RB1 gene inactivation by chromothripsis in human retinoblastoma

Retinoblastoma is a rare childhood cancer of the developing retina. Most retinoblastomas initiate with biallelic inactivation of the RB1 gene through diverse mechanisms including point mutations, nucleotide insertions, deletions, loss of heterozygosity and promoter hypermethylation. Recently, a nove...

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Bibliographic Details

Published in:	Oncotarget Vol. 5; no. 2; p. 438
Main Authors:	McEvoy, Justina, Nagahawatte, Panduka, Finkelstein, David, Richards-Yutz, Jennifer, Valentine, Marcus, Ma, Jing, Mullighan, Charles, Song, Guangchun, Chen, Xiang, Wilson, Matthew, Brennan, Rachel, Pounds, Stanley, Becksfort, Jared, Huether, Robert, Lu, Charles, Fulton, Robert S, Fulton, Lucinda L, Hong, Xin, Dooling, David J, Ochoa, Kerri, Mardis, Elaine R, Wilson, Richard K, Easton, John, Zhang, Jinghui, Downing, James R, Ganguly, Arupa, Dyer, Michael A
Format:	Journal Article
Language:	English
Published:	United States 30.01.2014
Subjects:	Chromosome Aberrations Gene Expression Gene Expression Regulation, Neoplastic Gene Silencing Genes, Retinoblastoma Humans Oncogene Proteins - genetics Oncogene Proteins - metabolism Retinal Neoplasms - genetics Retinoblastoma - genetics Retinoblastoma - metabolism Retinoblastoma - pathology Retinoblastoma Protein - genetics Retinoblastoma Protein - metabolism
ISSN:	1949-2553, 1949-2553
Online Access:	Get more information
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