Unsuccessful trial accrual and human subjects protections: An empirical analysis of recently closed trials

Background Ethical evaluation of risk–benefit in clinical trials is premised on the achievability of resolving research questions motivating an investigation. Objective To determine the fraction and number of patients enrolled in trials that were at risk of not meaningfully addressing their primary...

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Veröffentlicht in:	Clinical trials (London, England) Jg. 12; H. 1; S. 77 - 83
Hauptverfasser:	Carlisle, Benjamin, Kimmelman, Jonathan, Ramsay, Tim, MacKinnon, Nathalie
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London, England SAGE Publications 01.02.2015 Sage Publications Ltd
Schlagworte:	Clinical trials Clinical Trials, Phase II as Topic - statistics & numerical data Clinical Trials, Phase III as Topic - statistics & numerical data Early Termination of Clinical Trials - statistics & numerical data Human Experimentation - statistics & numerical data Human subjects Humans Medical ethics Medical research Patient Selection Research Design - statistics & numerical data Risk Assessment United States United States trial accrual clinical trials research ethics recruitment Medical ethics
ISSN:	1740-7745, 1740-7753, 1740-7753
Online-Zugang:	Volltext
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