.1053/j.semperi.2008.04.010 – year: 1993 ident: 10.1016/j.ajog.2012.11.014_bib27 – volume: 25 start-page: 105 year: 2005 ident: 10.1016/j.ajog.2012.11.014_bib33 article-title: The TRUFFLE study–a collaborative publicly funded project from concept to reality: how to negotiate an ethical, administrative and funding obstacle course in the European Union publication-title: Ultrasound Obstet Gynecol doi: 10.1002/uog.1836 – volume: 31 start-page: 403 year: 1995 ident: 10.1016/j.ajog.2012.11.014_bib12 article-title: Growth, development and behaviour in adolescents born small-for-gestational-age publication-title: J Paediatr Child Health doi: 10.1111/j.1440-1754.1995.tb00847.x – volume: 182 start-page: 81 issue: 1 Pt 1 year: 2000 ident: 10.1016/j.ajog.2012.11.014_bib7 article-title: A pilot randomized controlled trial of two regimens of fetal surveillance for small-for-gestational-age fetuses with normal results of umbilical artery Doppler velocimetry publication-title: Am J Obstet Gynecol doi: 10.1016/S0002-9378(00)70494-7 – volume: 37 start-page: 501 year: 2011 ident: 10.1016/j.ajog.2012.11.014_bib17 article-title: Neurodevelopment following fetal growth restriction and its relationship with antepartum parameters of placental dysfunction publication-title: Ultrasound Obstet Gynecol doi: 10.1002/uog.9008 – volume: 204 start-page: 2 year: 2011 ident: 10.1016/j.ajog.2012.11.014_bib31 article-title: Timing of delivery in fetal growth restriction and childhood development: some uncertainties remain publication-title: Am J Obstet Gynecol doi: 10.1016/j.ajog.2010.10.915 – volume: 180 start-page: 750 issue: 3 Pt 1 year: 1999 ident: 10.1016/j.ajog.2012.11.014_bib19 article-title: The doppler cerebroplacental ratio and perinatal outcome in intrauterine growth restriction publication-title: Am J Obstet Gynecol doi: 10.1016/S0002-9378(99)70283-8 – volume: 40 start-page: 129 year: 1991 ident: 10.1016/j.ajog.2012.11.014_bib13 article-title: School marks and IQ-test scores for low birth weight children at the age of 13 years publication-title: Eur J Obstet Gynecol Reprod Biol doi: 10.1016/0028-2243(91)90104-S – volume: 51 start-page: 820 year: 1976 ident: 10.1016/j.ajog.2012.11.014_bib16 article-title: Children of low birthweight in the 1946 national cohort. behaviour and educational achievement in adolescence publication-title: Arch Dis Child doi: 10.1136/adc.51.11.820 – volume: 74 start-page: 62 year: 1985 ident: 10.1016/j.ajog.2012.11.014_bib11 article-title: A 14-year follow-up of children with normal and abnormal birth weight for their gestational age publication-title: Acta Paediatr Scand doi: 10.1111/j.1651-2227.1985.tb10922.x – volume: 39 start-page: 214 year: 1997 ident: 10.1016/j.ajog.2012.11.014_bib28 article-title: Development and reliability of a system to classify gross motor function in children with cerebral palsy publication-title: Dev Med Child Neurol doi: 10.1111/j.1469-8749.1997.tb07414.x – volume: 24 start-page: 1223 year: 2005 ident: 10.1016/j.ajog.2012.11.014_bib21 article-title: Cerebroplacental doppler ratio and adverse perinatal outcomes in intrauterine growth restriction: evaluating the impact of using gestational age-specific reference values publication-title: J Ultrasound Med doi: 10.7863/jum.2005.24.9.1223 – volume: 61 start-page: 1254 year: 2008 ident: 10.1016/j.ajog.2012.11.014_bib6 article-title: The placenta in pre-eclampsia and intrauterine growth restriction publication-title: J Clin Pathol doi: 10.1136/jcp.2008.055236 – volume: 52 start-page: S59 issue: Suppl 1 year: 1998 ident: 10.1016/j.ajog.2012.11.014_bib10 article-title: Small for gestational age, term babies, in the first six years of life publication-title: Eur J Clin Nutr – volume: 113 start-page: 515 issue: 3 Pt 1 year: 2004 ident: 10.1016/j.ajog.2012.11.014_bib29 article-title: Neurodevelopment in children born small for gestational age: a randomized trial of nutrient-enriched versus standard formula and comparison with a reference breastfed group publication-title: Pediatrics doi: 10.1542/peds.113.3.515 – volume: 214 start-page: 24 year: 2010 ident: 10.1016/j.ajog.2012.11.014_bib18 article-title: Short communication about percentile values of body measures of newborn babies publication-title: Z Geburtshilfe Neonatol doi: 10.1055/s-0029-1241833 – volume: 21 start-page: 124 year: 2003 ident: 10.1016/j.ajog.2012.11.014_bib20 article-title: The cerebroplacental doppler ratio revisited publication-title: Ultrasound Obstet Gynecol doi: 10.1002/uog.20 – year: 2000 ident: 10.1016/j.ajog.2012.11.014_bib9 article-title: Doppler ultrasound for fetal assessment in high risk pregnancies publication-title: Cochrane Database Syst Rev – volume: 352 start-page: 9 year: 2005 ident: 10.1016/j.ajog.2012.11.014_bib25 article-title: Neurologic and developmental disability at six years of age after extremely preterm birth publication-title: N Engl J Med doi: 10.1056/NEJMoa041367 – volume: 20 start-page: 301 year: 2005 ident: 10.1016/j.ajog.2012.11.014_bib5 article-title: Intrauterine growth restriction-etiology and consequences: what do we know about the human situation and experimental animal models? publication-title: Reprod Toxicol doi: 10.1016/j.reprotox.2005.04.007 – volume: 340 start-page: 1234 year: 1999 ident: 10.1016/j.ajog.2012.11.014_bib2 article-title: Birth weight in relation to morbidity and mortality among newborn infants publication-title: N Engl J Med doi: 10.1056/NEJM199904223401603 – volume: 18 start-page: 564 year: 2001 ident: 10.1016/j.ajog.2012.11.014_bib32 article-title: Monitoring of fetuses with intrauterine growth restriction: a longitudinal study publication-title: Ultrasound Obstet Gynecol doi: 10.1046/j.0960-7692.2001.00590.x – volume: 37 start-page: 191 year: 2011 ident: 10.1016/j.ajog.2012.11.014_bib22 article-title: Longitudinal changes in uterine, umbilical and fetal cerebral doppler indices in late-onset small-for-gestational age fetuses publication-title: Ultrasound Obstet Gynecol doi: 10.1002/uog.7738 – volume: 61 start-page: 1261 year: 2008 ident: 10.1016/j.ajog.2012.11.014_bib23 article-title: The placenta in preterm birth publication-title: J Clin Pathol doi: 10.1136/jcp.2008.055244 – volume: 33 start-page: 44 year: 2009 ident: 10.1016/j.ajog.2012.11.014_bib24 article-title: Infant neurodevelopment following fetal growth restriction: Relationship with antepartum surveillance parameters publication-title: Ultrasound Obstet Gynecol doi: 10.1002/uog.6286 – volume: 182 start-page: 154 issue: 1 Pt 1 year: 2000 ident: 10.1016/j.ajog.2012.11.014_bib8 article-title: Umbilical artery doppler screening for detection of the small fetus in need of antepartum surveillance publication-title: Am J Obstet Gynecol doi: 10.1016/S0002-9378(00)70505-9 – volume: 40 start-page: 267 year: 2012 ident: 10.1016/j.ajog.2012.11.014_bib3 article-title: Neurodevelopmental delay in small babies at term publication-title: Ultrasound Obstet Gynecol doi: 10.1002/uog.11112 |
| SSID | ssj0002292 |
| Score | 2.4588864 |
| Snippet | The objective of the study was to evaluate perinatal and long-term complications of fetuses with intrauterine growth restriction (IUGR) compared with... Objective The objective of the study was to evaluate perinatal and long-term complications of fetuses with intrauterine growth restriction (IUGR) compared with... |
| SourceID | proquest pubmed crossref elsevier |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 130.e1 |
| SubjectTerms | Adolescent Adult Austria - epidemiology Cesarean Section - statistics & numerical data Child, Preschool Cohort Studies Developmental Disabilities - epidemiology Developmental Disabilities - etiology Doppler ultrasound Female Fetal Growth Retardation - epidemiology Follow-Up Studies Humans Infant, Newborn Infant, Small for Gestational Age - growth & development intrauterine growth restriction Magnetic Resonance Imaging - methods Nervous System Diseases - epidemiology Nervous System Diseases - etiology neurodevelopmental impairment Obstetrics and Gynecology Peripartum Period Pregnancy Pregnancy Outcome - epidemiology Retrospective Studies Risk Assessment small for gestational age Ultrasonography, Doppler Young Adult |
| Title | Perinatal complications and long-term neurodevelopmental outcome of infants with intrauterine growth restriction |
| URI | https://www.clinicalkey.com/#!/content/1-s2.0-S0002937812020698 https://www.clinicalkey.es/playcontent/1-s2.0-S0002937812020698 https://dx.doi.org/10.1016/j.ajog.2012.11.014 https://www.ncbi.nlm.nih.gov/pubmed/23159694 https://www.proquest.com/docview/1282518017 |
| Volume | 208 |
| WOSCitedRecordID | wos000314018700015&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVESC databaseName: Elsevier SD Freedom Collection Journals 2021 customDbUrl: eissn: 1097-6868 dateEnd: 20160731 omitProxy: false ssIdentifier: ssj0002292 issn: 0002-9378 databaseCode: AIEXJ dateStart: 19950101 isFulltext: true titleUrlDefault: https://www.sciencedirect.com providerName: Elsevier |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1bb9MwFLZ2QYgXxJ1ymYzE2-QqcS6OH8vUCRibJhiob5bj2lVLSaretP1yXjmOkzTt1nGReIkq107cns_2d07OBaG3EZNJKjUnKvUVCRX3SEppSmLeNzQBnqSKKP5vn9jZWdLr8fOdnZ9VLMxyzLIsubzkk_8qamgDYdvQ2b8Qd31TaIDPIHS4gtjh-keCP7cBfUVNkHV3cWshH-fZgNjN-LDIY9lfeQxZTrqYwwjtkkgYWUe-Da3911Z-sIR0AGo7tNmKHtOhqqVa5bGt3v80ElLkKQDJdnZTGFxlWq3Z8pcAwHfaundIZ-TpwN5P1qLUTgCtP8pyzi7xQcF5T2t35c_5_PsVOZYugsVlTNjoAjecFBkoQXlofFNaPGz1idp7ZLWLA61Kmrs49ZIGXGljT4ZTuq39xglfNMQ3nh_OlDFqy1E-sH5_tG1TvLow1_Vk3d2jE5_MaNsjX-x87HR8Ctw7dkW1N5J4-2JGhSeudd1F-5RFHLbj_c6Hbu9jTSIo5bTS3OyAMt7LuSZuzm4bp9qmMxXc6eIBul8qPbjjwPoQ7ejsEbp7Wrp1PEaTGrN4DbMYAINrzOLrmMUlZnFucIlZbDGLm5jFDrO4gdkn6Otx9-LoPSlLgRAVxnROwrQvNY1S7fvKxIwFPNaSSxNLGQTK62tPBZ7sK6lAvw9tGr405b5mhvnG00wGT9Felmf6OcKRkdSAEmM8z4TGRAmDO_MICEhoIunJFvKrP1OoMk--LdcyFpVD5EhYAQgrAFCgBQighQ7rMROXJebW3kElI1HFP8OJLQCEt45iN43Ss3JFz8Q2kLVQVI8sebXjy7994psKQAIOHfsmUWY6X8CTioh3ILeshZ45ZNW_GxTGiMc8fPHP832J7q2W_Su0N58u9Gt0Ry3nw9n0AO2yXnJQrpdfN2cLuQ |
| linkProvider | Elsevier |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Perinatal+complications+and+long-term+neurodevelopmental+outcome+of+infants+with+intrauterine+growth+restriction&rft.jtitle=American+journal+of+obstetrics+and+gynecology&rft.au=von+Beckerath%2C+Anne-Karen&rft.au=Kollmann%2C+Martina%2C+MD&rft.au=Rotky-Fast%2C+Christa%2C+MD&rft.au=Karpf%2C+Eva%2C+MD&rft.date=2013-02-01&rft.issn=0002-9378&rft.volume=208&rft.issue=2&rft.spage=130.e1&rft.epage=130.e6&rft_id=info:doi/10.1016%2Fj.ajog.2012.11.014&rft.externalDBID=ECK1-s2.0-S0002937812020698&rft.externalDocID=1_s2_0_S0002937812020698 |
| thumbnail_m | http://cvtisr.summon.serialssolutions.com/2.0.0/image/custom?url=https%3A%2F%2Fcdn.clinicalkey.com%2Fck-thumbnails%2F00029378%2FS0002937812X0005X%2Fcov150h.gif |