RB1 gene inactivation by chromothripsis in human retinoblastoma

Retinoblastoma is a rare childhood cancer of the developing retina. Most retinoblastomas initiate with biallelic inactivation of the RB1 gene through diverse mechanisms including point mutations, nucleotide insertions, deletions, loss of heterozygosity and promoter hypermethylation. Recently, a nove...

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Veröffentlicht in:	Oncotarget Jg. 5; H. 2; S. 438
Hauptverfasser:	McEvoy, Justina, Nagahawatte, Panduka, Finkelstein, David, Richards-Yutz, Jennifer, Valentine, Marcus, Ma, Jing, Mullighan, Charles, Song, Guangchun, Chen, Xiang, Wilson, Matthew, Brennan, Rachel, Pounds, Stanley, Becksfort, Jared, Huether, Robert, Lu, Charles, Fulton, Robert S, Fulton, Lucinda L, Hong, Xin, Dooling, David J, Ochoa, Kerri, Mardis, Elaine R, Wilson, Richard K, Easton, John, Zhang, Jinghui, Downing, James R, Ganguly, Arupa, Dyer, Michael A
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 30.01.2014
Schlagworte:	Chromosome Aberrations Gene Expression Gene Expression Regulation, Neoplastic Gene Silencing Genes, Retinoblastoma Humans Oncogene Proteins - genetics Oncogene Proteins - metabolism Retinal Neoplasms - genetics Retinoblastoma - genetics Retinoblastoma - metabolism Retinoblastoma - pathology Retinoblastoma Protein - genetics Retinoblastoma Protein - metabolism
ISSN:	1949-2553, 1949-2553
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